Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Cancer Transformation"”.
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Mitochondrial metabolism in cancer transformation and progression
Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical relevance are unclear. In this study, I systematically …
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Tumor Suppression by a TRNA Synthetase
… substantial progress in treatment, breast cancer remains a leading cause of cancer mortality among women. During malignant transformation, healthy mammary cells must bypass tumor suppressive checkpoints and activate pro-growth pathways. Enhanced protein translation is one such hallmark of …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
… gradually transition along the path of oncogenic transformation3,4. While transgenic mouse studies have established the causative role of primary oncogenic TFs in driving leukemia, the mechanisms through which these proteins contribute to disease progression remain unclear. One subtype of T-ALL, …