Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Caenorhabditis elegans--Genetics"”.
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Combining microbial functional metagenomics and Caenorhabditis elegans genetics to uncover and characterise novel bioactive compounds
… of inhibitors that target the nematode Caenorhabditis elegans. Environmental DNA from marine habitats was expressed in Escherichia coli and the resulting functional (meta) genomic libraries were screened by selective grazing of the nematode C. elegans, in a simple, rapid, high-throughput …
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Temporal control of vulval precursor cell fate patterning in Caenorhabditis elegans
… events occur at the correct time and place. C. elegans vulval development offers a convenient experimental system for investigating the temporal and spatial regulation of multiple developmental decisions in response to different patterning signals. In this thesis, I present my studies on the …
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Understanding Chemotaxis in the Nematode Caenorhabditis elegans: From Molecules to Behavior
… behavior--chemotaxis--in the nematode worm Caenorhabditis elegans. My work focuses on a pair of amphid sensory neurons at the head end of the worm called ASEs. The neurons are exposed and respond to environmental chemical signals, and instruct downstream locomotory responses that cause the …
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Microtubules, Acetylation, and MEC-3 Regulated Genes in C. Elegans Mechanosensations
… self-awareness. The small soil dwelling nematode Caenorhabditis elegans has proven to be a useful system in which to study neuronal mechanosensation and the development of specialized neuronal subtypes. Response to gentle body touch in C. elegans is mediated by the six Touch Receptor Neurons …
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Inferring Transcriptional and Post-Transcriptional Network Structure by Exploiting Natural Sequence Variation
… cerevisiae (baker’s yeast) as well as Caenorhabditis elegans (roundworm). The first study focused on inferring the in vitro binding specificity of RNA-binding proteins (RBPs). We first analyzed a recent compendium of in vivo mRNA binding data to model the sequence specificity of 45 …
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A genetic interaction network of constitutive heterochromatin in Caenorhabditis elegans
… components of constitutive heterochromatin in *Caenorhabditis elegans* through conducting a set of genetic interaction screens. I began by designing a high throughput screening approach using RNAi to find genetic enhancers and suppressors of the growth and fertility defects of …