Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"CagA"”.
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Motivos EPIYA en la proteína CagA en aislamientos colombianos de Helicobacter pyliri provenientes de la ciudad de Bogotá
… fuertemente con el factor de virulencia CagA, una proteína que presenta sitios de fosforilación EPIYA que están relacionados con la capacidad oncogénica de la proteína. El objetivo de este estudio fue determinar los motivos EPIYA presentes en la proteína CagA en aislamientos de …
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Prevalencia de los genotipos de virulencia de Helicobacter pylori cagA, vacA, babA2 e iceA en pacientes colombianos con dispepsia funcional
… que se consideran más agresivos, tales como cagA, vacA, babA2 e iceA y se determinaron mediante PCR alelo específica en 119 aislamientos de pacientes con dispepsia funcional. Adicionalmente se determinó el genotipo más frecuente en los aislamientos de pacientes con antecedentes familiares de …
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Regulation of RUNX3 in gastric and breast cancer
… cancer and breast cancer. Chronic infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric adenocarcinoma. The cagA gene product CagA is injected into gastric epithelial cells and disturbs cellular functions by physically interacting with and …
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Helicobacter pylori and its Association with Gastric and Oesophageal Carcinomas
… Helicoblot 2.1. The more virulent H. pylori cagA-positive strain was identified by the CagA band in Helicoblot 2.1. We found that H. pylori seropositivity was associated with a higher risk of non-cardia gastric adenocarcinoma. H. pylori seropositivity was a risk factor for non-cardia gastric …
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New insights into a complex host-pathogen interaction: mechanisms of Helicobacter pylori activation of NF-κB
… NF-κB activation. The H. pylori virulence factor CagA, encoded by the cagPAI, is injected into host cells via a type 4 secretion system, where it interacts with a number of different signaling pathways leading to inflammation and cell scattering. While a number of these interactions have been …
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A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell
… island (cag PAl) that encodes and secretes the CagA protein into host epithelial cells via a type IV secretion system. To date, CagA is the only identified effector protein of the cag PAI. The goal of this study was to identify novel H pylori virulence factors, to further elucidate their role in …
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Unterschiede in der TGF-[beta]-vermittelten Signaltransduktion in aktivierten hepatischen Sternzellen unterhalb der Smad2-Phosphorylierung
… lead to upregulation of PAI-1, Smad7 and (CAGA)9-MLP-Luc subsequent to Smad2 phosphorylation. Two further TGF-beta responsive genes, TIMP-1 and type I collagen were not affected. In contrast to primary cultured HSC, which were inhibited in their growth, TGF-beta1 did not influence the …
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Multiple virulence genes and other MRNA regulatory targets are differentially expressed in two Helicobacter pylori strains overexpressing small RNAs
… secretion system and its associated cytotoxin, CagA. Although the genetic regulation necessary for these and other virulence traits is complicated by a relative lack of regulatory proteins in H. pylori, its wealth of small RNAs (sRNAs) may also regulate mRNAs, including in the cagPAI. The …
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The transcriptional control of virulence gene expression in Helicobacter pylori
… and finally the cytotoxin associated antigen CagA is analysed as representative of the cag pathogenicity island, which is supposed to account for the phenomena of chronic inflammation and tissue damage observed in the later phases of infection. RNA analyses and in vitro transcription …
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Einfluss von BMP-7 und Endoglin auf den TGF-beta Signalweg bei fibrosierenden Lebererkrankungen
… does antagonize the Collagen I expression and (CAGA)12-MLP-Luc activity which are stimulated by TGF-b1. These effects are negotiated using the ALK5/Smad3 pathway. Furthermore, it could be shown that over expression of endoglin in these cells leads on the one hand to an inhibition of the …
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Helicobacter pylori Type 4 Secretion System Modulates Host T Cell Responses
… (T4SS) translocated components: effector protein CagA and cell-wall peptidoglycan (PG) fragments for up-regulating B7-H1 as well as B7-H3, and for down-regulating B7-H2 on GEC. These data were validated in vivo by using a mouse model of infection. My study demonstrated that, along with T4SS, …
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Lösliches Endoglin (sCD105) : diagnostische Wertigkeit bei chronischen Lebererkrankungen und funktionelle Bedeutung für die Signaltransduction von transforming growth factor (TGF-beta)
… for the detection of phosphorylated Smad3, i.e. (CAGA)12-MLP Luc. For the evaluation of sCD105 as a marker for the occurence of HCC in high-risk patients, we measured the concentration of sCD105 in both, 121 patients of chronic liver disease visited Aachen university hospital during one year and …
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Characterization of Helicobacter pylori sRNAs HPnc2525, HPnc2600, and HPnc2645
… a type IV secretion system that transports the CagA effector into host gastric epithelial cells. Regulation of the cagPAI is a vital area of research. Previous studies on H. pylori and other bacteria have found that small RNAs (sRNAs) play a role in gene regulation. These transcripts are 50-300 …
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NATURAL SOURCES OF ELLAGITANNINS TO COUNTERACT H. PYLORI INFECTION
… di due diversi ceppi di H. pylori, uno cagA-positivo (utilizzando il ceppo 26695) e un ceppo clinico cagA-negativo, e sono poi stati studiati l'espressione di diversi geni pro- infiammatori, il rilascio dei principali mediatori infiammatori (tra cui, IL-8 e IL-6) e il coinvolgimento del …
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Cloning and sequence analysis of plasmid DNA from Helicobactor pylori
… stretch of near identity to the chromosomal cagA gene (cytotoxin associated gene) was detected. The results also indicated that the ORF1 encoded protein was homologous to replication proteins found in nine other plasmids isolated from various organisms, including Campylobacter, Pediococcus, …
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Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis
… with increased gastric cancer risk, such as CagA and the s1/m1 VacA genotype. We also identified the adhesin BabA to have a South American variant with a specific selection pressure on the BabA protein in this region. This could have effects on the adhesion properties and consequently, strain …
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Untersuchungen zur TGF-[beta]1-Expression und -Bioverfügbarkeit bei der Leberfibrogenese
… copies of a TGF-Beta 1-inducible DNA element (“CAGA”), confirmed responsiveness of the cells to active TGF-Beta 1 and indicate basely synthesized TGF-Beta 1 being secreted as inactive complex which can be activated by transient acidification. Our data show that LTBP-1 and TGF-Beta 1 are …
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Charakterisierung der Helicobacter pylori-assoziierten Magenadenokarzinogenese am Tiermodell des Mongolischen Gerbils: Rolle der cag-Pathogenitätsinsel bei der Induktion präkanzeröser Prozesse.
… H. pylori-Stämme (Typ I) das Effektorprotein CagA in die Wirtszelle zu translozieren, wird vermutlich eine Signaltransduktionskaskade gestartet, die auf die Physiologie und Architektur der Magenmukosa direkt regulatorisch wirkt. Ein Ziel dieser Arbeit war es, den Regulationsmechanismus der H. …
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Assessing the preparedness of the schooling system for The Fourth Industrial Revolution: The case study of two secondary schools in the Ekurhuleni South Education District
… support technology-integrated teaching (Skhephe, Caga and Boadzo, 2020). Furthermore, access to technology for education seems to be limited and unequal across the nine provinces and different school quintiles (Meyer and Gent, 2016 in Kayembe and Nel, 2019). Despite this, the World Economic Forum …
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An assessment of gastric cancer associated factors and strategies for early case detection in patients seen at the university teaching hospital in Lusaka, Zambia.
… or GP (OR 1.9; 95% CI 0.4-17.6). Antibodies to CagA (p=0.0007), VacA (p=0.0006), HcpC (p=0.0006) and Omp (p=0.03) were significantly higher in active gastric inflammation than in GA. Overall, there was no association between H. bilis or H. hepaticus seropositivity and GA or GP. Serological …
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