Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 372 for “"Caenorhabditis elegans"”.
-
Starvation Response in Caenorhabditis elegans
… levels of autophagy act to promote survival in Caenorhabditis elegans during starvation, whereas insufficient or excessive levels of autophagy contribute to death. I find that inhibition of autophagy decreases survival of wildtype worms during starvation. Furthermore, I find that in gpb-2 …
-
mRNA localization in Caenorhabditis elegans embryogenesis
… to answer these questions, this thesis defines Caenorhabditis elegans as a model organism for exploring mRNA localization, its mechanisms, and its functions with a focus on condensate transcripts. Thus, the discoveries made have contributed to the fields of post-transcriptional gene regulation, …
-
Sensory Organ Morphogenesis in Caenorhabditis Elegans
… presented here, I use the main sensory organ of Caenorhabditis elegans, the amphid, as a model system for understanding how glia form these compartments. First, by the interpretation of electron microscopy reconstructions of the developing amphid, I was able to uncover a role for daf-6/Patched, …
-
Aversive Olfactory Imprinting in Caenorhabditis Elegans
… underpinnings of imprinting. I have used C. elegans as a model organism to study imprinting because of its compact and well characterized nervous system, an armory of available genetic tools, and a versatile behavioral repertoire. Using a ethologically relevant training regime, I found that …
-
Density-Dependent Foraging in Caenorhabditis Elegans
… both of these predictions are met by foraging Caenorhabditis elegans. In Chapter 2, I show that animals alter their foraging behavior in response to population density, that certain pheromones induce this behavioral change, and that different wild isolates vary in response to the potent …
-
Modeling neural connectivity of caenorhabditis elegans
… to apply these methods to data recorded from C. elegans neurons and estimate the connections between these. The top two performing methods on simulated data were feed-forward neural networks and ODE reverse engineering. The worst performing methods were recurrent neural networks and Bayesian …
-
Mechanisms of Olfactory Plasticity in Caenorhabditis Elegans
… and an armory of molecular and genetic tools, C. elegans is well-suited for the study of experience-dependent plasticity. Using an olfactory adaptation paradigm in which animals lose attraction to butanone after it is paired with starvation, I here describe neuronal and molecular mechanisms that …
-
An Analysis of Synaptotagmins in Caenorhabditis Elegans
… encodes a member of the synaptotagmin family in Caenorhabditis elegans. Synaptotagmins are best known as the calcium-sensing proteins for regulated synaptic vesicle exocytosis. I examined the effects of this lesion on a number of sensory neurons and motor neurons, in order to ascertain the …
-
Temporal Processing by Caenorhabditis elegans Sensory Neurons
Caenorhabditis elegans is a promising organism for trying to understand how nervous systems generate real-time behavior. Its low neuron count suggests that we may be able to observe all of the constituents of the computation of sophisticated sensorimotor behavior. However, its appropriateness as a …
-
Modulation of touch sensitivity in Caenorhabditis elegans
… this thesis, I study mechanosensation in the C. elegans touch receptor neurons (TRNs) to understand how sensory systems are modulated and adapt to the environment. I find that the touch sensitivity in the TRNs is modulated by both mechanical and non-mechanical factors. The mechanical factors are …
-
Double-stranded RNA uptake in Caenorhabditis elegans
… for acquiring pest control. In the nematode Caenorhabditis elegans, a transmembrane protein named systemic RNAi deficient-2 (sid-2) is required for dsRNA uptake from the environment through the intestine. Furthermore, the tyrosine-protein kinase sid-3 promotes import dsRNA. However, the …
-
Host-Bacteria-Virus Interactions in Caenorhabditis elegans
… and the experimental tractability of the C. elegans host enables the study of the determinants of virus transmission. Studies from mice and insects have demonstrated that bacteria influence viral infection and transmission. Here we used Caenorhabditis elegans and Orsay virus to screen a panel …
-
Developing a Caenorhabditis elegans Model for Marfan Syndrome
… objective of this study was to establish a C.elegans MFS model and use this model to determine which genes interact with a C.elegans fbn1 homolog, MUA-3 and ascertain the role of metabolic rate in the development of MFS pathology. We isolated a temperature sensitive mutant of mua-3, a fbn1 …
-
Electrophysiological and Behavioral Mechanisms of Caenorhabditis Elegans Feeding
The file named "shtondaboris.pdf" is the primary dissertation file. Supplemental videos ("*.mpg") are also available and may be viewed individually.
-
Sensory Coding and Olfactory Integration in Caenorhabditis Elegans
… to guide meaningful behavior. The nematode Caenorhabditis elegans, for example, uses volatile cues to navigate toward food from a distance. How does an animal integrate the olfactory information from its environment? Here, I ask how multiple sensory neurons drive and shape one interneuron's …
-
Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate either Rac or Rho GTPases, respectively. The RhoGEF1 domain and the Rac pathway are required for axon guidance in neuronal …
-
Stress-induced remodeling of the caenorhabditis elegans dauer
… types. During the stress-induced dauer stage of Caenorhabditis elegans, the IL2 neurons arborize to cover the anterior body wall. In contrast, the FLP neurons arborize to cover an identical receptive field in favorable conditions. How coordinated branching is established between these two …
-
Spatiotemporal control of gene expression in Caenorhabditis elegans
… of gene expression are obtained across tissues. Caenorhabditis elegans is an important model organism for studying develop- mental processes. At the beginning of my PhD, I helped characterize the dynamics of gene expression and chromatin activity across development and aging. Follow- ing this, I …
-
Genetic regulation of cell extrusion in caenorhabditis elegans
… by cell extrusion by caspase-deficient C. elegans embryos.
-
Genetic analysis of innate immunity in Caenorhabditis elegans
Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. Several conserved activators in the p38 PMK-1 pathway have been identified and are required for pathogen resistance to the bacterium Pseudomonas aeroginosa. Thus far, screens have been performed to identify …
Page 1 of 19