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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 107 for “"Calcium channel"”.

  1. Calcium Channel Dysfunction in Huntington’s Disease

    Cherry, Sheree D.2016

    … functional properties of the voltage gated ion channels underlying the action potential and synaptic transmission. This study investigates the functional properties of high voltage activated (HVA) Ca<sup>2+</sup> channels in cortical neurons from HD transgenic mice and wild type littermates. Due …

    tenn-hsc Repository record

  2. Investigating calcium channel blockers as antimalarials

    Rajab, M2026

    … out at the University of Salford identified calcium channel blockers (CCBs) as potential antimalarial agents. A growing body of evidence has demonstrated the importance of calcium within the Plasmodium life cycle. Studies have shown CCBs and calmodulin inhibitors to exhibit antimalarial …

    salford Repository record

  3. Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans

    Saheki, Yasunori

    … membrane are sensed by presynaptic voltage-gated calcium channels that mediate calcium influx at the nerve terminals to execute exocytosis of various kinds of neurotransmitters. Defects in presynaptic calcium channels lead to many neurological disorders, emphasizing the importance of these …

    rockefeller Repository record

  4. Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure

    Riegle, Melissa AnnWake Forest University2014

    Alcohol is the third highest risk factor for health related problems in the world and leads to over two million deaths per year. Individuals abusing alcohol frequently cycle between drinking and withdrawal states, which among other adverse side effects can induce withdrawal seizures. Alcohol …

    wfu Repository record

  5. DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?

    Wang, FangTemple University. Libraries2012

    … study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in the heart is Cav3.1/α1G, and therefore we used Cav3.1/α1G transgenic (TG), knockout (-/-) and wild type mice respectively to define the role of …

    temple Repository record

  6. Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1

    Ozkan, Emin D.2010

    Calcium signaling is essential for all cellular processes. In brain these processes include basic synaptic transmission, modification of established synapses, elimination of synapses as well as elimination of whole neurons by way of apoptosis. In this thesis, we have studied two of these processes. …

    utswmed Repository record

  7. Development of blocking antibodies to the voltage-gated calcium channel cav3.2

    Kaleta, MartaLondon Metropolitan University2018

    T-type voltage-dependent calcium channel Cav3.2 is a four-domain channel participating in various physiological and pathological processes principally in the nervous system but also in non-excitable cells. Upregulation of Cav3.2 or mutations in this channel are found in pain syndromes, certain …

    london-metro Repository record

  8. Regulation od the N-Type calcium channel gene by C/EBP

    김, 민지2011

    Master

    ajou Repository record

  9. Expression and Characterization of Calcium Channel Alpha1 Subunits in Atrial Tissue

    Mitchell, Jennifer WiedenmanUniversity of Illinois at Urbana-Champaign2015

    … tissue expresses two types of voltage-activated calcium current, a high voltage-activated (HVA) L-type and a low-voltage activated (LVA) T-type. The LVA calcium current is often associated with growth and nuclear division. In atrial tissue, the LVA calcium current demonstrates developmental …

    uiuc Repository record

  10. MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE

    LIN QINGSHU2015

    Voltage-gated calcium channels play a vital role in triggering the vesicle release in presynaptic terminals. We have identified several molecules in modulating the calcium channel functions. One of our focus is snapin from presynaptic complex, and the other is gangliosides and anti-gangliosides …

    nus Repository record

  11. Lead Activation of a Developmentally Regulated Calcium Channel in Rat Hippocampal Nerve Terminals

    Rhodes, Troy E.2019

    … deficits in learning and memory by altering calcium (Ca<sup>2+</sup>) dependent processes. Isolated presynaptic nerve terminals from rat hippocampus were loaded with the intracellular (Ca<sup>2+</sup>) indicator Fura-2. The changes in cytoplasmic free calcium ([Ca<sup>2+</sup>]<sub>i</sub>) …

    odu Repository record

  12. Molecular Interactions and Physiological Function of the Voltage-Dependent Calcium Channel Gamma6 Subunit

    Garcia, ThomasUniversity of Illinois at Urbana-Champaign2015

    … I, I give an overview of the Voltage-dependent Calcium Channel (VDCC) and its importance as a key regulator of intracellular calcium. I attempt to provide a thorough explanation of the nomenclature system used to describe the various VDCC subunits, and discuss the structure and interaction of …

    uiuc Repository record

  13. The effect of calcium channel blocking agents on cold induced cerebral edema in mice

    Bloss, Mary Joan1983

    This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

    iupui Repository record

  14. Calcium Channel Gamma(6) Subunits Are Unique Modulators of Low Voltage-Activated Calcium Current

    Hansen, Jared PaulUniversity of Illinois at Urbana-Champaign2015

    The calcium channel gamma (gamma) subunit family consists of eight members whose functions include modulation of high voltage-activated (HVA) calcium currents in skeletal muscle and neurons, and regulation of AMPA receptor targeting. Cardiac myocytes express three gamma subunits, gamma 4, gamma6 …

    uiuc Repository record

  15. Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action

    Chen, Ren-ShiangUniversity of Illinois at Urbana-Champaign2015

    Voltage-gated calcium channels contain a pore-forming alpha1 subunit and auxiliary alpha2delta, beta and gamma subunits. Of the three auxiliary subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium …

    uiuc Repository record

  16. Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle

    Chaplin, Nathan L., author, Amberg, Gregory, advisor, DeLuca, Jennifer, committee member, Tamkun, Michael, committee member, Tsunoda, Susan, committee memberColorado State University. Libraries2015

    … which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of calcium influx in these cells occurs through a small number of persistently active channels, whose activity increases with …

    colostate Repository record

  17. Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection

    Egunlusi, Ayodeji OlatundeUniversity of the Western Cape2014

    … using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction between p-benzoquinone and monomerised dicyclopentadiene yielded tricycloundeca- 4,9-diene-3,6-dione which was used as the …

    western-cape Repository record

  18. Gating alterations inducing neuropsychiatric disorders associated with Cav1.2 and Cav1.3 L-type calcium channel mutations

    Carbone, Emilio, Guarina, LauraUniversità degli Studi di Torino2019

    unito Repository record

  19. Novel antiepileptic drug, gabapentin (Neurontin), binds to the [alpha]?[delta] subunit of a voltage-dependent calcium channel.

    Brown, Jason Peter.University of Cambridge1996

    cambridge

  20. Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit

    TANG ZHENZHI2006

    L-type (CaV1.2) voltage-gated calcium channels play critical roles in membrane excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 …

    nus Repository record

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