Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Calcium signalling"”.
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The Role of Calcium Signalling in Autophagy
Autophagy is a catabolic process that is important for degradation of cellular components, and for cell survival, and has also been associated with pathological disorders and tumour growth. Autophagy is a complex process; many factors and messengers converge to control steps along the autophagic …
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Studies of calcium signalling mechanisms in human platelets
… thrombosis and central to this role is cytosolic calcium (Ca2+) elevation. The two ways in which this can occur are release from intracellular Ca2+ stores and the entry of Ca2+ across the plasma membrane (PM). Changes in cytosolic Ca2+ are required to enable a variety of platelet responses. In …
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Modulation of calcium signalling in human sperm by nitric oxide
… of NO, the NO-mediated [Ca\(^{2+}\)]\(_i\) signalling pathways, the possible interaction of NO with progesterone (a product of cumulus) and its impact in the regulation of human sperm functions. Immunofluorescent staining revealed constitutive NOS in human cumulus. DAF-FM diacetate staining …
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Phosphate starvation alters calcium signalling in roots of Arabidopsis thaliana
… of P deficiency. The second messenger calcium (Ca2+) is known to signal in plant development and stress perception, and most recently its direct role in signalling nutrient availability and deficiency has been partially elucidated. The use of Ca2+ as a signal has to be tightly …
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Role of ryanodine receptors in neuronal calcium signalling and growth control
… as a messenger regulating a myriad of signalling events requires that the concentration of Ca<sup>2+</sup> ions in the cytoplasm be highly regulated. Capacitative Ca<sup>2+</sup> entry (CCE) or store-operated Ca<sup>2+</sup> (SOC) entry, whereby the depletion of intracellular …
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Investigating the clinical value of hyperactivation and intracellular calcium signalling of human spermatozoa and their value in drug screening
Confidential thesis. Abstract and full text under embargo until 12/03/2015.
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ROLE OF G9A IN SKELETAL MYOGENESIS
… HDAC5. This occurs through blocking of calcium signalling-dependent phosphorylation and cytoplasmic export of HDAC5. Furthermore, we show that G9a over-expression in Drosophila melanogaster results in a perturbation of muscle function by dysregulation of sarcomere genes and mitochondria …
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Elucidating the regulatory mechanisms of pterygium
… with transforming growth factor β on cell signalling and function of pterygial derived fibroblasts. Methods: Pure fibroblast cultures were established from cell outgrowths of pterygial tissue. Immunochemistry techniques were used to identify cell phenotype, tissue features and cell …
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Characterization of the Tetraspanin protein Tspan18
… regulate diverse processes such as cell signalling and fusion, intracellular trafficking, viral infection and cancer. The primary aim of this thesis was to study a previously uncharacterized tetraspanin, Tspan18. Unlike other tetraspanins, over-expression of Tspan18 in lymphocyte cell …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… to a diverse range of cellular processes and signalling events. However, recent findings have revealed several γ-secretase-independent presenilin functions, including calcium signalling, autophagy and apoptosis. We and others have previously reported members of the TNF receptor super-family as …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… ATP and have additional important roles in calcium signalling, apoptosis and lipid metabolism. Mutations in or loss of mitochondrial DNA (mtDNA) can cause neurodegeneration and has been linked to Parkinson‟s disease. However, the pathological consequences of mtDNA loss in neurons are very …
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Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… was to investigate the molecular mechanism of calcium (Ca2+) coupling mucus (MUC2) secretion in colonic goblet cells in situ, using an ex-vivo 3D model native human colonic crypt model system. Immunohistochemistry revealed the presence of cholinergic neurons in close proximity to the basal …
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Investigating the role of Neuronatin in neural development
… completely understood. For instance, in Xenopus, calcium signalling is known to play a pivotal role in neural induction but whether a similar mechanism occurs in mammals is unknown. As part of a wider study on genes regulating neural stem cell (NSC) development, we have discovered a novel role for …
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Ryanodine receptor expression in trophoblasts
… the mother and fetus. Within trophoblasts, calcium signalling proteins are richly expressed. Intracellular free calcium ions are a key second messenger, regulating various cellular activities. Transcellular Ca2+ transport through trophoblasts is essential in fetal skeleton formation. …
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Elucidating Astrocytic Diversity in Human Cerebral Organoids
… reveal that they differ in morphology, calcium signalling, synaptogenic and synaptic engulfment potential, consistent with their transcriptome. In addition, these two populations show distinct responses to neurodegeneration and physical injury linked to their reactivity status. These …
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
… plays a crucial role in regulating the signalling of the epidermal growth factor receptor (EGFR). The internalization of the EGFR can occur through different mechanisms. Clathrin-mediated endocytosis (CME) operates at all concentrations of EGF and in all cell contexts, directing the …
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Expression of sigma receptors in human cancer cell lines and effects of novel sigma-2 ligands on their proliferation
… their hydrophobicity nor their ability to effect calcium signalling in cells. I propose that the Hill slope of binding is inversely related to the efficacy of a ligand to inhibit metabolic activity of cancer cells. Furthermore, I offer an explanation as to why concentrations of sigma-2 ligands far …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… selectively express CYSLTR1 mRNA at high levels. Calcium signalling experiments revealed that Th2 cells respond selectively to leukotrienes compared to Thl cells, with a rank order of potency similar to that reported for CysL R (LTD4>LTC4>LTE4). This profile of leukotrienes responsiveness was …
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