Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Cancer Subtype"”.
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Disparities in breast cancer subtype, staging, and access to mammography services in the Lower Mississippi Delta Region
… as a whole. It also has far higher breast cancer mortality rates than the nation. Black women in the Region have higher breast cancer mortality rates than white women in the Delta Region and have higher breast cancer mortality rates than black women in other parts of the country. More …
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The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
Breast cancer is an extremely heterogeneous disease comprising at least ten different subtypes, each exhibiting different characteristics in progression, prognosis and response to treatment. Transforming growth factor β (TGFβ) a member of the TGF superfamily of cytokines differentially regulates …
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NCIS: a network-assisted co-clustering algorithm to discover cancer subtypes based on gene expression
Cancer subtype information is critically important for designing more effective treatments. In this thesis, we introduce a new co-clustering algorithm for cancer subtype identification, which combines the information of gene networks to simultaneously group samples and genes into biologically …
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Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a …
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Evaluating Phosphatidylinositide as Lipid Biomarkers for Hyperglycemia-related Triple-negative Breast Cancer Aggressiveness
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, marked by limited treatment options and poor patient outcomes. Clinical and epidemiological studies suggest that systemic metabolic conditions, particularly high blood glucose associated with Type 2 Diabetes, may …
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CancerSubtyper: A Web-Based Deep Learning Platform for Cancer Subtyping Through DNA Methylation Data
Cancer subtyping plays a critical role in understanding tumor heterogeneity, predicting patient outcomes, and guiding personalized therapies. While DNA methylation data offers an informative molecular source for subtyping, leveraging its signals across cohorts remains challenging due to high …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
<p>Triple-negative breast cancer (TNBC) is a highly metastatic breast cancer subtype. The epithelial-to-mesenchymal transition (EMT) of cancer cells is a key feature of the metastatic cascade and is not a binary process but often generates malignant cells with both epithelial (E) and mesenchymal …
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Identifying and Minimizing Underspecification in Breast Cancer Subtyping
… and minimize underspecification of deep learning cancer subtype predictors. To address these goals, this work details the development of Predicting Underspecification Monitoring Pipeline (PUMP), a software tool to provide methodology for data analysis, stress testing, and model evaluation. In this …
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
<p>Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and is difficult to treat. A diagnosis of TNBC means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone, and HER2– are not present in the …
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SIK2 Inhibitor GRN-300 Enhances Sensitivity to Paclitaxel Treatment in Triple-Negative Breast Cancer
<p>Breast cancer is one of the most frequently diagnosed cancers worldwide, with approximately 15% classified as Triple-Negative Breast Cancer (TNBC). TNBC lacks expression of estrogen (ER) and progesterone (PR), and does not overexpress HER-2, leaving patients without effective targeted therapies. …
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Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
… half of all hereditary breast and ovarian cancers, and the gene is silenced via promoter methylation and loss of heterozygosity in a proportion of sporadic breast and ovarian cancers. The objective of this study was to determine whether GRN163L, a telomerase inhibitor, currently in clinical …
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Evaluating deep learning for enhanced breast cancer diagnosis: a comparative analysis of CNN architectures
… various sectors, including healthcare. In breast cancer care, AI's ability to analyse vast datasets and extract complex patterns from medical images has the potential to transform diagnostics and treatment strategies. Breast cancer remains one of the most prevalent cancers affecting women …
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Elucidation of the pathways underlying the spectrum of cancers affecting different tissues in lynch syndrome
… individuals to an increased risk of several cancers, particularly colorectal cancer (CRC) and endometrial cancer (EC). LS arises from constitutional (“germline”) pathogenic variants affecting one of four DNA mismatch repair (MMR) genes. When coupled with somatic mutations (“second hits”) in …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
Triple-Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype, and patients still rely primarily on chemo-neoadjuvant therapy (NACT). Their poor prognosis is largely driven by extensive phenotypic heterogeneity, sustained by complex genetic and epigenetic interactions that are …
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Functional Interrogation Of Anti-Cancer Drug Resistance
… to achieve a precise map of each individual cancer’s genomic lesions, providing insights into the best strategies for treatment. However, these approaches will be undermined by cancer’s ability to resist upfront target inhibition (intrinsic resistance) as well as, in cases where tumors are …
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The Role of Inflammation and Nitric Oxide Synthase 2 in Triple-Negative Breast Cancer Metastasis
… resistance in triple-negative breast cancer (TNBC) patients. The tumor microenvironment (TME) comprises various cell types that play a role in tumor survival and invasion by providing soluble factors such as pro-inflammatory cytokines IFN-γ, IL-1β, and TNF-α, which are known to drive …
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Validation of an aASPH-SNAP-tag fusion protein for immunodiagnosis of triple-negative breast cancer
Breast cancer is a serious health concern for women from as young as 20 years old and to this day is well known to be the leading cause of cancer incidences and mortalities in females. This disease is known as a heterogeneous disease that requires different systemic therapies, therefore early …
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A Screen For Peptides Targeting Chemoresistant Metastatic Triple-Negative Breast Cancer
<p>Cancer metastasis is the principal cause of most cancer-associated morbidities. While radiotherapy, hormone therapy, and novel therapeutic strategies, including immunotherapy, have shown promise in inhibiting tumor growth, chemotherapy remains the mainstay in the clinical management of …
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Decoding the regulatory role and epiclonal dynamics of DNA methylation in 1482 breast tumours
Breast cancer is a clinically and molecularly heterogeneous disease displaying distinct therapeutic responses. Although recent studies have explored the genomic and transcriptomic landscapes of breast cancer, the epigenetic architecture has received less attention. To address this, an optimised …
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Terminal uridyl transferases: TUT4/7-mediated RNA metabolism in cancer
… catalytic knockouts of TUT4/7 in two distinct cancer cell types to understand the mechanistic aspects of TUT4/7-mediated regulation in tumorigenesis. I observe cell type specific defects in cancer properties in the TUT4/7 double mutants. As the cell type specific differences in defects could be …
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