Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Calu-3"”.
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The novel role of epidermal growth factor (EGF) in the regulation of ion channels in the calu-3 submucosal cell line
… on ion transport in the submucosal cell line Calu-3, (ii) what the mechanisms are behind this, and (iii) if the effect of EGF was due to induction of gelatinase activity or a transactivation process. Functional investigations looking at ion transport were carried out by using short circuit …
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IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN
… actions. The human bronchial epithelial Calu-3 cells were used as monolayers to characterize the kinetics and mechanism of transport and/or uptake, and to assess the effects of such slow kinetics for Lipo-CPFX on its inhibition against lipopolysaccharide (LPS)-induced proinflammatory IL-8 …
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Innovatives liposomes for overcoming biological barriers
… of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. Studies continue with biocompatibility and in vivo tests.
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
… on initial telomere length and growth rate. Calu-3 had the fastest response time (11 days or as few as 2 population doublings) to see a change in growth rate and 32 population doublings for cell death in all cells. Calu-3, H1648 and HCC827 all showed reduced growth rate in the presence of …
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… at 1 mg/mL showed good cytocompatibility in Calu 3 cells with a cell viability of 87.5±4.7% after 24-hour exposure. Meanwhile, the 5% RNP and 10% RNP decreased the IC50 of resveratrol in Calu 3 cells after 24 hours from 213 ± 63 µM to 47 ± 30 µM and 48 ± 12 µM, respectively. This is a …
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Cationic lipid formaulation of short interference RNA (siRNA) for delivery to respiratory epithelial cells
… silencing in bronchial and alveolar cell lines Calu-3 and A549 revealed a dependency on high lipid/siRNA (+/-) charge ratio (> 8) compared to the delivery of pDNA complexes (0.5-1). Confocal microscopy and endocytic inhibitors studies indicated that the cellular uptake of siRNA/lipid complexes …
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Host Entry Factors for Human Coronaviruses
… tract, the primary site of infection. Using Calu-3 cells, I discovered that endogenous Transmembrane Protease Serine Subtype 2 is required for optimal SARS coronavirus entry. At physiological levels, this protease does not function redundantly with other known protease activators of SARS …
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NOVEL CINNAMIC ACID-BASED DEHYDROPOLYMERS FOR EMPHYSEMA: IN VITRO AND IN VIVO ASSESSMENT OF THEIR ACTIVITIES
… in chemical oxidation, lung epithelial (Calu-3) repression of pro-inflammatory nuclear factor κB (NFκB) upon its plasmid transfection and chromogenic substrate NE hydrolysis, respectively. The sulfated caffeic acid DHP, CDS was shown to be the most potent in all three assessments, …
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Monitoring Biological Events on Native Cell Membranes with Organic Bioelectronics
… from two cell lines: human lung epithelial Calu-3 cells and human embryonic kidney cells which overexpress the ACE2 receptor (HEK293-ACE2), respectively. The sensitivity of virus detection is further assessed by testing a range of viral particle concentrations; the detectable concentration …
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Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen: Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer Berücksichtigung der Plattenepithelmetaplasie
… Zellen der Linien 16HBE und CaLu-3 recht niedrige - und die an einer Luft-Flüssigkeits-Grenzschicht induzierten Metaplasie-Modelle („Multilayer“-Kulturen) sogar nur äußerst geringe - Widerstandswerte auf, deren Signifikanz überdies noch zweifelhaft blieb. Biochemische Befunde, …
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The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation by HSP-90
<p>The hypothesis of this project is that a functionally relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic …