Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Cancer biomarkers"”.
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Investigating nuclear transport proteins as secreted cancer biomarkers
… family as significantly upregulated in cervical cancer biopsies compared to normal cervical epithelial tissues. These results were validated at both mRNA and protein levels, and similar upregulation observed in oesophageal cancer. Recent mass spectrometry (MS) analysis of cancer cell secreted …
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Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
… pathological conditions including ovarian cancer, is selectively detected by the europium complex. LPA is also detected via a fluorescence increase in human plasma samples. The 2-sn-OH moiety of LPA plays a key role in promoting binding to the metal center. Other molecules found in common …
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Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
Liver cancer is one of the leading causes of deaths in many countries around the world therefore identifying new risk factors for liver cancer is a priority. The aim of this thesis was to investigate new risk factors for liver cancer and add new insights to previously identified liver cancer risk …
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Integrating High-throughput Technologies for the Identification and Validation of Novel Ovarian Cancer Biomarkers
Ovarian cancer is the most lethal gynaecological malignancy in North America. Although survival rates are high when the disease is diagnosed at an early stage, this decreases significantly in late-stage diagnoses. The majority of cases are of epithelial origin, which can be classified into four …
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Exploring the effect of peri-operative inflammation on systemic and local breast cancer biomarkers
… can occur in up to 25% of patients with breast cancer. Pre-clinical research has suggested that the surgical insult can promote the growth of new metastases and facilitate seeding of micrometastases into the circulation. The exact mechanism underlying the pro-metastatic potential of the …
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Mass Spectrometric Characterization of the MCF7 Cancer Cell Line: Proteome Profile and Cancer Biomarkers
The discovery of cancer biomarkers is crucial in the clinical setting to facilitate early diagnosis and treatment, thereby increasing survival rates. Proteomic technologies with mass spectrometry detection (MS) have the potential to affect the entire spectrum of cancer research by identifying these …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer is the second most diagnosed gynaecological malignancy and over all the fifth cause leading to death …
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Design, fabrication and testing of an acoustic resonator-based biosensor for the detection of cancer biomarkers
… is to develop this technology towards an early cancer detection capability. Specifically, I develop a solidly-mounted resonator with thin-film ZnO as my active piezoelectric layer. These resonators undergo an extensive development process to arrive at a final device design and are fully …
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Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
<p>"Despite continuous effort and progress in cancer detection and therapy, cancer remains one of our greatest health concerns because of its low survival rate and rapid incidence increase. One reason for this is the late detection and therefore pre-cancer diagnosis is crucial. In pre-cancer …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
… new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for molecular biomarker …
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Discovery and validation of novel blood biomarkers of breast and prostate cancer
Identification of novel biomarkers of breast and prostate cancers to supplement current diagnostic, prognostic and predictive tools is an important clinical need. Interaction between the host’s immune system and tumours is reflected in detectable changes in profiles of proteins in blood cells and …
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Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
Cancer is one of leading cause of deaths, and responsible for 8.2 million deaths worldwide. Especially, 70% of deaths from cancer occur in low or mid income countries. In order to deliver affordable and accessible cancer care to low income developing countries, it is critical to develop rapid, low …
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An optofluidic platform for longitudinal circulating tumor cell studies in mouse models of cancer
… process that is responsible for over 90% of cancer-related deaths. Circulating tumor cells (CTCs) that are shed from primary tumors represent the disseminating "seeds" that give rise to distant malignant growths. Despite their importance to metastasis, understanding of their role has been …
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Investigation of in-situ nanoimprinting of cell surface receptors: potential of a novel technique in biomarker research
Biomarkers are biological characteristics that can be observed or measured during disease conditions, and compared to the healthy state. Biomarkers have been used in medical history to study disease progression, to develop drugs, or to predict drug efficacy. However, in complex diseases such as in …
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Reservoir-based devices for the monitoring and treatment of disease
Cancer mortality still remains high despite significant investments in diagnostics, drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid …
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Design, Construction, and Screening of an shRNA Library Targeting Human Circular RNAs
… stability has prompted the study of circRNAs as cancer biomarkers. While expression studies are becoming widely used to profile circRNAs in multiple cancers, there are no genome-wide tools available to decrease their levels in cells. Methods that investigate the role of circRNAs through measuring …
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Liquid Chromatography – Mass Spectrometry for Protein Biomarker Discovery in Pancreatic Adenocarcinoma
Pancreatic cancer has one of the lowest survival rates of all cancers, partly due to the difficulty of detection in its early stages. Recent developments in liquid chromatography – mass spectrometry (LC-MS) technology have made it possible to profile proteins associated with disease in a …
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A novel genomic approach to multiple cancer diagnostics using mutations in blood bound EV RNA: Machine Learning Methods For Biomarker Detection and Protein Mutation Assessment
Identification of biomarkers is critical for early detection of cancers such as pancreatic ductal adenocarcinoma (PDAC), which is often diagnosed in later stages. Extracellular vesicles (EVs) released into the blood from tumour cells make good biomarkers for this purpose by protecting their …
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Investigation of biomarkers for noninvasive early diagnosis of cancer
<p>"Cancer is the second leading cause of death worldwide, and deaths from cancer worldwide are projected to continue rising, with an estimated 12 million deaths in 2030. Cancer occurs when cells in a part of the body begin to grow out of control. It develops very rapidly, and early diagnosis …
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Microfluidic cancer cell isolation system using magnetic nanoparticle hybrids and advanced interdigitated electrode technology
… systems. These technologies, through the popular biomarkers, i.e. DNA, RNA, proteins, antibodies, have already been implemented in clinical diagnosis and/or prognosis.An example of a successful commercial product is Invitrogen’s Dynabeads® Technology. Magnetic cell isolation technologies have been …
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