Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Calcium Signaling"”.
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Ryanodine receptors in calcium signaling pathways
<p>Calcium (Ca<sup>2+</sup>) plays an important role as a second messenger, transmitting the message of arrival of stimuli such as hormones and neurotransmitters to the intracellular system that carries out the cellular response to the stimulus. The universality of Ca<sup>2+</sup> as an …
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A quantitative study of neuronal calcium signaling
Neurons have both a fast and slow mode of signaling. Fast signals are communicated by transmembrane voltage changes, while calcium levels within the cell communicate information on a much slower time scale. Calcium acts as a second messenger responsible for modulating neuronal excitability in many …
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Spontaneous Neurotransmission as a Driver of Calcium Signaling
… by spontaneous release are able to drive large calcium transients that maintain synaptic homeostasis and suppress local protein synthesis.
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The role of Ryanodine receptors in neuronal calcium signaling
<p>Calcium (Ca<sup>2+</sup>) is a universal second messenger controlling a wide variety of cellular reactions and adaptive responses. All the versatility of a Ca<sup>2+</sup> signaling requires that the concentration of Ca<sup>2+</sup> ions in the cytoplasm be highly regulated. Generation of …
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Regulation of nitrate uptake and calcium signaling in arabidopsis
… through the use of fluorescence imaging. The calcium responses to NO3- as a signal were captured for the two uptake kinetic systems, high-affinity transporter system (HATS) and low-affinity transporter system (LATS). A unique calcium signature was identified in root epidermal cells and root …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… factors downstream of calcineurin and other calcium-regulated signaling pathways in the control of myofiber specialization. By analyzing two fiber type-specific enhancers, I was able to demonstrate that there are functional NFAT (nuclear factor of activated T cells) and MEF2 (myocyte-specific …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… expressed endoplasmic-reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influence many signaling pathways including those regulating apoptosis. IP3R activity is regulated by protein-protein interactions, including binding to proto-oncogenes and tumor suppressors to …
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Calcium Signaling Dynamics in RBL Cells Under Pulsed Ligand Exposure
Understanding cellular signaling is important to learning about life at a fundamental level. As an extension of this, understanding the dysregulation of cell signaling is the key to identifying and treating disease. At present, there are multitudes of ways to investigate the cell signaling process, …
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Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset familial Alzheimer disease (AD), presenilin 1 and presenilin 2. Several studies …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… Protein 3 (EB3) in regulating pathological calcium signaling and endothelial barrier integrity during acute lung injury. I hypothesized that EB3-mediated pathological calcium signaling promotes endothelial dysfunction and impairs vascular repair, and that pharmacological inhibition of EB3 …
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Crosstalk Between Calcium Signaling and Lipid Metabolism at Endoplasmic Reticulum-Plasma Membrane Junctions
Receptor-induced Ca2+ signaling is the key to many cellular functions, such as secretion, migration, differentiation, and proliferation. The increase in cytosolic Ca2+ signals is dependent on the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane (PM). To enable …
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Altered smooth muscle intracellular calcium signaling mechanisms in metabolic syndrome induced coronary artery disease
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… estrogenic protection and the correction of calcium imbalance caused by ryanodine receptor malfunction. The estrogen receptor is thought to elicit this estrogenic protection by acting as a nuclear transcription factor and increasing the expression of anti-apoptotic proteins. However, the …
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Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area
… glutamate receptor (mGluR)-dependent calcium (Ca²⁺) signaling via an increase in inositol 1,4,5-trisphosphate(IP3) sensitivity. Isolation-mediated effects on Ca²⁺ signaling and NMDAR plasticity were not reversed by a subsequent period of resocialization. Furthermore, social isolation …
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Role of Trp Channels In Mediating The Calcium Signaling Response of Brain Endothelial Cells to Mechanical Stretch
… nervous system homeostasis. Recently cytosolic calcium levels ([Ca<sup>2+</sup>]i), observed to elevate following TBI, have been shown to influence endothelial barrier integrity. However, the mechanism by which TBI-induced calcium signaling alters the endothelial barrier remains unknown. In the …
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Modeling physiological calcium signaling for fast transmitter release at a central synapse : topography of release sites and its functional significance
This thesis addresses how calcium channels and neurotransmitter vesicles at release sites are spatially organized to control fast synaptic transmission in the central nervous system (topography of release sites). The problem, investigated here for the giant synapse calyx of Held, has been addressed …
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Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2
… tyrosine kinase 2 in pressure/stretch-induced signaling mechanisms in the vascular wall. Using two different knockout mouse models, we uncovered a novel role of microRNAs in the pressure-induced myogenic response. We demonstrated that global deletion of smooth muscle-specific microRNAs causes a …
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Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1
Calcium signaling is essential for all cellular processes. In brain these processes include basic synaptic transmission, modification of established synapses, elimination of synapses as well as elimination of whole neurons by way of apoptosis. In this thesis, we have studied two of these processes. …
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The Role of Piezo1 in Mediating Chondrocyte Cell Signaling and Senescence
… have been implicated in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout (cKO) in modulating calcium signaling and senescence in OA, particularly under the supra-physiologic inflammatory condition of a high-fat diet …
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