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Showing 1 to 8 of 8 for “"Calsequestrin"”.
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
<p>Cardiac CSQ (CSQ2) is a multifaceted protein, capable of binding significant quantities of Ca2+ and altering ryanodine receptor activity at the junctional sarcoplasmic reticulum (SR). Little is known about the trafficking of CSQ2 from its unknown site of biosynthesis, which appears to be of …
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Molecular biology of cardiac sarcoplasmic reticulum proteins: studies on the structure and distribution of calsequestrin and phosopholamban
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
… ATPase (SERCA 1 and SERCA 2 respectively). Calsequestrin (Csq) and calmodulin (CaM) play regulatory roles in calcium handling. Changes in the levels of these proteins could explain alterations in calcium handling and subsequent muscle function. The purpose of this study was to use a genetic …
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Sarcoplasmic Reticulum Calcium Handling in Maturing Skeletal Muscle From Two Models of Dystrophic Mice
… receptor type 1 (RyR1), parvalbumin, and calsequestrin were determined by Western analysis. Two dystrophic mouse models were used, the mdx mouse which lacks dystrophin, and the mdx:utrophin-deficient (mdx:utrn<sup>-/-</sup>) mouse which also lacks utrophin, a protein homolog of dystrophin. …
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Junctional Sarcoplasmic Reticulum Protein Processing And Trafficking In Cardiac Tissue And Primary Cultured Cardiomyocytes
… an exclusive set of resident proteins. Cardiac calsequestrin (CSQ2) undergoes two co-translational modifications: N-linked glycosylation on 316Asn, and phosphorylation by protein kinase CK2 on a cluster of 3 serines in its tail. In the heart, CSQ2 molecules undergo extensive mannose trimming by …
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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… a linker between the SR calcium binding protein (calsequestrin) and RyRs, recent studies suggest the junctin may have a more complex role in regulating RyR activity and SR Ca2+ handling. In vitro studies have shown that addition of full-length junctin (FLjun) to the luminal domain of RyR directly …
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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… a linker between the SR calcium binding protein (calsequestrin) and RyRs, recent studies suggest the junctin may have a more complex role in regulating RyR activity and SR Ca2+ handling. In vitro studies have shown that addition of full-length junctin (FLjun) to the luminal domain of RyR directly …
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Membrane reconstitution studies on the irreversibility of inactivation of sarcoplasmic reticulum of rabbit skeletal muscle
… loss of the M45 calcium binding protein (calsequestrin). The removal of deoxycholate into the dialysate was studied by means of (Carboxyl-C¹⁴) -deoxycholate. The kinetics of removal indicate that approximately 0,15 mg DOC remained associated per mg of protein even after exhaustive …