Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Cancer cell biology"”.
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The role of mitochondrial complex II in cancer cell biology
Mitochondrie jsou pro většinu eukaryotických buněk nezbytné organely, které obsahují řadu komplikovaných, vzájemně interagujících proteinových struktur. Mezi ně patří mimo jiné i komplexy elektron transportního řetězce, tedy komplexy I - IV. Mitochondriální komplex II hraje klíčovou roli v buněčném …
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The effect of inhibiting KPNB1-mediated nuclear import on cancer cell biology and inflammatory transcription factor signalling
Cancer remains one of the major causes of morbidity and mortality globally. Many novel and innovative approaches have been employed to develop new chemotherapeutic strategies, of which targeted therapies aim to identify a molecular lesion or dysregulated pathway that cancer cells are dependent on. …
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Investigating the nuclear import protein KPn߀1 as a cancer therapeutic target
… with the development and progression of cancer, many of which are being investigated as potential therapeutic targets. Previous work in our laboratory and others reported the elevated expression of the nuclear import protein Karyopherin Beta 1 (Kpnβ1) in various cancers. The inhibition of …
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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
… subtypes of BRAF(V600) melanoma that inform new cancer cell biology and offer new therapeutic opportunities. Subtype membership defines sensitivity to clinical MEK inhibitors versus TBK1/IKBKE inhibitors. Importantly, subtype membership can be predicted using a robust quantitative 5-feature …
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Modulating ADAM-10 activity and expression in cervical and oesophageal cancer cells
… transmembrane and secreted proteins essential in cellular fate determination, wound healing, cell migration, proliferation and angiogenesis. Previous studies have linked a range of ADAMs, which include ADAM10 to cancer development and progression. Research in our laboratory found endogenous ADAM10 …
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Lamina-associated polypeptide 2 (LAP2) expression patterns in transformed and cancer cells
… nuclear assembly and disassembly during the cell cycle. Expression profiling studies, using microarrays, identified elevated levels of LAP2α in cervical cancer patient material compared to normal. Altered expression of LAP2 may thus have significance in the development of …
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Investigating the function of PINK1 in cancer development and pathogenesis
… kinase 1 (PINK1) was identified initially in cancer cells as a gene up‐regulated by overexpression of the central tumour suppressor, PTEN. Loss‐of‐function mutations in PINK1 were discovered subsequently to cause autosomal recessive Parkinsonʹs disease (ARPD). Despite much research focusing on …
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
Bladder cancer is the most common malignancy of the urinary tract. However, bladder cancer is a highly heterogenous disease and our understanding of the mechanisms that drive disease progression remain ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients …
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Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
… Aims: We proposed that circulating tumour cells (CTCs) are a viable source of tumour genetic material in which patient prognosis could be analysed. Firstly, we aimed to increase the sensitivity of an immunomagnetic enrichment protocol to capture CTCs. Secondly, we aimed to evaluate whole …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… shape, regulate enzyme activity, and underscore cellular metabolism. When redox poise fails and cells are overcome by oxidation, cellular death soon follows. Redox biology is an especially important aspect of cancer cell biology, because oncogene-induced hyperproliferation results in pro-oxidant …
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The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
… been linked to inhibition of metastasis in many cancers. However, in breast cancer, conflicting studies have shown that kisspeptin and KISS1R may play pro-metastatic or anti-metastatic roles. The aim of this study was to decipher the role of endogenous KISS1R in breast cancer cell proliferation, …
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Targeting anti-androgen resistance in prostate cancer using preclinical models with physiological nutrient levels
Prostate cancer is driven by upregulated androgen receptor signalling that regulates cellular growth and metabolism. While anti-androgen therapies such as Enzalutamide can be effective against prostate cancer, 60% of patients will develop Enzalutamide resistance which is currently incurable. Since …
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INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… transmembrane proteins belonging to a family of cell adhesion receptors evolutionary old and that play pivotal roles in physiological and pathological processes, such as neo-angiogenesis and cancer spreading. Integrins are composed by an extracellular domain, a single transmembrane region and a …
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Targeting Calpain-1 and Calpain-2 for Prevention of Breast Cancer Metastasis: In Vivo Insights and Drug Discovery Approaches
Due to breast cancer’s aggressive behavior and lack of effective targeted therapies once it becomes metastatic, it remains a leading cause of cancer mortality among women. Our lab is in a search for novel molecular targets that can be exploited to prevent breast cancer from metastasizing, which …
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The Role of Sphingosine Kinase 2 in Cell Growth and Apoptosis
… (SIP). Whereas, SphKl stimulates cell growth and survival, it was found that when overexpressed in mouse NIH 3T3 fibroblasts SphK2 enhances caspase-dependent apoptosis in response to serum deprivation, independently of S1P receptors. Sequence analysis revealed that SphK2 contains a …
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Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment
<p>Prostate cancer is the most commonly diagnosed malignancy in men in the United States and is projected to be the third most frequent cause of male cancer-related deaths in 2007 after lung and skin cancers. The initial treatment for prostate cancer at early stages is prostatectomy or radiation, …