Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 2010 for “"Cancer cells"”.
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Jamming and Unjamming in Cancer Cells
Jamming' ist ein faszinierender, nicht vollständig verstandener Prozess in der Physik der weichen Materie. Zelluläres Jamming' tritt auch in biologischem Gewebe auf und muss sich im Fall von Krebszellen im Tumorgewebe aufgrund der dichten Packung der Zellen über der dichtesten Kugelpackung anders …
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Chemosensory Evaluation of Prostate Cancer Cells
Prostate cancer is the most commonly diagnosed disease and second most commonly caused death among men in America. Although much controversy surrounds the current methods of detection, PSA test and biopsy, no new methods have been approved as an effective method of detection. Biomarkers and …
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Interactions between cancer cells and inorganic materials
Cancer is a complex multi-faceted disease that poses a significant threat to world health. However, as our understanding of the disease improves so does the complexity of this threat. One aspect of complexity is tumour heterogeneity, subpopulations of which have been identified as being fundamental …
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Telomere Length Studies in Human Cancer Cells
… of repair. The telomeres of most normal diploid cells shorten with every cell division until they reach a critically short length, at which time the cells undergo senescence or apoptosis. Cancer cells which have the ability to divide indefinitely must prevent their telomeres from becoming …
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Steroid receptor crosstalk in breast cancer cells.
Breast cancer is the leading cause of cancer related death in women, and approximately 1 in 11 women will develop breast cancer before the age of 75. In 2003, breast cancer was responsible for 16% of cancer related deaths in Australian women. This demonstrates that throughout the life span of the …
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The chromatin landscape of colorectal cancer cells
… dynamics and transcriptional activity. With cancer increasingly becoming the greatest health epidemic of our time, the comprehensive genomic characterization of tumor genotypes has become central to current therapeutic approaches. Functioning as the basic unit of chromatin organisation, …
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Regulation of apoptosis in human cancer cells
Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis and to determine its validity across cancer cell types. In addition, we …
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Breast cancer cells cooperate during invasion and metastasis
… continues to be the leading cause of breast cancer-related deaths. Metastasis is a multistep process during which cancer cells leave the primary tumor, invade and seed inside secondary tissues, leading to lethal organ failure. Currently, no efficient method exists for the elimination of …
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Studies on cholesterol metabolism in prostate cancer cells
Prostate cancer (PCa) is the most common cancer in men in developed countries. Epidemiological studies have associated high blood-cholesterol levels with an increased risk of PCa, whilst cholesterol-lowering drugs (statins) reduce the risk of advanced PCa. Furthermore, PCa cells have been found to …
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Investigating senescence and senescence-escape in cancer cells
… role, the presence of senescent tumour cells and the ability of cancer cells to escape from senescence could potentially lead to therapy resistance and tumour recurrence. While a wide range of chemotherapeutic drugs are known to induce senescence in cancer, the effect of TIS in tumour …
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Microtubule Organisation in Normal and Colon Cancer Cells
… ApicoNbasal" polarisation" of" epithelial" cells" is" essential" for" normal" function," with" the" rearrangement" of" the"microtubule" cytoskeleton" on" differentiation" critical" for" the" establishment" of" polarity." "During" this" process,"microtubules" reorganise" to" …
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DNA G-quadruplex structures in human cancer cells
… present new opportunities for targeting in anti-cancer therapeutic interventions with small molecules. In this thesis, I expand the G4-profiling toolkit to better understand the biological roles of G4s, and potentially offer practical insights for G4-targeting drug development. First, …
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Role of DDX RNA helicases in cancer cells
Ester Cannizzaro ROLE OF DDX RNA HELICASES IN CANCER CELLS Abstract DEAD-BOX (DDX) RNA helicases are a large family of proteins characterized by the presence of a DEAD/H (Asp-Glu-Ala-Asp/His) motif. Their main function is to unwind double stranded RNA to promote downstream molecular events. They …
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Characterisation of RNA modifications in human cancer cells
… biological processes and human diseases, such as cancer. However, the vast majority of these modifications are uncharacterised, defined on limited substrates and are subject to enzymatic pathways. This shortfall is partly due to lack of reagents and technologies to study these modifications. In an …
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Natural product derivative activates autophagy in cancer cells
… antimalarial compounds, which have shown anticancer activity. In this study, we further characterized a novel artemisinin derivative namely EXP57EA which was previously designed and synthesized by the Chemistry Department at the University Of Cape Town. We determined the effect of EXP57EA on a …
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Detecting and molecular profiling cancer cells in patients
Although tumor cells obtained from human patients by surgical biopsy, image-guided intervention, blood draws or fluid drainage (paracentesis, thoracentesis) are a valuable source for analyzing tumor cells, conventional means of proteomic analysis are limited. Highly sensitive and quantitative …
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Antitumor activity of antimalarials in human breast cancer cells
… we showed that quinidine arrested MCF-7 cells in G1 phase of the cell cycle and led to a G1 to G0 transition followed by apoptotic cell death (Wang et al., 1998). The present experiments demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate …
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P53 mediated cell motility in H1299 lung cancer cells
… NFκB promote invasion and metastasis in tumor cells. Signals transduced by AKT and p53 are integrated via negative feedback between the two pathways. Tumor derived p53 was also indicated to induce NFκB gene expression. Due to the close relationship between p53/AKT and p53/NFκB, we hypothesized …
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Potentiating Antibody Therapy by Targeting Complement on Cancer Cells
… but mAb-induced antigen loss on tumor cells can lead to treatment failure. Loss of cell surface CD20 can occur in the treatment of lymphoid malignancies with anti-CD20 antibodies (mAbs) (eg rituximab, ofatumumab) through trogocytosis. This is a frustrated form of phagocytosis, where the …
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