Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 276 for “"Cadherin"”.
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Cadherin recognition and specificity
Cadherins are calcium dependent cell adhesion molecules. The interaction between cadherin molecules is important in establishing cell polarity, tissue identity and tissue boundary. This study focused on the mechanism of cadherin mediated cell-cell interaction and binding specificity. First, the …
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Engineering biomaterial surfaces with N-cadherin
N-cadherin is a key protein that is responsible for cellular adhesion to neighboring cells in mesenchymal tissues. It plays a significant role in neural development, regeneration, and pathological processes. Recently, efforts were increasingly made to better understand biological function of …
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Cadherin specificity in adhesion and mechanotransduction
Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes. Differential binding between cadherin subtypes is widely believed to mediate cell sorting during embryogenesis. However, a …
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Regulation of cadherin adhesion at intercellular junctions
… of all multicellular organisms, and among them, cadherins are the major transmembrane cell-cell adhesion proteins in all vertebrate tissues. Regulation of cadherin mediated adhesion at cell-cell junctions is crucial to our understanding of development and disease. This thesis focuses on the …
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E-cadherin mechanotransduction beyond cell-cell junctions
Cadherins and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive complexes in diseases, cardiomyopathies, atherosclerosis, cancer, stem cell …
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Nickel Reduces Calcium Dependent Dimerization In Neural Cadherin
Cadherins are the primary transmembrane component in adherens junctions, structures that link the actin cytoskeleton in adjacent cells within solid tissues including neurological synapses, epithelium and endothelium. Cell-cell adhesion by cadherins requires the binding of calcium ions to specific …
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Engineered N-cadherin substrates for stem cell differentiation
… which implies that there is an important role of cadherin-modulated cell-cell adhesion in regulating stem cell differentiation levels. As a result, the goal for this research is to develop a hydrogel platform which integrates the effects of N-cadherin and matrix stiffness to modulate cell …
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Biophysical Characterization Of A Proline Mutant Of Neural Cadherin
Cadherins are calcium dependent glycoproteins whose homophilic interactions mediate cell-cell adhesion in solid tissues. They are comprised of an extracellular region, a transmembrane region and a cytoplasmic region. The extracellular region plays a critical role in cadherin-mediated cell adhesion, …
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Expression of E-cadherin and HGF in Hypopharyngeal Cancer
… cancer which has relatively poor prognosis. E-cadherin is a large family of Calcium dependent intercelluar Adhesion Molecule(CAM) whose functions are essential for the induction and maintenance of intercellular cohesion and hepatocyte growth factor(HGF), a potent stimulator of hepatocyte …
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Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
All three of the cadherins investigated in this thesis formed strong heterophilic bonds at three ectodomain alignments. Of the three, the inner bond (strongest) corresponding to full ectodomain overlap, did not exhibit much variation in either the homophilic or the heterophilic interactions. The …
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Mechanism of E-cadherin dimerization at the plasma membrane
Embargo set by: Seth Robbins for item 118623 Lift date: 2023-09-17T04:04:53Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system
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Structural Basis of Adhesion Activation of the Cadherin-Catenin Complex
E-cadherin is a protein that regulates cell adhesion through adherens junctions. Its dysfunction has implications in development, inflammation, and cancer metastasis. Type I classical cadherins such as E-cadherin are composed of an extracellular domain of 5 extracellular cadherin repeats …
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Alternative Splicing Expands Spatiotemporal Expression Complexity of Arthropod N -Cadherin
… silico approaches to show that the arthropod N-Cadherin gene has maintained exactly the same genomic organization, a common promoter and three sets of mutually exclusive alternatively-spliced exons (MEs), for over 400 million years. Furthermore, in vivo studies demonstrated that isoforms derived …
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Reexamining actin polymerization in maintaining cadherin mediated cell-cell adhesion
… by converting weak homophilic bonds between the cadherin cell adhesion molecules into strong adhesion. However, the most popular models to explain the role of actin at the junction do not require dynamic actin networks. According to these models, actin polymerization builds contractile actomyosin …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… and serious pathological consequences. VE-cadherin—the primary adhesion molecule at cell-cell junctions in vascular endothelial cells—governs the barrier integrity of the vascular endothelium. Previous studies showed that increased tension on VE-cadherin triggers a mechanotransduction …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… essential for the development of the pancreas. N-cadherin deficient-embryos suffer from dorsal pancreas agenesis due to apoptosis of the mesenchyme surrounding the pancreatic epithelium. N-cadherin-deficient embryos expressing N-cadherin or E-cadherin ectopically in the heart rescue dorsal …
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Kinetics and regulation of the initial stages of cadherin-mediated adhesion
… and in the maintenance of tissue integrity. Cadherins are calcium-dependent adhesion proteins which mediate cell adhesion in soft tissues. Several theories have been offered to explain the mechanism of cadherin adhesion. The first proposed mechanism put forth held that cadherins mediated …
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Investigation of minimum fragment requirement for mimicking n-cadherin mediated adhesion
Cadherins are transmembrane glycoproteins that are involved in maintaining integrity of cell junctions, morphogenesis, cell sorting and many more important biological processes. In my thesis, I have focused on studying the binding affinity of a class of cadherin superfamily called N-cadherins. …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… behind this dysregulation, pinpointing E-cadherin and β-catenin as central players in myosin VI AS regulation. β-catenin's nuclear translocation induces myosin VIshort expression, while its depletion rescues myosin VIlong. Furthermore, we uncovered β-catenin's broader involvement in AS …
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The Impact of pH on the Structure and Function of Neural Cadherin
Neural (N-) cadherin is a transmembrane protein within adherens junctions that mediates cell-cell adhesion. It has 5 modular extracellular domains (EC1-EC5) that bind 3 calcium ions between each of the modules. Calcium binding is required for dimerization. N-cadherin is involved in diverse …
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