Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Caco2"”.
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Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
The passage number and origin of two populations of Caco-2 cells influence their enterocyte-like characteristics. Caco-2 cells of passage number >90 from Novartis pharmaceutical company possess higher levels of expression of alkaline phosphatase and P-glycoprotein and a greater cellular uptake of …
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NLRP2 expressziójának vizsgálata különböző immortalizált sejtvonalakon
… sejtvonalakon. A kísérletek során THP-1, K562, Caco2, A549, NB4, U937, Hela és MCF-7 sejtvonalakat használtunk, melyeket 6, valamint 24 órás GM-CSF és dexametazon kezeléseknek vetettük alá. A kezelt sejtekből RNS-t izoláltunk, majd RT-qPCR segítségével meghatároztuk az NLRP2 relatív …
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Synthesis of sulfonylthioureas as anti-diabetic drugs
… to in-vitro cyctotoxicity screening against Caco2 cells at concentration of 100 μM and were found to be non-toxic against Caco2 cells. These compounds were then subjected to in-vitro α-glucosidase inhibition study at concentrations of 10 μM, 50 μM, 100 μM and 200 μM. …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… butyrate were examined. The initial studies used Caco2-BBE monolayers as an in vitro model for the human intestine to test for the upregulation of GLUT2 mRNA abundance by butyrate and other SCFA. Next, the impact of butyrate on glucose transport by the intestine was examined using the Sprague …
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Die funktionelle Bedeutung des Coxsackie- und Adenovirus Rezeptors (CAR) im kolorektalen Karzinom
… Karzinom zu analysieren. In den Zelllinien CaCo2, Colo205, DLD1, HCT116, HT29, SW480 und T84 konnte die Expression von CAR (mRNA und Protein) nachgewiesen werden. Nach stabiler CAR-Überexpression durch Transfektion von CARcDNA in DLD1, HCT116 und SW480 wurde das Zellwachstum gehemmt und eine …
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Interplay between Cannabinoids, SOCS3, and Autophagy Process in the Intestinal Epithelium with the Use of an Established in vitro Model System.
… a dose-dependent manner in fully differentiated CaCo2 cells. ACEA and AEA induced canonical autophagy, which was cannabinoid receptor (CNR)-l mediated. In contrast, CBD-induced autophagy is partially non-canonical and not CNR1 receptor mediated. Functionally, all three cannabinoids reduce SOCS3 …
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Entwicklung eines Dual-Luciferase-Reportergen-Assays zum Nachweis der Induktion antioxidativer Enzyme durch Nahrungsbestandteile
… Im Zuge dessen wurden drei Säugetierzelllinien (CaCo2, IEC-18, V79) auf ihre Eignung zur Modellzelllinie untersucht. Aufgrund der Transfektionseffizienz wurde die Fibroblastenzelllinie V79 ausgewählt. Zur Gewährleistung eines hohen Substanzdurchsatzes des DLR-Assays wurden bei der Etablierung …
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Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis
… of GS2 to invade human epithelial cell line Caco2, and suggested that C. concisus strains of the two genomospecies may have different virulence potential. However, no studies to date have examined the genomes of C. concisus strains from different genomospecies. The comparative genome analysis …
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Leishmanicidal, anti-inflammatory and anti-obesity properties of natural products from common medicinal and edible plants.
… and IL-8) in LPS-stimulated RAW macrophages and Caco2 cells. The MC-treated animals, fed high-fat diet did not gain weight and did not develop fat liver disease compared to control animals. Also, when compared to control animals, the blood metabolic and inflammatory biomarkers from MC-treated …
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Genomic analysis in human solid tumours:Copper Homeostasis Genes in Colorectal cancer
… significantly reduced the tumor growth in a Caco2 colorectal cell line. It has been demonstrated that the copper addition increase the toxic effects of some copper binding compounds, in particular, the ionophore copper-ionophore 5-chloro-8-hydroxyquinoline (ClHQ) and the copper chelator …
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Studies on biological activities of Scottish plants.
… and normoxic conditions, using 3 cell lines CaCo2, MCF -7, and MDA 468 and it was observed that they had higher acitivty in hypoxic conditions compared to normoxic conditions, an interesting finding as often larger tumours have hypoxic states in the peripheral regions. The two tropane …
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Novel insights into the interaction between iron and curcumin and its physiological consequences
… iron overload, HydroCurc® led to a greater Caco2 cell proliferation vs native curcumin (p<0.0001) and mitigated the iron-induced permeability of Caco-2 monolayers. Additionally, HydroCurc® increased cellular ferritin to up to 160.5% vs cells treated only with iron (p<0.0001). The formulated …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… for 21 days. A transwell co-culture system of Caco2 cells and MΦ subsets was developed to mimic the cell-to-cell cross-talk between epithelial cells and immune cells. Mono- and co-culture models were pre-treated with either LPS, TNFα or IL-1β prior to stimulation by PAMPs. TNFα, IL-1β, IL-18, …
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Synthesis and application of a grafted flocculant produced from a chemical combination of a bioflocculant TKT and acrylamide (AM)
… it was treated in high concentration) while CaCO2 cells (retained 64% of cell viability after it was treated in high concentration). TKT-g-PAM6 was cation and pH dependent and optimally flocculated kaolin clay suspension at a dosage of 0.2 mg/ml with 74% of flocculating activity in the …
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Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
… was evaluated through Caco-2 monolayer and Caco2/HT29 co-culture cell lines in order to understand the intestinal barrier transport mechanism. Results: The employed Box Behnken design resulted in the formulation of particles which were <100nm in size, PDI <0.3, a negative surface charge …
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Terminalia ivorensis and human health: the impact of Terminalia ivorensis on biomarkers of cyto- and genotoxicity in human cells in vitro.
Terminalia ivorensis (TI) is a tree found in the tropical and sub-tropical zones of the world. It is used in ethnomedicine for the treatment of diuresis, body pains, malaria and wound healing. There are no data investigating the impact of TI on human liver cells and cancer. Cancer is a global …