Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 409 for “"Cancer Therapy"”.
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Multifunctional Nanoparticles for Cancer Therapy
The relapse of cancer after first line therapy with anticancer agents is a common occurrence. This recurrence is generally accepted to be due to the presence of a small subpopulation of cells called cancer stem cells. Thus, it is essential to use a combination therapy consisting of at least one …
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Carbon Nanotubes in Cancer Therapy
… living systems specifically for applications in cancer therapy. Two main types of CNTs; single-walled (SWNT) and multi-walled (MWNT) have been investigated. Pristine CNTs are poorly soluble in aqueous solvents, and therefore need to be functionalized (f-CNT) to enhance their solubility and …
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Antibody engineering for cancer therapy
… have been developed successfully to treat cancer. In this Thesis, novel antibodies and antibody-conjugate against two tumor antigens, AF-20 antigen and human aspartyl (asparaginyl) [beta]- hydroxylase (HAAH), were developed. Previously, these two tumor antigens have been shown to be present …
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Protein engineering for cancer therapy
… interfere with anti-tumor immune responses in cancer patients. In the first part of this work, we present a novel class of engineered Interleukin-2 (IL-2) analogues that antagonize the IL-2 receptor, for inhibiting Treg suppression. These antagonists are engineered for high affinity to the IL-2 …
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Examining metabolic vulnerabilities for cancer therapy
Metabolic reprogramming is essential for cancer cells to balance energetics, maintain redox homeostasis, and synthesize biosynthetic precursors. Many chemotherapeutics that target metabolism are essential components of standard cancer treatment regimens, arguing that there is a therapeutic window …
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
A rising trend in lung cancer chemotherapy involves the development of agents that exploit molecular targets overexpressed in tumors, with hopes of increasing specificity, and in turn, efficacy. β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by …
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Targeting Ph Domain Proteins For Cancer Therapy
<p>Targeted therapy has been one of the most promising treatment options for cancer during the past decade. Discoveries of potent and selective small molecule inhibitors are critical to new and promising targeted therapy. Pleckstrin Homology (PH) domain proteins are one of the biggest protein …
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The Incorporation of Nanomaterials in Cancer Therapy
<p>Cancer is one of the main killers of mankind. There are more than one million people in the U.S. alone are diagnosed with cancer each year. There have been millions of dollars invested into finding a cure. Equally important is the pursuit of new ways to treat cancer. Current treatment methods …
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Redox Flow Iontophoresis for Brain Cancer Therapy
A fundamental limitation for the success of chemotherapy in brain cancer treatment is the blood brain barrier. It plays a pivotal role in protecting the central nervous system, but also significantly hinders the dose of cancer drugs which can be delivered into a tumour. One option for circumventing …
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Carbon Monoxide Prodrugs for Targeted Cancer Therapy
… clinical conditions, including inflammation and cancer. However, challenges in targeted and controlled delivery have limited its clinical application, prompting the development of novel CO-releasing prodrugs. This thesis presents the design and development of radical-activated, metal-free …
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New precious metal compounds in cancer therapy
Cisplatin is one of the most effective cancer medications currently available. However, it is seriously limited by patient toxicity and drug resistance. As such, there is a real need for altemative treatments. Some compounds of gold(l) have been found to be biologically active in various contexts, …
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Generalized Inverse Optimization with Application to Cancer Therapy
… We apply the proposed methodologies to prostate cancer therapy data and provide novel insights for radiation therapy treatment planning. In the first part of the thesis, we briefly review recent theoretical development of inverse optimization and discuss how this thesis contributes to the …
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Paclitaxel nanoparticles for breast cancer therapy in pregnancy
Breast cancer can complicate pregnancy and result in fetal and maternal morbidity and mortality. These effects are often compounded by restrictions in the diagnosis and treatment of breast cancer due to implications on fetal health. A number of new paclitaxel nanoformulations for the treatment of …
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Development of Multifunctional Nanoparticles for Cancer Therapy Applications
… been developed to address continued issues in cancer therapy, including cancer diagnosis and efficient drug delivery.</p><p> CNT surfaces were modified by plasma polymerization, providing functional groups for conjugation. Luminescent amine labeled quantum dots were fixed to the surface of the …
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Investigation of orally administrable bacteria for cancer therapy
… prognoses and treatment outcomes of several cancers, using conventional drugs, is being countered by investigations into a range of new, advanced formulations, of which bacteria-based anticancer therapies are one. Bacteria-based treatments hold an especially intriguing place within this group …
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Engineering M13 bacteriophage platforms for cancer therapy applications
… manipulated to serve as tethers to carry various therapy and imaging agents and target specific cancer sites. Now with the ability to control the aspect ratio of these rigid, rod-like phages we can further improve on M13 based cancer detection by optimizing for phage blood circulation and tumor …
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Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy
… treatments. In comparison to conventional chemotherapy, polymeric delivery systems are implantable at a local targeted site and biodegradable after a sufficient therapeutic span. The objectives of this project were to fabricate and characterize an implantable polymeric vehicle for a local …
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