Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Cancer associated fibroblast"”.
-
Cancer Associated Fibroblast Derived Angiogenic Factor Mfap5 In Ovarian Cancer Progression
<p>Advanced stage ovarian cancer is the most lethal gynecologic malignancy. No major improvement on patient survival has been achieved in the past decade. Therefore, identification of predictive or prognostic markers and further understanding of the molecular mechanisms in ovarian cancer …
-
The Biomechanical Role of Cancer-Associated Fibroblasts In Tumor-Stroma Reciprocity
… to tumorigenesis will also be discussed. The cancer-associated fibroblast and the tumor-associated macrophage intimately influence the homeostasis between the tumor and extracellular matrix and can affect the survival and proliferation of tumor cells. This review will address how mechanical …
-
ELUCIDATING THE FUNCTIONS OF TAp73 IN BREAST CANCER
… isoform was highly expressed in human breast cancer as compared to the normal tissue. Therefore, this project aims to elucidate TAp73 functions in breast cancer development. Using three cell type-specific TAp73 knockout MMTV-PyMT mouse breast carcinoma mouse model, our results suggested that …
-
Investigating the role of PKC-β in tumour activated stromal cells
… the role of PKC-β in stromal cells of other cancers remains largely uncharacterised. Here I demonstrate novel mechanistic insights into BMSC- mediated drug resistance in CLL. Stromal PKC-β activation regulates levels of active transforming growth factor beta 1 (TGF-β1) and gene expression of …
-
Dissecting the impact of SMAD4 loss and KRAS mutations in pancreatic ductal adenocarcinoma
… to make this disease the second leading cause of cancer-related deaths by 2040. Poor survival rates for PDAC are a consequence of late-stage diagnosis due to non-specific early-stage symptoms, and largely ineffective treatment options. Treatments are ineffectual particularly for advanced disease …
-
Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
… remains one of the most difficult to treat major cancers, with a 5-year survival of less than 5%, and little to no improvement in prognosis over the previous fifty years. The complexity and heterogeneity of the pancreatic tumour and its highly desmoplastic stromal microenvironment present major …
-
The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration
… pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that Akt …
-
The Role of Autotaxin in Cancer
… and inflammatory diseases and to several cancers. ATX is a therapeutic target and the ATX inhibitor IOA-289 is currently in Phase 1B clinical trials for the treatment of patients with metastatic pancreatic cancer, in combination with gemcitabine. ENPP2 is overexpressed in both pancreatic …
-
The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
<p>Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer death among women in the United States. The high lethality of EOCs stems from rapid peritoneal involvement. EOCs frequently colonize peritoneal surfaces that overlie connective and adipose tissues. However, the mechanisms that …
-
Oncogene-induced reprogramming of heterotypic cellular interactions
… frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., colorectal, pancreatic, and lung cancer). KRAS mutations not only perturb intracellular signalling networks in cancer cells but increasingly are recognised for their role in modifying the …
-
MicroRNAs and Extracellular Vesicles: investigating their role in the Testicular Germ Cell Tumour Microenvironment.
… molecules between the tumour and the TME in many cancer types. Here, TGCT-overexpressed miRNAs were found to be highly abundant in EVs derived from TGCT cells. Moreover, TGCT-derived EVs were efficiently internalised by TME cells, including fibroblasts, macrophages and endothelial cells. EV-uptake …
-
Determining stromal evolution in response to immune checkpoint inhibition
… (TME) to ICI therapy, focusing on cancer-associated fibroblasts (CAFs). CAFs are an abundant and heterogeneous component of the TME, supporting tumourigenesis by secreting growth factors, cytokines, chemokines, extracellular matrix (ECM) and remodelling the physical environment. …
-
Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
<p>Colorectal cancer Colorectal Cancer (CRC) is the leading cause of cancer-related deaths, with the majority of these deaths occurring after metastases. In this study, we used single-cell RNA transcriptome sequencing to characterize the cellular and molecular features of primary CRC and colorectal …
-
The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
Breast cancer is the most common cancer diagnosed in women in the United States. The basal-like breast cancer subtype represents about 12% of breast cancer and has the worst outcome in patients due to lack of effective therapies. Tumor stroma plays an important role in cancer progression. Cancer …
-
Development of Microfluidic 3D Cell Array with Tumor-Stroma interaction for Cancer Immunotherapy Drug Screening
<p>In the United States, breast cancer is the first-leading cancer type in women. Current strategies to treat breast cancer mainly rely on surgery and chemotherapy, particularly for those cancer subtypes lacking specific antigens, such as triple-negative breast cancer (TNBC). However, the low …
-
Single cell and spatial analysis characterize metabolic DPEP1+ fibroblasts in PDAC
… of novel therapeutic approaches. Understanding cancer-associated fibroblasts (CAF) metabolism reprogramming in PDAC tumor microenvironment (TME) may uncover novel therapeutic targets. Here, we used single cell and spatial transcriptomics to comprehensively characterize the TME content of human …