Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Cancer biomarker"”.
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Proteomics for cancer biomarker discovery
Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, understanding which genes are expressed in a tumor is not equivalent to …
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Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
Cancer is one of leading cause of deaths, and responsible for 8.2 million deaths worldwide. Especially, 70% of deaths from cancer occur in low or mid income countries. In order to deliver affordable and accessible cancer care to low income developing countries, it is critical to develop rapid, low …
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The Role of Proteomics in Colorectal Cancer Biomarker Discovery
Colorectal cancer is one of the most prevalent cancers within the UK and has a steadily rising incidence. If detected early Colorectal Cancer (CRC) is highly curable, but currently only 9% of patients present when the cancer is in the earliest stages (Dukes Stage A). The unique characteristics of …
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ORGANIC ELECTRONIC TRANSISTORS AND MICROFLUIDICS FOR CANCER BIOMARKER SENSING
MicroRNAs (miRNA) are a class of biomarkers whose relevance in oncology is increasing enormously, especially for cancers with high degree of invasiveness such as glioblastoma and lung cancer. Detection of miRNA circulating in blood appears a potential strategy for early diagnosis and patient …
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Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery
… groups (disease cases vs. healthy controls) for cancer biomarker discovery. However, differential expression analysis on independent studies for the same clinical types of patients often led to different sets of significant biomolecules and had only few in common. This may be attributed to the …
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The perioperative setting as a platform for breast cancer biomarker development
Breast cancer is the most common cancer in women, with 2.3 million new cases globally in 2022 (1). ‘Neoadjuvant’ systemic therapy prior to surgery is the standard of care for stage II-III human epidermal growth factor receptor-2 (HER2) positive breast cancer. The identification of predictive …
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Topic Model-based Mass Spectrometric Data Analysis in Cancer Biomarker Discovery Studies
… and cellular mechanisms may reveal useful biomarkers for human diseases including cancers. High-throughput omic technologies for identifying and quantifying multi-level biological molecules (e.g., proteins, glycans, and metabolites) have facilitated the advances in biological research in …
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Delivery of molecular-specific optical contrast agents for cancer biomarker detection in live cells and tissues
… non-invasive probes for the detection of cancer and its precursors. The topical use of optical contrast agents in vivo has been hindered, however, by the difficulty of delivering macromolecules through mucosal tissue. My goal was to develop a robust strategy for the delivery of …
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A study of functionalized iron oxide nanoparticles for selective recognition of kappa-casein: a breast cancer biomarker.
… a crucial role in the early detection of breast cancer. In this research, functionalized iron oxide (Fe3O4) nanoparticles were used for selective recognition of kappa casein (kcn) a breast cancer biomarker. The Fe3O4 was synthesized by the co-precipitation method. The particles were then coated …
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In vitro and in vivo imaging of peptide-encapsulated polymer nanoparticles for cancer biomarker activated drug delivery
Cancer creates one of the most significant public health problems not just in the United States, but worldwide. While one of the most effective treatment protocols for cancer is chemotherapy, the conventional agents used in chemotherapy affect normal tissue as well as cancerous tissue. This thesis …
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Integrin-Linked Kinase, ECM Composition, and Substrate Rigidity Regulate Focal Adhesion - Actin Coupling, Modulating Survival, Proliferation and Migration: Towards a Biophysical Cancer Biomarker
… that the proposed metric can also be used as a biomarker for specific disease states such as cancer.
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Development of nanoplasmonic devices for biosensing applications
… potential for early stage detection of cancer biomarkers in human serum samples for applications such as treatment monitoring and recurrence diagnosis due to their reliability for measuring protein-protein interactions. Plasmonic sensors are appealing for biosensing applications due to …
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Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
<p>"Despite continuous effort and progress in cancer detection and therapy, cancer remains one of our greatest health concerns because of its low survival rate and rapid incidence increase. One reason for this is the late detection and therefore pre-cancer diagnosis is crucial. In pre-cancer …
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Biosensor and assay development for the detection of disease biomarkers at the point of care
… particular, the detection of clinically relevant biomarkers for the screening, diagnosing, and monitoring of diseases such as cancer is an important goal in improving the treatment outcome and the quality of life of patients. In this thesis, an overview of biosensors and their applications is …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
Survival rates from pancreatic cancer have remained stagnant for decades due to the heterogenic nature of the disease. This dissertation aimed to find a new advanced biomarker and evaluate its clinical capabilities, thus enabling more individualised pancreatic cancer management. Between 2013 and …
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A spectroscopic smartphone biosensor for use in point-of-care diagnostic applications
… human interleukin-6, an important diagnostic cancer biomarker, and Ara h 1, one of the principle peanut proteins responsible for allergic reactions. PC-based sensing was completed with a Protein A-immunoglobulin G interaction with a .009 nm accuracy. All of these demonstrations were completed …
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Bioinformatics analysis of epigenetic variants associated with melanoma
The field of cancer genomics is currently being enhanced by the power of Epigenome-wide association studies (EWAS). Over the last couple of years comprehensive sequence data sets have been generated, allowing analysis of genome-wide activity in cohorts of different individuals to be increasingly …
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Reservoir-based devices for the monitoring and treatment of disease
Cancer mortality still remains high despite significant investments in diagnostics, drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid …
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Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
<p>Current standard cancer treatments such as chemotherapeutics, and radiation therapy are nearly as likely to kill the patient as cure the cancer. Therapies that have such a narrow window of efficacy are necessary for the treatment of aggressive diseases, but safer alternatives must be created. By …
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New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
… For this reason, Tn determinant is a convenient cancer biomarker. Mucin-like glycopeptides and glycoproteins, in particular MUC1, incorporate this structure in their sequence. While in normal cells this O-glycosylated protein carries complex oligosaccharides, in cancer cells, MUC1 expression is …
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