Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Cancer Driver"”.
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Inferring context-specific essentiality networks using large-scale CRISPR-KO screens
… offer insights into vulnerabilities of different cancer types and provide promising targets for personalized cancer therapies. However, the challenge is to systematically identify and define those context-essential genes and to understand how cellular phenotype and interaction networks are altered …
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Prevalence and fate of pro-oncogenic clones in the human colon
… as a patchwork of mutations. The detection of cancer-driver mutations in the normal human colonic epithelium had been so far limited. Using immunohistochemistry and sequencing methods, and by screening a large number of patients and crypts, pro-oncogenic clones were detected for eight …
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Tissue adaptations to colitis influence neoplastic risk through clonal interaction
Despite a significant fraction of worldwide cancer cases being linked to chronic inflammation, full understanding of the neoplastic process in this context is lacking. The profound tissue remodelling described in chronic inflammatory diseases suggests that alteration of reciprocal signalling …
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Integrated Machine Learning and Bioinformatics Approaches for Prediction of Cancer-Driving Gene Mutations
<p>Cancer arises from the accumulation of somatic mutations and genetic alterations in cell division checkpoints and apoptosis, this often leads to abnormal tumor proliferation. Proper classification of cancer-linked driver mutations will considerably help our understanding of the molecular …
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Pan-Cancer Analysis of Non-Coding Driver Mutations
Cancers are caused by genomic alterations known as drivers. As drivers have broad applications in precision oncology, their discovery has become one of the central motivations for cancer genomics. At present, the majority of drivers have been found in the ~2% protein-coding regions. Despite an …
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A Study Of Computational Problems In Computational Biology And Social Networks: Cancer Informatics And Cascade Modelling
… in computational biology and social network: cancer informatics and cascade model-ling. In cancer informatics, identifying specific genes that cause cancer (driver genes) is crucial in cancer research. The more drivers identified, the more options to treat the cancer with a drug to act on that …
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Transcription Factor-Centric Approaches to Identify Regulatory Driver Mutations in Cancer
<p>Most previous efforts to identify cancer driver mutations have focused on protein-coding genes. In recent years, the decreasing costs of DNA sequencing have enabled whole-genome sequencing (WGS) studies of thousands of tumor samples, making it possible to systematically survey non-coding regions …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… expression and is reported as a newly identified cancer driver gene. Replication stress (RS) threatens DNA replication fidelity and stability of the genome. Recently, a small number of AU-RBPs have emerged as key figures in the maintenance of genome integrity through mechanisms that govern the …
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Discovery of Immunogenic Neopeptides from Chimeric RNAs to Develop Peptide and mRNA Vaccines for Lung Cancer Treatment
Non–small cell lung cancer (NSCLC) accounts for nearly 80% of lung cancer cases and exhibits a median survival of less than one year following diagnosis. A relatively unexplored avenue of immunotherapy for specific cancers may lie in chimeric RNAs that separate cancerous cells from their …
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DNA G-quadruplex structures in human cancer cells
… present new opportunities for targeting in anti-cancer therapeutic interventions with small molecules. In this thesis, I expand the G4-profiling toolkit to better understand the biological roles of G4s, and potentially offer practical insights for G4-targeting drug development. First, …
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Polyclonal interactions in intestinal tumorigenesis
… sequence posits that colorectal cancers result from the stepwise accumulation of mutations in a number of cancer driver genes, with mutations in the tumour suppressor gene \textit{APC} thought to be necessary and sufficient for transformation. However, large-scale sequencing …
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
… mRNA decaying. ZFP36L1 has emerged as a breast cancer driver gene, exhibiting tumour-suppressing properties. Notably, ZFP36L1 has been reported to be significantly mutated and downregulated in various tumour types. In our comprehensive study, we identified the novel role of the ZFP36L1 gene in …
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Identifying unique cell states in early liver oncogenesis with transcription coupled repair
Many cancers, such as the main form of primary liver cancer hepatocellular carcinoma (HCC), typically arise in tissues with a high number of genetic mutations which drive cell growth aberrantly. These mutations appear to precede tumour initiation, as DNA sequencing has shown that cancer driver …
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Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling
Cancer is a multistep process reflecting genetic alterations that drive progressive transformation of normal cells into highly proliferative malignant cells. Deregulation of cellular signalling is one of the key traits in cancer, allowing cells to breach anticancer defence mechanisms. The most …
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Multicomponent Complexes, Structural Proteomes, Drug Discovery For Cancer Gene Census And SARS CoV-2
… actual biological assembly. There are two main drivers for computational structural modelling: first, to reduce the colossal sequence- structure gap, and second, to understand the impact of mutations in human cancer and new variants from viruses on the protein structure. The Catalogue of Somatic …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… di adenocarcinoma del colon (COAD) del The Cancer Genome Atlas (TCGA) e nei modelli cellulari. La caratterizzazione molecolare delle linee cellulari di carcinoma colorettale è stata eseguita utilizzando piattaforma ad alta risoluzione SNP array 6.0. Gli effetti antitumorali del …