Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Cancer -- Genetic aspects"”.
-
Characterisation of the EDD gene and its role in cancer.
… the possible involvement of EDD in human cancer, several cancer types were analysed for allelic gain or loss (allelic imbalance, AI) at the EDD locus. AI of the EDD locus was most frequent in the serous subtype of ovarian cancer (16/22, 73%) and common in other cancers, including breast …
-
Gain-of-Function Effects of Mutant p53 Explored Using a Three-Dimensional Culture Model of Breast Cancer
… a three-dimensional (3D) culture model of breast cancer. When placed in a laminin-rich extracellular matrix, non-malignant mammary epithelial cells form structures highly reminiscent for many aspects of acinar structures found in vivo. On the other hand, breast cancer cells, when placed in the …
-
Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer
Prostate cancer is the second leading cause of cancer death in American men, yet despite the prevalence of this disease, there is a distinct lack of prognostic biomarkers for estimating the likelihood of prostate cancer aggressiveness. The loss of cell-cell adhesion is frequently associated with …
-
THE EFFECTS OF RETINOIC ACID ON CELLULAR TRANSFORMATION AND TUMORIGENESIS INVOLVING CELLS WITH KNOWN ONCOGENES (VITAMIN A, RETINOIDS, RETROVIRUS)
Vitamin A is known to have an important role in cellular differentiation and proliferation. In addition to regulating normal cellular processes vitamin A has also been shown to possess potent antineoplastic activity. The work in this dissertation characterizes the role of retinoic acid (RA) in …
-
Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
… of the alternative splicing of the PKM gene in cancer cells, while the second part investigates the physical connections between the transcriptional apparatus and splicing factors. Cancer cells uniformly alter key aspects of their metabolism, including their glucose usage. In contrast to …
-
Analysis of The RING Domain And BRCT Repeats of BRCA1
Mutations within BRCA1 often contribute to breast cancer susceptibility. Many of these mutations cluster within two highly conserved regions that may be important for BRCA1's functions: the RING domain and the BRCT repeats. BRCA1's RING domain has E3 ubiquitin ligase activity, which is greatly …
-
Psychological and Sociodemographic Predictors of Psychological Distress in BRCA1 and BRCA2 Genetic Testing Participants within a Community Based Genetic Screening Program
… in BRCA1 and BRCA2, the first two breast cancer susceptibility genes identified, carry as much as an 85% lifetime risk of developing breast, ovarian or other cancers. Genetic testing for mutations in these two genes has recently become commercially available. There have been varying …
-
Analysis of referrals to a cancer genetics service
… referrals for Welsh-domicilled patients to the Cancer Genetics Service for Wales (CGSW) in order to establish what referral patterns exist. CGSW has a patient population of 10,878 first referrals over the eight year period, 1998 to 2006. These data are combined with data on deprivation, GP …