Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Calcium mobilization"”.
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Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
… is well known that alterations in intracellular calcium, [Ca2]i, mobilization in the heart are among the major causes of cardiac dysfunction. To study the mechanism(s) involved in the development of diabetic cardio myopathy, [Ca2]i (determined by fluorescence microscopy and Ca-indicators) and …
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Pattern and Mechanism of Calcium Mobilization During Embryonic Development in a Viviparous Snake, <em>Virginia striatula</em>.
<p>Yolk supplies the majority of embryonic calcium in snakes. Oviparous and viviparous snakes also receive calcium late in development from the eggshell and placenta, respectively. The pattern and mechanism of calcium transport are partly understood for oviparous snakes. I studied a viviparous …
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
… to inhibit the increment of intracellular calcium level stimulated by endogenous ligand CCL5 was measured in the calcium mobilization assay as an indication of its CCR5 receptor antagonism. The anti-proliferation assay was performed to measure the ability of these new compounds to inhibit …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… IgE-mediated tyrosine phosphorylation of STAT5, calcium mobilization, and degranulation. GRK2 inhibitors (paroxetine and its analog CCG258747) inhibited FcεRI-induced calcium mobilization and degranulation, and their intravenous administration in mice resulted in substantial reduction of …
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Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… estrogenic protection and the correction of calcium imbalance caused by ryanodine receptor malfunction. The estrogen receptor is thought to elicit this estrogenic protection by acting as a nuclear transcription factor and increasing the expression of anti-apoptotic proteins. However, the …
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The characterization of major histocompatibility complex class II signal transduction pathways in antigen presenting cells
… This dissertation examines MHC-II-mediated calcium mobilization and demonstrates that it is an isotype-independent event, which leads to the dephosphorylation of NFAT. In addition, MHC-II molecules work in conjuction with the B cell receptor to increase NFAT activity. As opposed to calcium …
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Functional role of ZAP70 in Chronic Lymphocytic Leukaemia
… Here, I have shown that P505-15 reduces calcium mobilization, cell survival and proliferation in ZAP70 positive CLL cells. Knockdown of ZAP70 using siRNA in CLL patient cells was achieved, however efficiency varied between patients. Knockdown of ZAP70 using siRNA showed no significant …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… of the triterpenoids. The release of ATP and calcium mobilization from the cytosol, as platelets aggregate, was investigated using a commercial kit and Fura 2/AM respectively. The anti-acetylcholinesterase activity of the triterpenes was also investigated using a commercial kit. The compounds …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
… of signal transduction pathways that involve calcium mobilization, focal adhesion kinase (FAK) activation, and downstream events leading to alteration of cell function manifested by migration and matrix metal loproteinase (MMP) production. Our working model extends the previous three-step …
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The roles of human cytomegalovirus US27 gene product during virus infection
… In addition, US27 was shown to increase calcium mobilization of CXCR4 in response to its natural ligand CXCL12. cmvIL-10, an ortholog of human IL-10, was also found to enhance CXCR4 signaling and act synergistically with US27. In both HCMV-infected and US27-transfected cells, exposure to …
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Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation
… mediators following IgE-mediated activation. Calcium mobilization following mast cell activation is essential for degranulation and pro-inflammatory cytokine/chemokine production, processes that require the Ca2+/calmodulin (CaM)-dependent phosphatase, calcineurin. Neurogranin is a protein that …
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Glia-neuron signaling
… increase in the cytoplasmic level of glial free calcium. Perturbations which inhibited bradykinin-induced calcium mobilization prevented the release of EAAs from glia. The addition of ionomycin caused a calcium-dependent release of EAAs. Taken together, these data demonstrate that calcium is both …
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Group III mGluR8 negatively modulates TRP channels
… using RpCAMPS significantly reduced MO-induced calcium mobilization and there was a trend to reduce the number of MO-responsive cells. Taken together, these results show that group III mGluRs can negatively modulate TRPV1 and TRPA1 activity. Furthermore, it is likely that this modulation occurs …
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Effect of phosphorylcholine-based small molecule analogues of the immunomodulatory nematode product ES-62 on mast cell function
… disruption of key PLD-SPHK-dependent pathways of calcium, PKC and NF-кB activation. These data raised the possibility that ES-62 could be employed as an anti-allergy drug however it is a large molecule and hence immunogenic molecule and PC attachment is nematode-specific. Therefore, 65 small …
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Role of P2Y12 receptor-mediated ADP signalling at microglia in the phagocytosis of neurons
… of resting microglia. Additionally, fluorescent calcium response assays yielded significant decreases in acute calcium response to ADP in P2Y12-inhibited and knockdown cells, confirming that P2Y12 plays a major role in calcium mobilization due to ADP treatment in BV-2 microglia. Furthermore, …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… cancer cell lines. The data from both the calcium mobilization studies and the anti-proliferation studies suggests that the compounds synthesized have activity as CCR5 antagonists and as anti-proliferative agents in certain prostate cancer cell lines. In addition, a bivalent ligand …
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Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… B6.Sle1b and B6.129 reveal an altered pattern of calcium mobilization upon stimulation in T cells. In addition, CD4 T cells from B6.Sle1b demonstrate a reduction in IL-4 expression and secretion upon activation, suggesting that haplotype 2 of the Slam/CD2 family alters the immune response in T …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… caspase activity was shown to be independent of calcium mobilization though ions may play a part in other aspects of apoptosis. The use of additional apoptotic markers Annexin V and propidium iodide revealed no phosphatidylserine externalization and no direct electric field effects on membrane …
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Diverse Effects of Nanosecond Pulsed Electric Fields on Mammalian Cells
… investigated the effects of nsPEFs on induced calcium mobilization and changes in transmembrane potential in cultured cells. The results may further the development of nsPEFs as a basic investigative tool for discovery of new signaling pathways and stimulation of cell function. This application …
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