Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Calcium currents"”.
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Characterization Of High-Voltage-Activated Calcium Channels In Retinal Bipolar Cells
… I investigated the high-voltage-activated (HVA) calcium current in retinal bipolar cells in mice. In the first part of my dissertation, I characterized multiple bipolar cell-expressing GFP and/or Cre transgenic mouse lines. In the second part of my dissertation, by performing whole-cell …
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
… myocytes express two types of voltage operated calcium currents, a high voltage activated (HVA) L-type, and a low voltage activated (LVA) T-type. Influx of calcium into the cell through the L-type channel is responsible for excitation-contraction coupling in the heart. The T-type calcium current …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
Voltage-gated calcium channels contain a pore-forming alpha1 subunit and auxiliary alpha2delta, beta and gamma subunits. Of the three auxiliary subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium …
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Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus
… potentials thought to be mediated by both T-type calcium currents and calcium-activated nonselective cation currents (I<sub>CAN</sub>). However, the identity of I<sub>CAN</sub> and the possible contribution of thalamic circuits to slow rhythmic activity remain unclear. Using intracellular …
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A quantitative study of neuronal calcium signaling
… by transmembrane voltage changes, while calcium levels within the cell communicate information on a much slower time scale. Calcium acts as a second messenger responsible for modulating neuronal excitability in many ways including the mediation of gene transcription in the cell and the …
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Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
… glucose-associated alterations of voltage-gated calcium currents (VGCC) in small diameter dorsal root ganglion (DRG) neurons. Using behavioral, nerve-electrophysiology and patch-clamp methodology we examined the functional consequences of forced-exercise (treadmill, 5.4 km/week) on VGCC in …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in the heart is Cav3.1/α1G, and therefore we used Cav3.1/α1G transgenic (TG), knockout (-/-) and wild type mice respectively to define the role of …
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Calcium Channel Gamma(6) Subunits Are Unique Modulators of Low Voltage-Activated Calcium Current
The calcium channel gamma (gamma) subunit family consists of eight members whose functions include modulation of high voltage-activated (HVA) calcium currents in skeletal muscle and neurons, and regulation of AMPA receptor targeting. Cardiac myocytes express three gamma subunits, gamma 4, gamma6 …
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Investigation Into The Relationship Between Intestinal Slow Waves, Spike Bursts, and Motility
… and (ii) spike bursts which are believed to be calcium currents in the smooth muscle cells. The relationship between slow waves, spike bursts, and motility is of critical interest to the intestinal function, but is not clearly defined at the organ level. Recent high-resolution electrical mapping …
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Zur Drucksensitivität der Kanalfunktion vestibulärer Haarzellen Typ II
… activate a pressure-sensitive K+ current. These currents are inhibited by charybdotoxin, an inhibitor of Ca2+ dependent K+ channels. Furthermore cinnarizine is an inhibitor of voltage-gated Ca2+ currents in hair cells and is used as a drug in condition with vestibular vertigo. An aim of the …