Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Cancer Resistance"”.
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Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
… eusocial, cold-blooded and with remarkable resistance to hypoxia, hypercapnia and acid-induced pain. Furthermore, NMRs are exceptionally long-lived and extremely cancer resistant. Few studies have attempted to explain the reason behind the NMR’s cancer resistance, but most prominently Tian …
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Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin
Colorectal cancer (CRC) is the third most common type of cancer and accounts for 8 % of cancer related deaths worldwide. While the likelihood of colorectal carcinogenesis increases with age, genetics and lifestyle are major predisposing factors. Treatment can be curative and promises a 39 – 65% …
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REGULATORY MECHANISM OF DUSP16 IN CANCER RESISTANCE TO PLATINUM-BASED THERAPIES
… of treatment for various solid tumours, and resistance to platinum-based therapies is the main limitation. In this study, the role DUSP16/MKP7 in cancer resistance to chemotherapy drugs was investigated. We observed that higher expression of DUSP16 in breast, colorectal, nasal pharyngeal, and …
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AN INQUIRY OF THE SR/CR MOUSE PHENOTYPE AND ADVANCES REGARDING THE SEARCH FOR AN ANALOGOUS HUMAN TRAIT
… our laboratory observed the unique occurrence of cancer resistance in a single BALB/c mouse. Subsequent breeding studies found that this trait, known as Spontaneous Regression/Complete Resistance (SR/CR) is heritable among 30 to 40 % of offspring in an autosomal manner, thus enabling extensive …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… that may contribute to the formation of drug resistance and allow systemic viral repopulation. ATP-binding cassette drug efflux transporters i.e., P-glycoprotein and breast cancer resistance protein, have been previously shown to efflux antiretroviral drugs at the level of blood-brain barrier …
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Tamoxifen: Mechanisms of Resistance
<p>The role of estrogen in breast cancer has been recognized for decades. The selective estrogen receptor modulator tamoxifen was the first targeted therapy for the treatment of breast cancer. It was also the first drug approved by the FDA for the reduction of breast cancer risk. While tamoxifen …
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Understanding The Role of Arglu1 In Interferon Signaling Activation In Breast Cancer
<p>In the U.S., the highest number of new cancer cases belongs to breast cancer in women, and this cancer also bears the second-highest death rate in women. Despite significant progress in breast cancer treatment that has been made in the past several decades, innovative and efficient therapies are …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… including P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), which are known to contribute to efflux of endogenous toxins and therapeutics from the CNS. Pgp and BCRP expression and activity are a crucial determinant of drug efficacy in the CNS and have been studied using …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
Pediatric cancers are the second leading cause of deaths in children after accidents. The last few decades have seen tremendous improvement in cancer patient survival because of development of targeted therapies. In neuroblastoma, a common childhood cancer, approval of anti-GD2 immune therapy has …
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ROLES OF SULFOTRANSFERASE ENZYMES IN TRANS-PLACENTAL DISPOSITION
… of sulfate metabolites. The multidrug resistance-associated proteins (MRPs) played a major role in the elimination of 4-nitrophenyl sulfate and acetaminophen sulfate across the basolateral (fetal-facing) and apical (maternal-facing) trophoblast membranes respectively. The breast cancer …
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… the function of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) using intestinal organoids derived from germ free and humanized mice. Typically, transport across the epithelial cell layers occurs by active transport and passive diffusion. Using mouse models that differ in …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… prolactin are associated with increased breast cancer risk and poor prognosis. Prolactin is also involved in breast cancer resistance to different chemotherapeutics. The overall goal of this project is to investigate potential pathways involved in prolactin induced resistance to DNA damaging …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… as anti-inflammatory, hepatoprotective and anti-cancer. Hepatocellular carcinoma (HCC) is the third leading cause of death worldwide. Previous reports have shown the ability of CUCS to inhibit the growth of hepatocellular carcinoma cell lines (HepG-2) significantly. Structural activity …
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Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
… that P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are the two major efflux proteins that restrict the entry of xenobiotics across BBB. Overexpression of these efflux pumps in brain tumors at the BBB further compromises brain penetration of anti-tumor agents. The …
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
… progression and metastasis, as well as inducing resistance to various cancer treatments including chemotherapy, radiotherapy and immunotherapy. Mechanistic understanding of how the tumor-stromal interaction contributes to tumor progression and therapeutic resistance will advance cancer therapies …
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… the mRNA levels of P-glycoprotein (P-gp), Breast cancer resistance protein (BCRP) and Multidrug resistance-associated protein (MRP) in placentas from women with GDM. I have demonstrated a reduction in P-gp mRNA expression among placentas from those women treated with metformin and insulin compared …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… major placental drug transporters, multidrug resistance gene product 1 and 3 (MDR1 and 3)/ABC subfamily B members 1 and 4 (ABCB1 and 4), multidrug resistance associated proteins 1 and 2 (MRP1 and 2)/ABCC1 and 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term …
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Optimization of molecular tools for high-throughput genetic screening
… to identify therapeutic targets to circumvent cancer resistance to treatment in two different contexts. To overcome the shortfalls of single target therapy, I have developed multiplexed multidimensional shRNA screening strategy, where two genes are knocked down simultaneously in each cell. This …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… at the expression and regulation levels impact cancer susceptibility and phenotypic adaptation. Through the use of two distinct model rodent clades: mice species and African mole-rats, this research offers insights into the molecular drivers of evolution and disease susceptibility across …
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