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Showing 1 to 20 of 44 for “"Calcium Oxalate"”.
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Crystallization of calcium oxalate on molecularly imprinted polymer surfaces
Calcium oxalate (CaOx) is the most common component of human kidney stones. Heterogeneous nucleation is regarded as the key mechanism in this process. As such, crystallization of this substance has been studied in several different model systems. However, molecular imprinting has not been …
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Inhibition of Calcium Oxalate Monohydrate Crystallization Using Organic Growth Modifiers
Inhibition of calcium oxalate monohydrate (COM), the most common component in human kidney stone diseases, was investigated using various structural derivatives of citrate, a known inhibitor of COM crystallization. Bulk crystallization studies revealed the specific binding of modifiers to COM …
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A study of the growth and aggregation of calcium oxalate monohydrate / by Allan Sidney Bramley.
… investigation of the growth and aggregation of calcium oxalate mono-dydrate in metastable saline solutions using batch and continuous systems. The physical chemistry of calcium oxalate mono-hydrate in aqueous solutions is considered. A tubular crystalliser to be used as an in vitro system is …
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The effect of Ascorbic acid ingestion on the risk of calcium oxalate kidney stone formation
… ingestion of ascorbic acid on the risk of calcium oxalate kidney stone formation. Ten healthy male subjects (ages 20 to 30 years) participated in the study. Each was required to ingest a daily dose of 4 g ascorbic acid per day for a period of 5 days. Twenty-four hour urines were collected …
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The effect of mTOR inhibitor rapamycin on a dietary Drosophila melanogaster model of calcium oxalate nephrolithiasis
… nephrolithiasis, 24-hour urinary excretion of oxalate, sodium, uric acid, calcium, and phosphorous as well as lower pH. Calcium oxalate crystals produce ROS in renal epithelial cells and upregulate ROS and also mTOR activity. Rapamycin pharmacologically inhibits mTOR leading to autophagy – a …
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Measurement of Pre and Postprandial Urine Calcium to Creatinine Ratio to Identify Calcium Oxalate Urolithiasis in Miniature Schnauzers
… test to detect abnormal calciuresis and predict calcium oxalate (CaOx) urolith presence in Miniature Schnauzers. We investigated the impact of postprandial time on the specificity of urine calcium:creatine (UCa/Cr) in identifying affected dogs. The hypotheses were: 1) Significant differences …
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The effects of calcium, magnesium and citrate health supplements on urinary risk factors for calcium oxalate kidney stone formation
… of various health supplements on the risk of calcium oxalate (CaOx) kidney stone formation. Four separate studies comprised the entire project. In the first study, a new approach was implemented to investigate the individual, additive and synergistic effects of calcium, magnesium and citrate …
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The use of ¹H-NMR analysis of urine to discriminate between calcium oxalate kidney stone patients and healthy controls
NMR has been used to study the metabolites found in body fluids, like urine, in the past three decades. It has more recently been used to study a lare range of diseases and the toxicolgoical effect of drugs on animals, by looking at metabolite patterns in the urine. The major advanteges of using …
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The effects of calcium, magnesium and citrate health supplements on urinary risk factors for calcium oxalate kidney stone formation
… of various health supplements on the risk of calcium oxalate (CaOx) kidney stone formation. Four separate studies comprised the entire project. In the first study, a new approach was implemented to investigate the individual, additive and synergistic effects of calcium, magnesium and citrate …
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The design, development and testing of a non-invasive continuous crystalliser system for the study of calcium oxalate crystallisation processes
… were performed to investigate the effect on calcium oxalate crystallisation of varying the concentration of sodium oxalate solutions used to initiate crystallisation, and also to investigate the effect of varying the temperature. A further series of experiments was performed to determine the …
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Urinary prothrombin fragment 1 : a potential role-player in the protection of South African blacks from calcium oxalate kidney stone disease
… in the black group. UPTFI was isolated from calcium oxalate (CaOx) crystals and purified by reverse phase (RP)-high performance liquid chromatography (HPLC) from the urine of healthy white (WFl) and black (BFl) subjects. The identity of the purified proteins was confirmed by Western blotting, …
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Investigation of the in vitro and in vivo effects of some herbal preparations on risk factors for calcium oxalate kidney stone disease
… tested on the crystallization characteristics of calcium oxalate (CaOx), the predominant stone-forming salt in urine. These investigations were performed in synthetic urine and real urine collected from healthy black and white South African males and the following parameters were assessed: urine …
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The effect of inositol-hexakisphosphate (phytate) on urinary risk factors for calcium oxalate urolithiasis in South African population groups with different kidney stone risk profiles : theoretical modelling, in vitro crystallisation experiments and in vivo human studies
… of this thesis were to establish whether soluble calcium-phytate complexes inhibit calcium oxalate crystallisation and whether a higher dietary intake of phytate in South African black subjects compared to white subjects may contribute to the relative rarity of urolithiasis in this group. …
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Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects
… aspects of this phenomenon. Carbohydrate and oxalate-containing dietary agents were identified as being of interest since surveys have paradoxically demonstrated that the consumption of these potentially lithogenic substances is significantly higher in the black group. The carbohydrates …
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Investigation of the effect of hydroxycitric acid on urinary calcium oxalate risk factors for kidney stone formation in artificial urine: theoretical modelling and in vitro crystallisation experiments
… stones are composed of different mineral types. Calcium Oxalate is the most common kind of stone. The principal aim of this research was to establish whether hydroxycitrate (HCA) affects and/or inhibits calcium oxalate crystallisation. A three-pronged approach was adopted, involving the …
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Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation
Approximately 12 % of males in the Western world are likely to suffer at least one kidney stone in their life. The incidence of kidney stone disease in South Africa is similar in white males; however stone occurrence in the South African black population is extremely rare. The difference between …
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Investigation of the role of dietary myo-inositol hexakisphosphate (phytate) on the relative risk of calcium oxalate kidney stone formation in black and white male South African subjects
Previous studies have shown that caJclum oxalate (CaOx) stone-formers have lower urinary concentrations of myo-inositol hexakisphosphate (phytate or IPe) than healthy individuals, that dietary intake of this substance leads to its increased urinary excretion and that it is an inhibitor of CaOx …
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Defining the role of 4-hydroxy-2-oxoglutarate aldolase in hydroxyproline metabolism and primary hyperoxaluria
… (GR), respectively. The resulting increase in oxalate excretion can lead to the formation of calcium oxalate kidney stones, renal calcium oxalate deposition, and in extreme cases renal failure. Recent evidence has shown that the degradation of 4-hydroxyproline (Hyp), generated from endogenous …
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Kidney stone rarity in South Africa's black population : investigation of the biochemical and physico-chemical properties of Tamm Horsfall Mucoprotein as a possible contributory factor
… mucoprotein (THP) is a powerful inhibitor of calcium oxalate crystallisation. Since urolithiasis in South African blacks is extremely rare, this study was undertaken to compare the relative inhibitory and biochemical properties of this protein in South African black and white healthy and …
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