Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 113 for “"Cancer Therapeutics"”.
-
Development of exosome-based anti-cancer therapeutics
… (HCC) exosomes are found to be responsible for cancer progression, metastasis, and angiogenesis via cellular communications. However, studying cancer derived exosomes in vitro is limited, due to the way cell lines are grown in medium supplemented with foetal bovine serum (FBS) that contains …
-
IDENTIFYING AND EXPLOITING SYNTHETIC LETHALITY FOR CANCER THERAPEUTICS
… us to gain deeper insights into their role in cancer and therapy development. In this thesis, new methods have been developed to discover SL pairs and to utilize SL pairs in biological network mining and clinical decision support. Two new methods are designed to identify potential SL pairs …
-
Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
-
Bst2 Isoforms: Distribution and Potential Use In Cancer Therapeutics
<p>Identifying a cancer-specific cellular target is one of the key factors that can pave a “bench to the bedside” path of a target therapy. Bone marrow stromal cell antigen 2 (BST2) is a raft-associated type II transmembrane protein with an unusual topology. Analyses showed a variable degree of …
-
Novel Cancer Therapeutics, the Generation of ROS, and Cell Survival
The impact of Ad.mda-7 on the survival of renal cell carcinoma lines (RCC), primary renal epithelial cells, glioblastoma multiforme lines (GBM), and primary rodent astrocytes is unknown. The present studies examine whether the GST fusion protein, GST-MDA-7, and the adenovirus, Ad.mda-7, altered the …
-
Photoactivatable Organic and Inorganic Nanoparticles in Cancer Therapeutics and Biosensing
… and dyes have been used in PDT to treat various cancers, skin diseases, aging and sun-damaged skin. These second generation sensitizers have yielded reduced skin sensitivity and improved extinction coefficients (up to ~ 105 L mol-1 cm-1). While PDT based on small molecule photosensitizers has …
-
Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics
… lack of durable clinical responses or, in many cancer types, lack of even initial responses. While great headway has been made on characterizing mechanisms of resistance, understanding the full influence of complex intercellular interactions on drug resistance remains a challenge. Here, we …
-
Integrating Cell-level Kinetic Modeling into the Optimization of Cancer Therapeutics
Cancer therapy benefits today from the availability of new promising classes of drugs such as therapeutic proteins. Due to their ability to specifically bind targets in the body they allow to modulate specific chemical reactions and ultimately to modify the functional response of the cell, such as …
-
Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics
… and development of novel small molecules as anti-cancer agents plays an integral role in the fight against cancer. Such efforts will lead to the development of the therapies of tomorrow. Potentially useful molecules may be discovered through cell-based toxicity screens, enzyme-based in vitro …
-
Synthetic strategies to improve the cytotoxicity of platinum-based cancer therapeutics
… tethering of amines that can be used to target cancer cells. The first chapter is a brief introduction on the scope of platinum compounds that have been made. It also provides general background on the proposed mode of action. The second chapter adapts the knowledge of making cisplatin derived …
-
Development and application of novel analytical methods for molecularly targeted cancer therapeutics
… clinical development and routine use of anti-cancer drugs. In furtherance of this important aim, the research in this thesis sought to develop and apply novel, highly sensitive, analytical methods to examine and understand correlations of drug levels with drug resistance mechanisms, …
-
Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
For the treatment of cancer, peptides hold great potential as both targeting and therapeutic agents. One particularly promising anti-cancer strategy is peptides derived from the third Bcl-2 homology domain (BH3), which antagonize pro-survival Bcl-2 proteins and induce apoptosis. Unfortunately, …
-
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
Prostate cancer is the most common male malignancy and remains the second-leading cause of death due to cancer in American men. While surgery and radiation are effective in prostate cancer therapy at early stages, the majority of the patients ultimately relapse and develop advanced prostate cancer. …
-
SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS
Targeted therapies are crucial for personalizing cancer treatment, but tumour heterogeneity presents a challenge in the identification of effective targets. Polo-like kinase 1 is overexpressed near ubiquitously across cancer types and dysregulation of polo-like kinase 1 is closely tied to …
-
De novo Design of Mini-Protein Binders Targeting Allosteric Sites of MALT1 Towards Cancer Therapeutics
Η MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1) αποτελεί βασικό ρυθμιστή της σηματοδότησης NF-κB, και η απορρύθμιση της δραστηριότητάς της εμπλέκεται σε ποικίλες αιματολογικές κακοήθειες και συμπαγείς όγκους, συμπεριλαμβανομένων του γλοιοβλαστώματος και του παγκρεατικού …
-
Translational development and mechanistic insights into 3-(4- hydroxyphenyl)indoline-2-ones as a potent class of breast cancer therapeutics
Cancer research and therapy have seen major developments in recent decades with the paradigm of surgery/radiotherapy/chemotherapy advancing towards selective small molecules, biologics, immunotherapy, and other targeted therapies. Small molecule drug development remains an important cornerstone of …
-
Synthesis and pharmacological evaluation of novel anti-tumour prodrugs. Synthesis and pharmacological investigations into novel MMP-activated peptide-based prodrugs of methotrexate as potential cancer therapeutics
Methotrexate (MTX) is an antimetabolite anticancer agent that is used in treatment of multiple cancers, such as acute lymphoblastic leukaemia and osteosarcoma. A lack of selective tumour toxicity is one of the major problems associated with MTX chemotherapy, especially when given at high doses, as …
-
Development of novel heterocyclic compounds as vascular targeting agents
In chapter one the biology of cancer is introduced along with a brief history of drug treatment and the status quo of cancer therapeutics. This includes a general overview of cancer prevalence, carcinogenesis, and biochemistry. The main targets for cancer therapeutics are introduced along with …
-
Antibody engineering for tumor immunotherapy
Antibodies have been used as cancer therapeutics for several decades. One area in which this therapy may be improved is the retention time of antibody in the tumor relative to normal tissue. In this Thesis, we have attempted to elucidate the mechanisms that are most influential to improving …
-
Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts
… benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N'-bis(naphthylmethyl)imidazolium bromide salts …
Page 1 of 6