Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"Cancer -- Chemotherapy."”.
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Endocrine Effects of Cancer Chemotherapy
… thesis explores the pharmacological effects of cancer chemotherapy on endocrine organs, emphasizing both therapeutic advantages and adverse effects. It categorizes chemotherapeutic agents based on their mechanisms of action and their impact on endocrine function, highlighting both intended …
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Pharmacology of gastric cancer chemotherapy
… pharmacotherapies and other therapies of gastric cancer
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Conditioned food aversions in cancer chemotherapy
… research investigated the following: (a) Can chemotherapy patients acquire conditioned aversions to novel as well as familiar foods which are consumed prior to postchemotherapy nausea? (b) Does nausea facilitate aversions, and if so, what aspects of nausea are important? (c) Do aversions to …
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The Membrane as a barrier or target in cancer chemotherapy
The overall aim of the project was to investigate the role of the cell membrane as a barrier and/or target for drug action and relate this to the development of strategies for overcoming multiple drug resistance (MDR). The effects of doxorubicin on various bacterial strains expressing different …
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Pharmacological determinants of oxaliplatin neurotoxicity in patients undergoing cancer chemotherapy
Oxaliplatin-based chemotherapy has become the standard treatment for gastrointestinal cancers. Oxaliplatin-induced neurotoxicity often compromises treatment delivery and causes long-lasting neurological deficits that negatively impact upon patient's quality of life. Calcium and magnesium (Ca/Mg) …
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The Development of Anticipatory Nausea in Cancer Chemotherapy: A Prospective Longitudinal Analysis
… the phenomenon of anticipatory nausea in cancer chemotherapy patients has been hampered by the use of retrospective, cross-sectional research designs. The present research investigated the development of anticipatory nausea using a prospective, longitudinal approach. Eighty new …
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Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
… of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and molecular alterations have been implicated in the development of MDR, including activation of efflux transporters and metabolizing enzymes in response to therapeutic agents. Therefore, the primary …
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Identifying a transcriptional signature for cell sensitivity to the cancer chemotherapy agent, BCNU
Many organisms have evolved DNA damage response mechanisms to deal with the constant damage to DNA caused by endogenous and exogenous agents. These mechanisms activate cell cycle checkpoints to allow time for DNA repair or, in the case of severely damaged DNA, initiate cell death mechanisms to …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
Chemotherapy and radiotherapy target neoplastic cells. However, they also adversely affect progenitor cells throughout the healthy alimentary tract, resulting in severe ulceration and pain. This affects around 500,000 patients annually. The aims of the present research were to identify the main …
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Mathematical modelling in the scheduling of cancer chemotherapy treatment when drug resistance is present.
… agents when employed in the fight against cancer often yield a sub-optimal outcome due to the development of drug resistance. Some biological background to the problem of cancer and its treatment is given in Chapters 1 to 3 and some relevant existing mathematical models are described in …
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Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells
… shown that NEIL3 is highly expressed in various cancer cell lines when compared with normal counterparts. Furthermore, high expression levels of NEIL3 were associated with development of metastases in patients with primary malignant melanoma. However, no one has looked at the expression of NEIL3 …
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In vitro studies on the cellular mechanisms of resistance to cytotoxic compounds with special reference to multidrug resistance and cancer chemotherapy
… drugs is a major obstacle in the treatment of cancer. When resistance develops to natural product, lipophilic antitumour agents the resistance is also conferred to structurally and functionally unrelated compounds. This phenomenon is termed multidrug resistance (MDR). The development of MDR in …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
… from tumour cells plays an important role in cancer drug resistance. It is essential that chemotherapeutic drugs are retained within target cells for increased efficacy in inducing apoptosis and as microvesiculation influences drug retention, this study has focused on modulating …
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Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency
… it is estimated that 1,735,350 new cases of cancer and 609,640 deaths from the disease will be diagnosed in the United States alone. Conventional chemotherapy is by far the most successful category of clinical oncology, having cured (complete remission (CR), without return) or provided …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… fatigue, especially in fatigue associated with cancer and cancer chemotherapy treatments, known as cancer-related fatigue (CRF). Moreover, accumulating evidence shows that peripheral MCP-1 expression is increased with many diseases, disorders and treatments, including cancer chemotherapy, that …
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Autologous Stem Cell Transplant: Factors Predicting the Yield of CD34+ Cells
… the last hope for the survival for many cancer patients. The CD34+ cell content of a collection of stem cells has appeared as the most reliable indicator of the quantity of desired cells in a peripheral blood stem cell harvest and is used as a surrogate measure of the sample quality. …
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Lithium-Carbonate as a Protectant Against Chemotherapy-Induced Myelosuppression
Lithium carbonate has been used as an adjunct to cancer chemotherapy to lessen the dose-limiting myelosuppressive effects of several anti-cancer drugs. Its mechanism is unknown, but several possible sites of action have been considered. Lithium causes a neutrophilia and may protect the bone marrow …
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An application of genetic algorithms to chemotherapy treatment.
… present work investigates methods for optimising cancer chemotherapy within the bounds of clinical acceptability and making this optimisation easily accessible to oncologists. Clinical oncologists wish to be able to improve existing treatment regimens in a systematic, effective and reliable way. …
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