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Showing 1 to 20 of 35 for “"Cancer Cachexia"”.
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Insulin resistance in cancer cachexia and metabolic syndrome
… the incidence of metabolic-related diseases. Cancer cachexia (CC) and Metabolic syndrome (MetS) are both multifactorial highly complex metabolism related syndromes, whose etiology is not fully understood, as the mechanisms underlying their development are not completely unveiled. Nevertheless, …
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Purification and characterisation of two cancer cachexia factors
Cachexia is a wasting phenomenon that often accompanies malignant disease. Its manifestation is associated with shortened survival and reduced responsiveness to anti-tumour therapy and as yet there is no established, effective amelioratory treatment. The MAC 16 model of cancer cachexia has been …
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Cellular signalling pathways involved in muscle atrophy in cancer cachexia
Cancer cachexia encompases severe weight loss, characterised by the debilitating atrophy of adipose and skeletal muscle mass. Skeletal muscle proteolysis in cancer cachexia is mediated by a sulphated glycoprotein with a relative molecular mass of 24kDa, termed Proteolysis-Inducing Factor (PIF). PIF …
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Investigation into the mechanisms responsible for muscle atrophy in cancer cachexia
Cachexia inducing tumours are known to produce a glycoprotein called proteolysis inducing factor (PIF), which induces skeletal muscle atrophy via increased protein degradation and decreased protein synthesis. The objective of this study was to investigate the signalling pathway by which PIF reduces …
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The Potential of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) in Cancer Cachexia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The mode of action of a lipid mobilising factor in cancer cachexia
Cachexia is characterised by a progressive weight loss due to depletion of both skeletal muscle and adipose tissue. The loss of adipose tissue is due to the production of a tumour-derived lipid mobilising factor (LMF), which has been shown to directly induce lipolysis in isolated epididymal murine …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… concurrently with multiple pathologies such as cancer and extended bed rest. Atrophy reduces overall quality of life while increasing morbidity and mortality. Currently, efficacious therapeutic interventions to treat and prevent muscle wasting in all its forms are lacking, however if conserved …
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The role of Protein Degradation in Cancer Cachexia in Female Tumor Bearing Mice
<p>Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional …
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Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
<p>Cancer cachexia is a complex wasting condition associated with the loss of skeletal muscle and fat mass. Muscle wasting exhibits an imbalance in the rate at which proteins are synthesized and degraded, referred to as protein turnover. Our laboratory has shown the ApcMin/+ mouse, a model of …
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Differential BCAA Metabolism in Tissues of Tumor-Bearing Mice: A Path to Understanding Cancer Cachexia
Cancer cachexia is a complex syndrome marked by muscle and fat loss, often resistant to nutritional support. While branched-chain amino acids (BCAAs) stimulate muscle protein synthesis, BCAA-targeted therapies have shown inconsistent results. In this study, a C26 colon cancer mouse model was used …
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The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover
<p>Cancer cachexia is defined as the unintentional loss of skeletal muscle mass with or without fat loss that cannot be reversed by conventional nutritional support. Cachexia occurs in ~20% of cancer patients. More specifically, 50% of lung cancer patients, the most common cancer worldwide, develop …
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Sex Differences in Cancer Cachexia and a Novel Mitochondrial Target for Cancer-Induced Muscle Wasting
<p>Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or …
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Sex-Based Differences in ACVR2B and GRB10 Expression in Skeletal Muscle During Induced Cancer Cachexia and Disuse
… in different muscle atrophy disorders such as cancer cachexia and disuse. These forms of muscle atrophy produce distinct wasting pathologies that are influenced by biological sex. Activin receptor type-2B (ACVR2B) and Growth factor receptor-bound protein 10 (GRB10) have been identified as genes …
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The Effect of Sex and Exercise Training During the Progression of Cancer Cachexia In the Apc Min/+ Mouse
<p>Cachexia is a complicated metabolic syndrome associated with underlying chronic disease and characterized by the loss of body weight and muscle mass. The condition is associated with elevated levels of pro-inflammatory cytokines such as IL-6, disrupted glucose and fat metabolism, and loss of …
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Investigate the nutritional status, including body composition, of oncology patients attending an outpatient clinic at Groote Schuur hospital: a cross-sectional study
Background There is an increase in cancer prevalence globally with an increase in cancer mortality in South Africa. Malnutrition, cancer cachexia and sarcopenia are conditions commonly experienced by people with cancer. Not only is there a deterioration of nutritional status, but these conditions …
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