Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Calreticulin mutations"”.
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… only in 2013 through the discovery of Calreticulin mutations in approximately 30% of patients with megakaryocytic neoplasias. The role of Ca2+ and glutamate pathways in megakaryocytic malignancies remains unknown but their oncogenic potential has already been demonstrated in other …
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Detection of the calreticulin type 1 and type 2 mutations in a group of myeloproliferative neoplasm patients using molecular methods
… (PMF) or myelofibrosis (MF). In 2013, somatic mutations at exon 9 of CALR, the gene that encodes for calreticulin, were discovered through whole-exome sequencing and targeted re-sequencing in patients with MPNs. Among these mutations, more than 80% of CALR mutated patients possessed one of only …