Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Cancer Genomics"”.
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Algorithms for infection and cancer genomics
The student, Palash Sashittal, submitted this Thesis for approval on 2021-07-19 at 11:33.
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Computational methods for personalized cancer genomics
In recent years, cancer treatment strategies have moved towards personalized approaches, specifically tailoring cancer treatments on a single-patient basis using molecular profiles from the patients’ tumor genomes. Knowledge of a patient’s molecular profile can be used to 1) identify the disease …
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Bayesian Kernel Models for Statistical Genetics and Cancer Genomics
… trait loci (QTL) mapping studies, and cancer biology association studies. Lastly, we will also explore the potential of these approaches in radiogenomics, a brand new subfield of genetics and genomics that focuses on the study of correlations between imaging or network features and …
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Methods for Systematic Exploratory Analysis of Gene Expression Data with Applications to Cancer Genomics
… relevant insights into complex diseases such as cancer.</p>
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Genetic ancestry and population health: elucidating the relative role of African genetic ancestry in cancer genomics and the broader implications for racial health disparities in cancer
Racial health disparities in cancer remain a persistent and deeply rooted issue disproportionately affecting minoritized populations in the United States. Among these groups, individuals of African ancestry, particularly African Americans, face some of the most severe outcomes, including higher …
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Deciphering the heterogeneity and spatial architecture of tumors
Cancer is caused by the accumulation of somatic mutations that form distinct populations of cells, called clones. The resulting intra-tumor heterogeneity evolves temporally, as well as spatially, and is the main cause of relapse and resistance to treatment. With decreasing costs in DNA sequencing …
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DawnRank: discovering personalized driver genes in cancer
Large-scale cancer genomic studies have revealed that the genetic heterogeneity of the same type of cancer is greater than previously thought. A key question in cancer genomics is the identification of driver genes. Although existing methods have identified many common drivers, it remains …
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Clinical Applications of Genomic Analyses in Prostate Cancer
Prostate cancer is a leading cause of cancer-related death globally and is characterised by significant intra- and inter-patient genomic heterogeneity. This heterogeneity manifests as variable disease presentations ranging from indolent cancers for which no treatment is needed to aggressive disease …
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Genome Variation Across Cancers Scales With Tissue Stiffness--An Invasion-Mutation Mechanism
Analysis of published cancer genome sequencing data reveals that cancers arising in stiff tissues, such as lung and skin, exhibit more than 30-fold higher mutation rates than those arising in soft tissues, like marrow and brain. This scaling relationship suggests a possible mechanical source of …
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Bioinformatics analysis of epigenetic variants associated with melanoma
The field of cancer genomics is currently being enhanced by the power of Epigenome-wide association studies (EWAS). Over the last couple of years comprehensive sequence data sets have been generated, allowing analysis of genome-wide activity in cohorts of different individuals to be increasingly …
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Integrated Machine Learning and Bioinformatics Approaches for Prediction of Cancer-Driving Gene Mutations
<p>Cancer arises from the accumulation of somatic mutations and genetic alterations in cell division checkpoints and apoptosis, this often leads to abnormal tumor proliferation. Proper classification of cancer-linked driver mutations will considerably help our understanding of the molecular …
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Prevalence and prevention of large-scale somatic copy number alterations
… both CNVs and aneuploidy are widespread in cancer and also reported to be prevalent in select untransformed tissues. In order to reconcile these discrepant observations and understand how genomic imbalance influences disease, it is necessary to perform directed analyses of genomic stability …
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Roles for the polycomb group protein BMI1 in lung adenocarcinoma progression and maintenance
… implicated as an oncogene in a variety of human cancers. During normal development, Bmil acts as part of a transcriptional repressive complex that regulates processes such as stem cell self-renewal, cell-fate commitment, and proliferation. During tumorigenesis, many cancers co-opt these core Bmil …
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Tumor-penetrating delivery of small interfering RNA therapeutics
Efforts to sequence cancer genomes have begun to uncover comprehensive lists of genes altered in cancer. Unfortunately, the number and complexity of identified alterations has made dissecting the underlying biology of cancer difficult, as many genes are not amenable to manipulation by small …
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Pan-Cancer Analysis of Non-Coding Driver Mutations
Cancers are caused by genomic alterations known as drivers. As drivers have broad applications in precision oncology, their discovery has become one of the central motivations for cancer genomics. At present, the majority of drivers have been found in the ~2% protein-coding regions. Despite an …
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Altered Ovarian Cancer Metabolism Increases Neuronal N-Acetylaspartate to Promote Tumor Growth
… metabolism is a well-established trait in many cancers, and is an emerging hallmark of cancer. Recent resurgence of cancer metabolism studies has identified dysregulated metabolic pathways that produce novel oncometabolites in various cancers. However, large scale studies of dysregualted high …
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Integrating Functional Genomics with Systems Biology to Discover Drivers and Therapeutic Targets of Human Malignancies
… functional RNAi screens with systems biology of cancer genomics to tailor potential therapeutics for reversal of drug-resistance or treatment of aggressive tumors. I developed a series of algorithms and tools to deconvolute, QC and post-analyze high-throughput shRNA screening data by …
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NOVEL APPROACHES IN GENETIC VARIANT DISCOVERY AND CLASSIFICATION TACKLING UNSOLVED PROBLEMS IN CANCER CLINICAL GENOMICS
… trials addressing clinical needs in clinical cancer genomics, on ovarian and breast cancers and myeloproliferative neoplasms (MPN) who did not previously show positivity for known MPN genetic drivers (“triple negative disease”). In the latter study, we found a high prevalence of mutations in a …
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Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies
… biological processes, including diseases like cancer. Through our accumulated understanding of cancer genomics, targeted therapies, which inhibit the specific driver oncogenes and pathophysiological processes that underlie cancer progression, have been developed. However, in modern precision …
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Utilizing the IN4MER CRISPR/CAS12A Multiplex Knockout Platform To Investigate Synthetic Lethality in the Human Genome
… technologies and the development of targeted cancer therapies have significantly advanced our understanding of cancer genomics and prolonged patient survival. Despite these advances, durable response remains difficult to achieve in the clinic. The concept of synthetic lethality has gained …
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