Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Caenorhabditis elegans Proteins"”.
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The balance of poly(U) polymerase activity ensures germline identity, survival, and development in Caenorhabditis elegans
… Here, we investigated the roles of three Caenorhabditis elegans proteins, with in vitro PUP activity, in germline development. PUP-1/CDE-1 and PUP-2 are known to target certain classes of small non-coding RNA, and the function of PUP-3 remains unknown. We examined the developmental …
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C. Elegans OMA-1 and OMA-2 are Transcriptional and Translational Repressors of Germline Fate
… are needed for adult reproduction. During C. elegans germline development global transcription is repressed in specialized, mature diakinetic oocytes of the adult animal and transcription is reactivated as zygotic transcription in the 4-cell stage embryo but only in somatic blastomeres. Global …
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Identification of Ligands for the Orphan Nuclear Receptor DAF-12 That Govern Dauer Formation and Reproduction in C. Elegans
… in the physiology of free-living nematode, C. elegans. DAF-12 is best known for its role in regulating dauer formation, a non-reproductive larval state entered in harsh environments and marked by developmental arrest, stress resistance, and extended life-span. Genetic screens for genes …
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Identification and Characterization of EFL-3, a C. Elegans E2F Transcription Factor
… through the cooperative efforts of Hox and E2F proteins. E2F transcription factors are critical, conserved regulators of the cell cycle and apoptosis. However, little is known about the two most recently discovered mammalian E2Fs—-E2F7 and E2F8. In the nematode Caenorhabditis elegans, we …
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Nuclear Receptor Controls Nematode Metabolism And Development: Insight Into Man’s Nemesis, the Conqueror Worm
… role in controlling the larval development of C. elegans. Activation of DAF-12 by its ligands called dafachronic acids (DAs) commits the nematode to development into reproductive adult, which will otherwise arrest at a diapause stage called dauer. But the molecular mechanisms remain unclear. …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Post-Transcriptional Regulation of Maternal mRNA Shapes Early C. Elegans Embryogenesis
… expression. I discovered that seven RNA binding proteins bind directly to the zif-1 3’ UTR in a combinatorial fashion thereby ensuring that zif-1 is only translated in somatic blastomeres, beginning at the four cell stage embryo. Interestingly a similar set of RNA binding proteins (nine total) …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… death via unclear mechanisms. In the nematode C. elegans, I developed a model to study cellular degeneration in response to mechanical stress caused by blunt force trauma. I identified a dual-specificity MAPK phosphatase, VHP-1, as a stress-inducible modulator of neurodegeneration. VHP-1 regulates …