Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Cancer/testis"”.
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Defining Tumorigenic Contributions of Meiotic Cancer-Testis Antigens
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Examining the Regulation and Function of Cancer Testis Antigens
Cancer Testis Antigens (CTAs) are a class of genes whose expression is generally restricted to the testis, but are reactivated in cancer cells. The function and regulation of many CTAs are unknown, however several CTAs have been shown to impact tumor cell fitness and correlate with poor prognosis. …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… are only otherwise required for meiosis. These Cancer Testes Antigens (CTAs) have been found to play critical roles in multiple cellular processes when aberrantly expressed in cancer. Here I found that the CTAs SPO11, GAGE and HORMAD1 play critical roles in cell survival, modulating response to …
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Investigation of the cancer testis antigen lactate dehydrogenase C as a CD8 T cell target
… design. In our cohort of HGSC cases, the cancer testis (CT) antigen lactate dehydrogenase C (LDHC) is expressed in 76% of tumours (22/29). As LDHC presents with tumour specificity in women, I hypothesize that LDHC is an immunogenic target in HGSC patients, and that LDHC-specific T cells …
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Investigating the Functional Contributions and Tumorigenic Potential of Cancer/Testis Antigens and Their Interacting Partners
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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HAGE, a novel cancer/testis antigen with strong potential as a target for immunotherapy against cancers
… discovered, often belonging to the so-called cancer/testis (CT) gene family. In a search for novel epitopes from potential tumour target antigens, HAGE, a CT antigen, has been studied. It was first identified in a sarcoma and has since been reported in several carcinomas and leukaemias at the …
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Development of computational methods for custom protein arrays analysis : a case study on a 100-protein ("CT100") cancer/testis antigen array
… a platform to assay the serological response of cancer patients to at set of selected cancer testis antigens in order to infer a diagnosis value or to assess the patient responses to particular treatments. However, the acquisition of the array data is subject to bias and noise. Therefore, array …
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Investigation of the immunological differences between granulocytes from healthy donors and breast cancer patients, with respect to the cancer testis antigen, CTCFL
… was also recently established as a member of the cancer-testis (CT) gene family as its activation in somatic cells was found to be associated with the development of many types of cancer, including breast cancer. This presents it as an attractive biomarker for cancers dia gnosis/prognosis and …
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Development and implementation of ontology-based systems for mammalian gene expression profiling
… and exploring the mouse orthologs of human cancer/testis genes.Model organisms represent an important resource for understanding the fundamental aspects of mammalian biology. Mapping of biological phenomena between model organisms is complex and if it is to be meaningful, a simplified …
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Molecular and functional analysis of the tumour antigen T21
… antigens that are distinctively expressed in cancer and can be used effectively to initiate or enhance immune responses. T21 (Testis clone 21) was identified as a member of cancer/testis antigen (CTAs) family of proteins using a modified SEREX technique and can be considered a promising …
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Proteomic studies on patient responses to chemotherapy, radiotherapy and immunotherapy in cancers
… evidence that the aberrant expression of cancer-testis (CT) antigens - a family of ca. 150 proteins that are both autoimmunogenic and mainly restricted to tumours in various types of human cancers - makes them attractive immunotherapy targets, as well as possible cancer diagnostic markers. …
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Molecular and cellular expression of novel genes associated with breast cancer
An improved and individualised breast cancer care can be pursued with the use of tumour markers that are associated with risk assessment, diagnosis, prognosis, prediction of treatment outcome, monitoring of the disease and development of novel therapies. As such, this study proposed to characterise …
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Molecular expression and immunotherapeutic potential of the novel tumour associated antigen T21
… system, could provide opportunities to oppose cancer. A prerequisite of tumour immunotherapy lies in the identification of antigens that are distinctively expressed in cancer and can elicit immune responses in the tumour-bearing host. Testis clone 21 (T21) was first identified as a promising …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
Cancer/testis (CT) antigens are proteins whose expression is normally restricted to germ cells yet aberrantly activated in tumors, where their functions remain relatively cryptic. The transcription factor ZNF165, a CT antigen frequently expressed in triple-negative breast cancer (TNBC), was …
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Defining the functional role of MAGE-C1 in Multiple Myeloma
The expression of Cancer/Testis antigens (CTAs) in various cancers, including multiple myeloma, makes them attractive targets for therapy and biomarker development. Despite intensive studies, their potential has not been fully realized due to lack of knowledge regarding their pathogenic role. To …
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A dynamic transcriptome technique for transcriptional profiling and gene regulatory network involving the helicase antigen (HAGE)
… is undermined by the continued prevalence of cancer and the limitations of these drugs. Therefore, it is possible signalling networks could be influenced by as yet unknown molecules or known mediators with function that have not yet been described. As a result of this, work must continue to …
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Structure and Function of KH Domain in DDX43 and DDX53 Cancer Antigen Helicases
DDX43 and DDX53 are two cancer/testis antigens that are overexpressed in various tumors, but absent or expressed at very low levels in normal tissues; therefore, both are proposed to be valid candidates for therapeutic targets. DDX43 and DDX53 belong to the DEAD-box RNA helicase family, and contain …
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Differential expression of C/T antigens and 5-HT receptors in normotensive and pre-eclamptic placentae, and their role in trophoblast invasion
Cancer/testis (C/T) antigens are a unique class of tumour associated proteins that are prominently expressed in cancer cells of different histological origin. Placenta is one of the three non-cancerous tissues known to express these antigens. During the first trimester (FT) of pregnancy, placental …
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