Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Cancer Cell Death"”.
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. Dysregulation of this process has been linked to human diseases including immune disorders, neurodegenerative muscular diseases and cancer.</p> …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 expression is silenced in basal like …
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Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin
In multicellular organisms, proper control of cell death is important for processes such as embryonic development and turnover of adult tissues. Misregulation of cell death contributes to many diseases, including cancer. Human cancers frequently show defects in their ability to initiate or execute …
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Effects of Green Tea Extract (GTE) for Normal and Cancer Cell Death by Radiation
"- 국문요약 - 정상 및 종양세포에서 녹차 추출물이 방사선에 의한 살상에 미치는 영향 녹차추출물의 항산화 및 항암 효과는 여러 논문에서 보고되고 있으며 또한 감마선에 의해 유도된 E-Coli DNA 절단에 대한 보호효과가 있음이 보고되었다. 일본에서 보고된 암 예방 및 암 재발 감소효과와 앞서 실행된 상당수의 실험연구를 근거로 녹차추출물의 암 예방 물질로서의 가능성을 알아보기 위한 임상연구가 진행중이다. 본 연구에서는 방사선을 조사한 정상세포와 종양세포에서 녹차추출물의 효과를 알아보고자 하였다. 본 실험에서는 마우스의 정상 소장 …
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How activating the protective and cytotoxic anticipatory unfolded protein response controls transcription and cancer cell death
Embargo set by: Seth Robbins for item 123454 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system
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Echogenic Liposomes For Nitric Oxide Delivery and Breast Cancer Treatment
… as a carrier for drugs and antitumor agents in cancer chemotherapy. Echogenic liposomes (ELIP) have the potential to entrap air or bioactive gas to enhance acoustic reflectivity in ultrasound and are used as a contrast agent. The innovative part of this study is based on a novel concept to …
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Evidenze molecolari del ruolo antiproliferativo e pro-apoptotico della clusterina in cellule epiteliali prostatiche umane
… properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis. Dis-regulation of CLU expression occurs in many cancer types, including prostate cancer. The role that CLU plays in tumorigenesis is still unclear. We found …
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Mitochondria-Endoplasmic Reticulum Contact Sites: Regulation and Roles in Coordinating Cell Fate Decisions
… signalling platforms, which are required for cellular processes such as lipid metabolism, mitochondrial dynamics, mitochondrial Ca2+ signalling and apoptosis. MERCs are vital in coordinating cell fate decisions and their deregulation is associated to the aetiology of several diseases including …
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Engineered Platforms for the Development of Electroporation-based Tumor Therapies
Cancer is a complex and dynamic disease that is difficult to treat due to its heterogeneous nature at multiple scales. Standard therapies such as surgery, radiation, and chemotherapy often fail, therefore superior therapies must be developed. Electroporation-based therapies offer an alternative to …
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In-depth bioinformatics analysis of the phosphoproteome of triple negative breast cancer treated with a tumor selective NQO1 bioactivatable drug
… in the proteome of triple negative breast cancer cells in response to a novel bioactivated anti-cancer agent IB-DNQ (isobutyl-deoxyniboquinone). NQO1 or NADPH:quinone oxidoreductase-1 is a detoxifying enzyme overexpressed in many solid tumors and low expression in normal cells. IB-DNQ is …
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Mechanistic and Therapeutic Insights for Epigenetic Regulation in Cancer Development
… inhibition can shift this balance in favor of cancer cell death. Collectively, these studies provide new insights for developing strategies to overcome resistance to BET bromodomain inhibitor therapy for subverting cancer cell survival.
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Development of Quantitative Optical Coherence Tomography Methods for Cell Death Detection
Current clinical cancer treatment monitoring methods rely largely on measurements of tumour volume to assess treatment efficacy several weeks to months after the start of therapy. The development of early monitoring methods to determine a patientâ s response within the first days of a new treatment …
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LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is an aggressive primary liver malignancy characterized by poor prognosis, limited therapeutic options, and frequent resistance to conventional treatments. Metabolic reprogramming, particularly involving mitochondria, is a hallmark of cancer and represents a potential …
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RNA interference targeting Glucose-Regulated-Protein 78 induces HepG2 cell Apoptosis
<p>Cancer is a complex genetic disease that is driven by genetic mutations resulting in chronic, inappropriate cell proliferation. Many current cancer therapies lack specificity towards tumor tissues, ultimately leading to adverse side effects and limited clinical efficacy. Recently, selective …
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Computational Molecular Docking Models and Design of Diarylpentanoids for the Androgen Receptor
… the development and progression of prostate cancer through different mechanisms, including over-expression and mutation of the AR. Therefore, the AR is a prominent molecular target in the clinical management of prostate cancer. However, all therapeutic modalities targeting the AR, including …
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Nanoclusters for Cancer Therapy: Assesment of Their Reactive Oxygen Species Generation and Stability
… materials that can be used to identify and treat cancer. Nanoclusters or "clusters" are small arrangements of metal atoms protected by an exact number of ligands. Clusters have unique properties that make them useful for a variety of biomedical applications including bioimaging, photodynamic …
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Anti-Nucleic Acid Antibody-Mediated Cross Presentation of An Antigen and Its CD8+ T Cell Activation
… to the cross-presentation pathway in dendritic cells using a number of different carriers has been attempted to further understand the mechanisms underlying cross-presentation and to develop therapeutic tumor vaccines. The present study reports a new antigenic carrier molecule: a single chain …
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Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds
In the quest for novel anticancer small molecules, one of two major complementary strategies, either a target- or phenotype-based approach, is generally utilized. Target-based approaches, in which targets are first identified based on their cellular function and an inhibitor is subsequently …
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Hijacking Cancer Signaling: First-in-class JPRK-targeting Ligands for Fibrolamellar Hepatocellular Carcinoma
… patient derived xenografts. Fibrolamellar hepatocellular carcinoma is a rare un-treated liver cancer driven by a fusion kinase known as JPRK, a mutant of protein kinase A (PKA). Targeting this fusion kinase selectively is challenging due to the structural similarity of the catalytic domain to …
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Synergistic growth inhibition and enhancement of cell death by combination of Melanoma Differentiation Associated gene-7 (MDA-7/IL-24) and cisplatin in ovarian cancer cell lines
Ovarian cancer is the most lethal gynecological malignancy among women. The current first-line treatments for ovarian cancer are cisplatin, carboplatin and paclitaxel. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully …
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