Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Cancer associated fibroblasts (CAFs)"”.
-
Regulation and inhibition of pro-tumorigenic microenvironments
… number one risk factor for the development of cancer. While accumulation of epithelial cell mutations is a driving factor for this risk, the role that the tumor microenvironment plays in this process is now well established. Indeed, seminal work has shown that tumorigenic cells unable to grow …
-
Fibroblast Heterogeneity In Pancreatic Cancer Immunity
<p>Fibroblasts are a unique cell type defined by their mesenchymal phenotype and exclusion from epithelial, immune, and endothelial cell subsets. Although well studied in wound healing, cancer associated fibroblasts (CAFs) are incredibly heterogeneous, leading to contradictions as to the roles CAFs …
-
The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
<p>Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer death among women in the United States. The high lethality of EOCs stems from rapid peritoneal involvement. EOCs frequently colonize peritoneal surfaces that overlie connective and adipose tissues. However, the mechanisms that …
-
Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… (PDAC) remains one of the deadliest cancers, with limited treatment options and poor survival rates. It is characterised by strong driver mutations, extensive epigenetic reprogramming, and a dense tumour microenvironment (TME). A defining feature of the PDAC TME is its fibrotic …
-
Dissecting the impact of SMAD4 loss and KRAS mutations in pancreatic ductal adenocarcinoma
… to make this disease the second leading cause of cancer-related deaths by 2040. Poor survival rates for PDAC are a consequence of late-stage diagnosis due to non-specific early-stage symptoms, and largely ineffective treatment options. Treatments are ineffectual particularly for advanced disease …
-
Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma
… patrolling tissues to detect and destroy cancerous cells by directing cytotoxic granules toward the immunological synapse formed with their target. Although CTL infiltration into solid tumours often correlates with improved patient outcomes, the mechanisms by which CTLs are recruited …
-
Determining stromal evolution in response to immune checkpoint inhibition
… (TME) to ICI therapy, focusing on cancer-associated fibroblasts (CAFs). CAFs are an abundant and heterogeneous component of the TME, supporting tumourigenesis by secreting growth factors, cytokines, chemokines, extracellular matrix (ECM) and remodelling the physical environment. …
-
ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS
High-grade serous ovarian cancer (HGSOC) is a highly heterogeneous and aggressive malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor …
-
RESOLVING TUMOR HETEROGENEITY THROUGH HIGH RESOLUTION MULTI-MODAL TRANSCRIPTOMICS: INTEGRATIVE SINGLE-CELL ATLASES AND GENERATIVE SPATIAL MODELING
… case studies namely high-grade serous ovarian cancer (HGSC) and glioblastoma multiforme (GBM). The first part of the thesis focuses on building and leveraging a harmonized single-cell transcriptomic atlas (OvCA) constructed from patient-derived samples across multiple tissue sites and treatment …
-
The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… Alpha-smooth muscle actin+ (αSMA+) cancer-associated fibroblasts (CAFs) are the most abundant stromal component, as well as mediators of stromal deposition. The hypoxia-inducible factors (HIF1 and HIF2) coordinate responses to hypoxia, yet, despite their known association to poor …
-
Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses
… immune checkpoint therapy (ICT) has transformed cancer treatment, but its effectiveness is limited in certain cancers like pancreatic ductal adenocarcinoma (PDAC), which exhibit resistance to this therapy. To overcome this challenge, it is crucial to understand the underlying mechanisms that …
-
Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
1 in 9 men will be diagnosed with prostate cancer during their lifetime and it remains the second leading cause of cancer death among American men. Men who fail standard-of-care androgen deprivation therapy (ADT) and progress to metastatic castration resistant prostate cancer (mCRPC) are left with …
-
Tumor-Cell Derived Inhibin, Beta A Is Essential For Adrenergic Effects On Fibroblast Activation
… of adrenergic signaling on other cells such as cancer-associated fibroblasts (CAFs) within the tumor microenvironment is limited. We hypothesize that adrenergic signaling and norepinephrine can accelerate the induction of CAF-phenotype to promote inflammation and metastasis.</p> …
-
Defining the pro-tumour impact of the evolving stromal microenvironment
… role within the microenvironment. In particular, cancer associated fibroblasts (CAFs) represent a diverse population of cells, which cannot be identified by one universal marker. CAFs promote tumour growth and dissemination by secreting growth factors, stimulating angiogenesis, aiding the …
-
Characterising the crosstalk between pancreatic fibroblasts and group 2 innate lymphoid cells in pancreatic homeostasis, inflammation, and neoplasia
… our incomplete understanding of their role in cancer. Another emerging notion within the field is that ILC2 interactions with cells of mesenchymal origin, including fibroblasts, are critical for their functions in homeostasis and inflammatory states. Furthermore, immune niches enriched in …
-
Development of a hydrogel-based microfluidic model of the lymph node
… to mount antigen specific immune responses. In cancers, the tumour-draining lymph node (TDLN) is the site of initial anti-tumour immune response. The TDLN undergoes dramatic reprogramming in response to tumour drainage that is still partly unclear. In vivo models do not easily permit us to …
-
Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
… phenotypes such as Triple- Negative Breast cancer (TNBC). To do define the microenvironmental alterations that occur during cancer, we first established a human breast cell atlas, a reference of normal breast cell types from disease free women. We profiled 535,941 cells from 62 women and …
-
The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
Breast cancer is the most common cancer diagnosed in women in the United States. The basal-like breast cancer subtype represents about 12% of breast cancer and has the worst outcome in patients due to lack of effective therapies. Tumor stroma plays an important role in cancer progression. Cancer …
-
Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
Lung cancer is expected to kill ~150,000 people this year, encompassing 25% of all cancer related deaths making lung cancer the leading cause of cancer-related mortality in men and women. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which …
-
Development of Microfluidic 3D Cell Array with Tumor-Stroma interaction for Cancer Immunotherapy Drug Screening
<p>In the United States, breast cancer is the first-leading cancer type in women. Current strategies to treat breast cancer mainly rely on surgery and chemotherapy, particularly for those cancer subtypes lacking specific antigens, such as triple-negative breast cancer (TNBC). However, the low …
Page 1 of 2