Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Cancer Treatments"”.
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Exploring Cervical Cancer Treatments, Coping And Sexual Self-Concept After Cervical Cancer
<p>ABSTRACT</p> <p>EXPLORING CERVICAL CANCER TREATMENTS, COPING ADAPTATION AND WOMEN'S SEXUAL SELF-CONCEPT AFTER CERVICAL CANCER</p> <p>By</p> <p>BARBARA G. HOLLIE</p> <p>Cervical cancer survivorship is increasing as a result of improved biomedical science and health care. Due to the nature of …
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Exploring the complex relationships between pre-existing conditions (comorbidities) and cancer treatments and outcomes
… pre-existing conditions (comorbidities) and cancer treatments and outcomes, including survival, mortality, quality of life, resource use and costs. Methods: Systematic reviews synthesised evidence from high-income countries for associations between comorbidity and differences in gastric, …
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Intracellular Transport in Cancer Treatments: Carbon Nanohorns Conjugated to Quantum Dots and Chemotherapeutic Agents
Cancer therapies are often limited by bulk and cellular barriers to transport. Nanoparticle or chemotherapeutic compound intracellular transport has implications in understanding therapeutic effect and toxicity. The scope of this thesis was to study the intracellular transport of carbon nanohorns …
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Optimising the care of patients receiving oral systemic anti-cancer treatments: a mixed methods study
Background: The use of oral systemic anti-cancer treatment (SACT) has increased significantly in recent decades. Patient experience of receiving these treatments is relatively unknown and under-reported. In response to national recommendations and the National Patient Safety alert (2008) regarding …
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Incorporating Magnetic Nanoparticle Aggregation Effects into Heat Generation and Temperature Profiles for Magnetic Hyperthermia Cancer Treatments
In treating cancer, a primary consideration is the target specificity of the treatment. This is a measure of the treatment dose that the cancerous (target) tissue receives compared to the dose that healthy tissue receives. Nanoparticle (NP) based treatments offer many advantages for target …
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Urinary Volatile Organic Compounds for Detection of Breast Cancer and Monitoring Chemical and Mechanical Cancer Treatments in Mice
… to identify metabolic transformations in breast cancer through urinary volatile organic compounds in mammary pad or bone tumor mice models. Subsequently, it focuses on investigating the efficacy of therapeutic intervention through identified potential biomarkers. Methods for monitoring tumor …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
Small Cell Lung Cancer (SCLC) cells activate a signal pathway in response to chemotherapy, as a result the cancer rapidly develops chemoresistance. Since the late 1980’s SCLC has a poor prognosis with a 5 year survival rate of only 5%, highlighting the need for novel therapeutic intervention. This …
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A mixed methods study exploring fatigue in advanced cancer care
… Many people are living for longer with advanced cancer because of improvements in cancer treatments. Fatigue is the most prevalent and burdensome symptom in this cohort of patients. Thus, many could benefit from any improvements in the assessment and management of fatigue in advanced cancer care. …
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
Cancer treatments often target singular oncoproteins in attempt to block one hallmark of cancer and stop tumor growth and progression. However, although these treatments are often initially effective, many cancer patients develop resistance and experience relapse due to redundant signaling or tumor …
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T-cell-directed bioorthogonal catalysis for localised prodrug activation in cancer therapy
Cancer is one of the most severe diseases worldwide, accounting for almost 10 million deaths a year. While modern cancer treatments have improved patient outcomes in many cancer types, solid cancers, metastases and relapse still pose immense challenges. Cancer treatments remain limited by poor …
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Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers
… are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer …
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Monitoring apoptosis in intact cells by high-resolution magic angle spinning 1H NMR spectroscopy
… apoptosis is a well-known strategy in developing cancer treatments, therefore non-invasive monitoring of apoptosis in intact cells could contribute towards the characterisation of drug efficacy and hence drug discovery. A known metabolic marker of apoptosis is a notable increase in proton NMR …
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
… may not detect early therapy responses, as many cancer treatments initially manifest at a microscopic level before any significant change in size becomes evident. Quantitative imaging techniques can identify these early effects, providing a valuable window of opportunity to effectively manage …
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Advancing and expanding siRNA and saRNA therapeutics applications through chemical modifications
… RNA that are used to treat complex diseases like cancer and rare genetic diseases. They rely on biological pathways in our body to work. Two pathways that are important to this study are gene silencing and activation. Short interfering RNAs (siRNAs) silence genes, while short activating RNAs …
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Oncology Nurses' Attitudes toward Cancer Clinical Trials and Their Perceptions of Patients' Understanding
Clinical trials in oncology that evaluate new cancer treatments are essential. However, in the United States only 2%-4% of eligible adult cancer patients participate in the National Cancer Institute's clinical trials annually. Oncology nurses have a major role in the care of patients contemplating …
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Psychoeducational Program for Breast Cancer Patients: A Pilot Study
Cancer treatments adversely affect cognition in general and memory in particular. The current study focused on developing and investigating the feasibility and effectiveness of a group program for breast cancer survivors suffering from cognitive problems post cancer treatment. This intervention was …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
… of receptors is dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore, a detailed understanding of the mechanisms of receptors activation is critical. However, despite a plethora of biochemical …
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A Study of Machine Learning Approaches for Integrated Biomedical Data Analysis
… recommendation system which recommend cancer treatments to patients. Compared to the traditional way of using only users' rating to impute missing values, we proposed a method to incorporate users' profile to help enhance the accuracy of the prediction.
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OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… of CRISPR-Cas9 technology has revolutionized cancer research by enabling targeted genome modifications in tumour cells, offering insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of …
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