Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 385 for “"Caenorhabditis"”.
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Starvation Response in Caenorhabditis elegans
… levels of autophagy act to promote survival in Caenorhabditis elegans during starvation, whereas insufficient or excessive levels of autophagy contribute to death. I find that inhibition of autophagy decreases survival of wildtype worms during starvation. Furthermore, I find that in gpb-2 …
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Density-Dependent Foraging in Caenorhabditis Elegans
… both of these predictions are met by foraging Caenorhabditis elegans. In Chapter 2, I show that animals alter their foraging behavior in response to population density, that certain pheromones induce this behavioral change, and that different wild isolates vary in response to the potent …
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mRNA localization in Caenorhabditis elegans embryogenesis
… to answer these questions, this thesis defines Caenorhabditis elegans as a model organism for exploring mRNA localization, its mechanisms, and its functions with a focus on condensate transcripts. Thus, the discoveries made have contributed to the fields of post-transcriptional gene regulation, …
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Sensory Organ Morphogenesis in Caenorhabditis Elegans
… presented here, I use the main sensory organ of Caenorhabditis elegans, the amphid, as a model system for understanding how glia form these compartments. First, by the interpretation of electron microscopy reconstructions of the developing amphid, I was able to uncover a role for daf-6/Patched, …
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Aversive Olfactory Imprinting in Caenorhabditis Elegans
<p>Early memories are especially robust and enduring, among which the most evocative example is imprinting. Imprinting was first described in newly hatched geese that form a lasting attachment to the first moving object they see. As observed in many animal species, imprinting is a process in which …
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Modeling neural connectivity of caenorhabditis elegans
Little research has been done regarding the use of modeling techniques to estimate the connectivity of a nervous system by analyzing data recorded from its neurons. In this thesis, three main methods were implemented to solve this task: Bayesian inference, artificial neural networks, and ODE …
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An Analysis of Synaptotagmins in Caenorhabditis Elegans
… encodes a member of the synaptotagmin family in Caenorhabditis elegans. Synaptotagmins are best known as the calcium-sensing proteins for regulated synaptic vesicle exocytosis. I examined the effects of this lesion on a number of sensory neurons and motor neurons, in order to ascertain the …
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Mechanisms of Olfactory Plasticity in Caenorhabditis Elegans
<p>Animals live in constantly changing environments with fluctuating resource availability and hazardous threats. By gathering information from past experiences, individuals modify their behavioral response to adapt to the changing environment, a phenomenon known as "experience-dependent …
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Temporal Processing by Caenorhabditis elegans Sensory Neurons
Caenorhabditis elegans is a promising organism for trying to understand how nervous systems generate real-time behavior. Its low neuron count suggests that we may be able to observe all of the constituents of the computation of sophisticated sensorimotor behavior. However, its appropriateness as a …
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Modulation of touch sensitivity in Caenorhabditis elegans
Sensory perception adapts to diverse environment. Although studies in the last few decades have started to address the question of how sensory systems transduce signals, how these systems cross-modulated is largely unknown. In this thesis, I study mechanosensation in the C. elegans touch receptor …
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Double-stranded RNA uptake in Caenorhabditis elegans
… for acquiring pest control. In the nematode Caenorhabditis elegans, a transmembrane protein named systemic RNAi deficient-2 (sid-2) is required for dsRNA uptake from the environment through the intestine. Furthermore, the tyrosine-protein kinase sid-3 promotes import dsRNA. However, the …
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Host-Bacteria-Virus Interactions in Caenorhabditis elegans
… viral infection and transmission. Here we used Caenorhabditis elegans and Orsay virus to screen a panel of bacteria to study their impact on virus transmission rates. We identified that exposure to and ingestion of these bacteria result in divergent bacteria-specific effects on transmission …
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Identification and Characterization of Novel Caenorhabditis Nematode Viruses
<p>The model organism, Caenorhabditis elegans, has been used in basic research for the last 50 years, providing a wealth of knowledge in a range of fields spanning genetics, development, neurobiology, and computational biology just naming a few. However, only in the last ~15 years has this model …
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Developing a Caenorhabditis elegans Model for Marfan Syndrome
<p>Marfan Syndrome (MFS) is one of the most common monogenic diseases and affects approximately 1 in 5,000 individuals worldwide. The syndrome is characterized by elongated extremities, tall stature, slender frame, and cardiac, and vision abnormalities due to severe connective tissue defects. It is …
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Electrophysiological and Behavioral Mechanisms of Caenorhabditis Elegans Feeding
The file named "shtondaboris.pdf" is the primary dissertation file. Supplemental videos ("*.mpg") are also available and may be viewed individually.
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Sensory Coding and Olfactory Integration in Caenorhabditis Elegans
… to guide meaningful behavior. The nematode Caenorhabditis elegans, for example, uses volatile cues to navigate toward food from a distance. How does an animal integrate the olfactory information from its environment? Here, I ask how multiple sensory neurons drive and shape one interneuron's …
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate either Rac or Rho GTPases, respectively. The RhoGEF1 domain and the Rac pathway are required for axon guidance in neuronal …
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Stress-induced remodeling of the caenorhabditis elegans dauer
… types. During the stress-induced dauer stage of Caenorhabditis elegans, the IL2 neurons arborize to cover the anterior body wall. In contrast, the FLP neurons arborize to cover an identical receptive field in favorable conditions. How coordinated branching is established between these two …
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Spatiotemporal control of gene expression in Caenorhabditis elegans
… of gene expression are obtained across tissues. Caenorhabditis elegans is an important model organism for studying develop- mental processes. At the beginning of my PhD, I helped characterize the dynamics of gene expression and chromatin activity across development and aging. Follow- ing this, I …
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Genetic regulation of cell extrusion in caenorhabditis elegans
Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by cell-autonomous activation of the caspase-mediated apoptosis pathway, which …
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