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Showing 1 to 20 of 70 for “"Calcineurin"”.
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Studies on bovine eye retinal calcineurin
Calcineurin (CaN), a member of ser/thr protein phosphatase, was cloned from bovine retina. The peptide sequence of CaN A subunit is consisted of 511 amino acid residues. A 10 amino acid (A-T-V-E-A-I-E-A-D-E-A) deletion before the autoinhibitory domain was observed in bovine retina CaN A compared to …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… hypertrophy relies on activation of the calcineurin-NFAT pathway, and inhibition of calcineurin is sufficient to block growth in response to isoproterenol. I also observed that FHL2 is up-regulated in mouse hearts after isoproterenol treatment. Based on this, we hypothesized that FHL2 …
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Untersuchung einer Calcineurin-bindungsdefizienten FKBP12.6-Mutante in Kardiomyozyten
… bekannt, dass FKBP12.6 die Proteinphosphatase Calcineurin bindet und FK506-abhängig inhibiert. In dieser Arbeit wurde erstmals eine Calcineurin-bindungsdefiziente Mutante (FKBP12.6G89PV90K )erzeugt, um die funktionelle Bedeutung der FKBP12.6-Calcineurin-Interaktion zu untersuchen. Es konnte …
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The role of Calcineurin in skeletal muscle differentiation
1. Strong evidence suggests that Calcineurin levels are higher in fast muscle fibers compared to slow-twitch in resting skeletal muscles. Activation of the Calcineurin in 4 skeletal muscle myocytes selectively up-regulates slowfiber- specific gene promoters through a mechanism involving the …
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Modulatoren des Calcineurin-NFATc-Signalweges in humanen TH-Zellen
… Serin/Threonin-Phosphatase Calcineurin ist ein Schlüsselmolekül des T-Zell-Rezeptorabhängigen Signalnetzwerkes. Calcineurin aktiviert die Transkriptionsfaktoren der NFATc-Familie durch Dephosphorylierung und reguliert darüber die Expression wichtiger Zytokine und …
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Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
… examines one such calcium-stimulated enzyme, calcineurin, in the context of two common neurological pathologies, status epilepticus and traumatic brain injury.Status epilepticus was induced by pilocarpine injection. NMDA-dependent increases in calcineurin activity were observed in cortical and …
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Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… of the calcium-regulated protein phosphatase, calcineurin. In this current study, we have now extended these findings to identify the IL-11 cytokine and the Nurr1 orphan nuclear hormone receptor as functionally important downstream transcriptional targets of the PGF2α/calcineurin-pathway …
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The calcineurin inhibitor cyclosporine A activates the renal Na-(K)-Cl cotransporters via local and systemic mechanisms
The two calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus are potent immunosuppressive drugs that have become indispensable in the post-transplantational therapy and in the treatment of autoimmune diseases. Immunosuppression via CNIs is achieved by inhibition of the calcineurin …
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Bedeutung der Interaktion von Calcineurin und SORLA für die Regulation des Na⁺,K⁺,2Cl⁻-Kotransporters (NKCC2) in der Niere
… war die ebenfalls im TAL exprimierte Phosphatase Calcineurin Aβ (CnAβ) per Western blot um das zweifache gesteigert. Parallel hierzu wurde immunhistochemisch die Kolokalisation von verstärktem CnAβ-Signal und NKCC2 bestätigt. Beide Befunde geben zusammen den Hinweis auf einen Bezug zwischen der …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… Previous studies have demonstrated that calcineurin activity is required to maintain slow myofiber identity. I am interested in determining the transcription factors downstream of calcineurin and other calcium-regulated signaling pathways in the control of myofiber specialization. By …
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Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis
… 1/2 (Erk1/2) and of particular interest the calcineurin/nuclear factor of activated T-cell (NFAT) pathway. Inhibition of calcineurin activity by the drug cyclopsorin A (CsA) has been shown to inhibit processes required for successful angiogenesis such as in vitro cell migration, tube …
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PMCA as a regulator of calcium/calmodulin-dependent signal transduction pathways
… of transcription factors by its interaction with calcineurin A in mammalian cells when ectopically expressed. This prompted the investigation into other isoforms of PMCA that may interact with the calcium/calmodulin-dependent calcineurin, to determine if this interaction was isoform-specific in a …
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Gene regulation and hypertroipc responses in age-matched control and STZ-treated rats
Calcineurin is an endogenous calcium dependent protein which is involved in the development of cardiac hypertrophy. This study investigated the role of calcineurin in the streptozotocin (STZ)- induced rat heart compared to their age-matched healthy control hearts. The calcineurin signal process is …
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Signal transduction pathways involved in skeletal muscle fibre type regulation
… and NADH-TR staining, following blockade of the calcineurin signalling pathway. Metabolic enzyme assays and northern blots were employed to assess the changes in enzyme activities and MEC isoform expression levels following blockade of the calcineurin and ERKI/2 signalling pathways in primary …
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Einfluss der Immunsuppressiva Cyclosporin A und Everolimus auf die funktionelle DNA-Reparaturfähigkeit sowie auf die Regulation von DNA-Reparatur-Genen
… eine Hemmung der Calcium-abhängigen Phosphatase Calcineurin und über Calcineurin-abhängige Signalwege (z. B. CREB, NFAT), vermittelt wird. Es zeigte sich, dass Calcium die NER ansteigen lässt. Darüber hinaus konnte auch eine Calcineurin-Überexpression die NER erhöhen sowie die Cyclosporin …
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A NOVEL SELECTIVE INHIBITOR FOR PLASMA MEMBRANE CALCIUM ATPase 4 IMPROVES VEGF-MEDIATED ANGIOGENESIS
… a major problem. VEGF-mediated activation of the calcineurin/NFAT signalling pathway has been identified as a crucial regulator of angiogenesis. Our laboratory has recently shown a novel role for the plasma membrane calcium ATPase 4 (PMCA4) protein as a negative regulator of VEGF-induced …
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The roles of Cabin1 and Left1 in T cell development
Cabinl binds calcineurin and myocyte enhancer factor 2 (MEF2) through the C-terminal region. In cell lines, these interactions inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 by MEF2. The role of these interactions in vivo was investigated using a mutant …
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The Influence of Insulin-like Growth Factor Pathway Gene Polymorphisms on the Strength Training Response of Muscle Phenotypes in Older Adults
… addition, there have been reports that IGF-1 and calcineurin are linked in a common pathway to induce skeletal muscle cell hypertrophy. A previous study has shown that an insertion/deletion (I/D) polymorphism in the gene encoding the regulatory subunit of calcineurin, calcineurin B, influences …
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Skeletal muscle adaptations in cachectic, tumor-bearing rats
… Ca2+/calmodulin-dependent protein phosphatase, calcineurin, has been suggested as a critical factor regulating skeletal muscle growth and fiber-type dependent gene expression (Chin, 1998; Wu, 2000; Olson, 2000; Otis, 2001). The protein content of the catalytic subunit (CaNa) and the regulatory …
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