Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cajal bodies"”.
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Biochemische und zellbiologische Untersuchungen zur Rolle der Cajal Bodies bei der Zusammenlagerung spleißosomaler UsnRNP Partikel
… die Spleißfaktorkompartimente (Speckles) und die Cajal Bodies diskutiert. Während die Speckles sehr wahrscheinlich als Lagerstätten dienen, von denen aus Spleißfaktoren zu Orten mit hoher Transkriptionsaktivität rekrutiert werden, gab es bereits Hinweise darauf, dass die Cajal Bodies eine Rolle …
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Discrete elements of the U2 snRNP regulate its intranuclear trafficking and recruitment to nascent transcripts
… site is sufficient for U2 snRNP association with Cajal bodies after nuclear entry. For SL4, I further show that the associated protein U2B” rather than SL4 itself provides the targeting activity, which establishes a critical new role for U2B” in the pre-mRNA splicing pathway. Additionally, I …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
… displacements of coilin and SMN proteins in Cajal bodies and direct dissociation of coilin-SMN associated complexes. Fluorescence resonance energy transfer changes of coilin-SMN depend on force magnitude, an intact F-actin, cytoskeletal tension, Lamin A/C, or substrate rigidity. Other protein …
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A Cell Biological Determination of Integrator Subunit Localization
… of discrete subnuclear localization (i.e. to Cajal bodies) of any of the subunits could provide important clues to the function of that subunit. In this study, we used a cell biological approach to determine the localization of the 14 Integrator subunits. <strong>We hypothesized that the …
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Human FRG1 is an Actin-Bundling and a RNA-Associated Protein with Distinct Subcellular Localizations
… of the endogenous FRG1 is localized in nucleoli, Cajal bodies, and actively transcribed chromatin associated with nascent RNA transcripts, supporting a function in RNA biogenesis. Furthermore, we show that FRG1 interacts specifically with RNA in vitro, associates with mRNA in vivo, and directly …
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The Apollo Nuclease Binds To TRF2 and Protects
… interacts directly with Apollo and localizes to Cajal bodies, the translesion synthesis polymerase polη, and the homolgous recombination factor Rad51. The association of these proteins with Apollo suggests potential roles for Apollo in telomerase recruitment and formation of the protective t-loop …
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Phase Transitions of Multivalent Adaptor Proteins
… discovery of nuages, other structures such as Cajal bodies, the nucleolus, promyelocytic leukemia (PML) bodies, paraspeckles, etc., were also described as membraneless organelles. Furthermore, membranes themselves are self-assembled entities of lipids, proteins and carbohydrates. Additionally, …