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Showing 1 to 20 of 66 for “"Calcium release"”.
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Characterization of the sarcoplasmic reticulum calcium release channel in skeletal muscle
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The Role of Potassium as a Counterion During Calcium Release From the Sarcoplasmic Reticulum
… is great interest in the effect of Ca$\sp{2+}$ release on the electrical properties of the sarcoplasmic reticulum (SR) membranes since a voltage change may play an important role in muscle regulation. Hence the role of K$\sp{+}$ as a counterion during Ca$\sp{2+}$ release from the SR was …
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PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
… Ca2+ homeostasis, the L-type Ca2+ channels (calcium channel blockers). Other agents, like beta blockers, indirectly target various elements, including sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) and ryanodine receptors (RyRs). However, there are no pharmacological agents that directly and …
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Targeting Sequence and Function-Dependence of Subcellular Localization of Transient Receptor Potential Mucolipin Channels and Characterization of Engineered Molecule Probes For Detecting Lysosomal Calcium Release
… endolysosomal functions such as divalent cation release, luminal pH regulation, autophagy and vesicle trafficking. Interestingly, whereas TRPML1 is almost extensively localized in lysosomes, TRPML3 is typically found in both lysosomes and the plasma membrane (PM). It has been shown that TRPML3 …
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Discovery and Characterization of Genes Involved in Muscle Calcium Handling
Muscle tissue requires continuous cycling of calcium release and clearance to generate and sustain contraction. When the plasma membrane of a muscle fiber becomes electrically excited, a voltage sensor in the membrane, called the dihydropyridine receptor (DHPR), becomes activated and signals to the …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… expressed endoplasmic-reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influence many signaling pathways including those regulating apoptosis. IP3R activity is regulated by protein-protein interactions, including binding to proto-oncogenes and tumor suppressors to …
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
… large, endoplasmic reticulum (ER) intracellular calcium channels in excitable cells. RyRs are major cellular mediators of calcium-induced calcium release and crucial regulators of intracellular calcium homeostasis. Disruption of RyR function has been described in pathologies of dysregulated …
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The characterisation of alginate systems for biomedical applications
… were prepared as mixed salts such as sodium/calcium salts as Ca2+ ions are known to promote faster healing. The aims of this research were: 1- to provide a greater insight into the nature of binding between various ions (NaT, Ca2+ as well as Zn2+ and Ag+) and the polysaccharide molecules. …
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Novel Effects of Simvastatin on Uterine Fibroids
… manner mechanistically dependent upon apoptotic calcium release from L-type voltage-gated calcium channels. Thus, simvastatin possesses anti-tumor effects which are dependent upon the apoptotic calcium release machinery. For the in vivo studies, animals were treated with simvastatin vs vehicle …
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Arrhythmogenic potential of alpha-adrenoceptor stimulation in the rat heart
… stimulation enhances transsarcolemmal calcium ion influx and may induce sarcoplasmic reticulum calcium release. To assess the role of transsarcolemmal calcium movement in alpha₁-adrenoceptor mediated effects experiments were undertaken with nisoldipine and low extracellular calcium. To …
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Regulation of signal transduction by RGS4
… activity. The ability to inhibit intracellular calcium release by an activated 1b-adrenoceptor-G11 fusion protein was used in order to investigate the GAP activity of RGS4N88S, RGS4N128A and RGS4N88S,N128A. All three mutants had ablated GAP activity towards G11 and therefore failed to inhibit …
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Molecular mechanisms involved in cell response to mechanical forces
… cells were seeded could mainly cause global calcium responses of the cells. This global response was initiated by the influx of calcium across the stretch-activated channels in the plasma membrane. The subsequent production of inositol triphosphate (IP3) via phospholipase C (PLC) activation …
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Calciumkanaldichte in humanem ischämischen und reperfundierten, rechtsatrialen Myokardgewebe
Intracellular calcium overload is one of the major pathophysiological mechanisms contributing to myocardial ischemic injury. Two important calcium handling proteins responsible for the maintenance of an intracellular calcium homeostasis are the sarcolemmal voltage-gated L-type calcium channel …
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Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
<p>Calcium ions (Ca2+) are essential signaling molecules and must be carefully regulated to preserve specificity in function. One indispensible Ca2+ signaling protein is the ryanodine receptor (RyR) calcium release channel. RyR1 is essential for muscle contraction, and RyR1mutations can lead to …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… Several analogues potentiated intracellular calcium release by 5-HT in h5-HT2CR-CHO cells. Several compounds exhibited a favorable overall pharmacokinetic profile and modulated 5-HT2CRassociated behaviors (e.g., spontaneous motor activity and drug discrimination) in rats. Two predicted …
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Effects of Advancing Age on ER Calcium Regulation in Rat Superior Cervical Ganglia
<p>Intracellular calcium ([Ca<sup>2+</sup>]i) release from endoplasmic reticulum (ER) stores plays an important role in cell signaling. These stores are rapidly refilled via voltage-gated calcium channels or spontaneously via store-operated calcium channels and subsequent pumping by ER …
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Functions of Mediodorsal Thalamic Astrocytes in Cue-Based Learning
… synaptic transmission, with astrocytic calcium activity being linked to gliotransmitter release. Abnormalities in astrocytic calcium activity have been found to impair learning and memory, thus insights into their mechanism during cognitive processes in the MD could reveal novel targets …
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