Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Cachectic"”.
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Skeletal muscle adaptations in cachectic, tumor-bearing rats
… reversed plantaris muscle atrophy in cachectic, tumor-bearing rats (n=5). FO plantaris masses were ~24% larger than contralateral controls. However, this hypertrophic response was not as great as FO plantaris muscles from healthy, sham-operated controls (~44% larger than contralateral …
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The Influence of Quercetin, Curcumin, and Resistance Exercise On Anabolic Signaling In the Skeletal Muscle of Cachectic Mice
… exercise alone increased body weight in cancer cachectic mice. However, the combination treatment of nutraceuticals and resistance exercise was not able to increase body weight. In conclusion, supplementation with quercetin, curcumin, or resistance exercise alone may be potential therapies for …
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The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover
… underlying the suppressed anabolic signaling in cachectic muscle, gaps still remain in our understanding of muscle’s ability to respond to anabolic stimulus prior to cachexia development. The purpose of this study was to determine if cachexia progression disrupts the feeding regulation of AMPK …
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Selective Muscle Degeneration in a Drosophila Model of Cachexia; A Role for the Transcriptional Regulator cabut
… characterized by progressive muscle wasting. Cachectic muscle wasting presents as a comorbidity with pathological illnesses like cancer, chronic inflammation, and type 2 diabetes. The development of cachexia complicates treatment of these diseases and worsens clinical outcomes. Thus, it has …
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Insulin resistance in cancer cachexia and metabolic syndrome
… resistance and inflammation, control, non-cachectic and cachectic cancer patients were selected and the respective circulating levels of pro-inflammatory mediators and microRNA-21-5p, a posttranscriptional regulator of STAT3 expression, assessed and correlated. Cachectic patients …
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Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
… to cause 20% of cancer-associated deaths. Cachectic patients exhibit both metabolic abnormalities and systemic inflammation. Pyruvate Dehydrogenase Kinase 4 (PDK4) is upregulated in the skeletal muscles of many cancer cachexia models and has been shown to drive muscle wasting in some …
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The role of eicoapentaenoic acid in cancer cahexia
… isolated from the MAC16 tumour, and the urine of cachectic cancer patients, using a series of ion exchange and gel exclusion chromatography procedures. This lipid-mobilising factor (LMF) has been demonstrated to stimulate lipolysis in adipocytes dose-dependently via a signal transduction pathway …
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Sex Differences in Cancer Cachexia and a Novel Mitochondrial Target for Cancer-Induced Muscle Wasting
… 1, 2, 3, or 4-wk to assess the time course of cachectic development. We found a dichotomous effect on tumor mass between 3- and 4-wk animals where approximately half of mice between the two groups exhibited low tumor (LT) mass (<1.2 g) while the other half developed higher tumor (HT) mass (>2 …
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The biogenesis of erythropoietin during inflammation
… of experimental anaemia. These animals were very cachectic, suggesting that a blunted erythropoietin response may depend on disease activity.
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Mechanism of action of a tumour derived lipid mobilising factor
… to reproduce this up-regulation, thus another cachectic factor is responsible. 0.58nM LMF conferred significant protection against hydrogen peroxide, paraquat and bleomycin-induced oxidative stress in the non-cachexigenic MAC13 cell line. This protection was attenuated by 10μM SR59230A …
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PERM1-Mediated Metabolic Crosstalk Between the Heart and Skeletal Muscle in Pressure Overload-Induced Heart Failure
… weight, indicating sarcopenic phenotype and not cachectic phenotype. Partial loss of PERM1 in heterozygous mice accelerated systolic decline and mortality and modulated metabolomic programs linked to ketone handling, branched and medium chain fatty acid oxidation, malate-aspartate shuttling, …
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The growth of murine breast cancer cells in dystrophic mice
… tumors of BC patients and skeletal muscles of cachectic cancer patients. However, this complex is most frequently studied for its role in Duchenne muscular dystrophy (DMD), a severe, progressive muscle wasting disease. Despite the similar alterations reported in these diseases, it is unclear …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… that occurs during aging and more prominently in cachectic AIDS and cancer patients. The loss of critical muscle mass limits mobility, decreases the quality of life and is closely associated with mortality independent of other parameters. Despite the widespread manifestations of wasting …
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Muscle catabolism in cancer and its attenuation by eicosapentaenic acid
… MAC16 tumour, and from the serum and urine of cachectic cancer patients. Previous studies have shown that PIF induces protein degradation in vitro, and that this is possibly mediated through 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of the n-6 polyunsaturated fatty acid- …
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Role of the systemic inflammatory response in the clinical and biological features of incurable cancer and cachexia
… IL‐6, TNF‐α, and IL‐8 levels were greater in cachectic patients than in healthy individuals. Several symptoms of incurable cancer were associated with elevated levels of circulating cytokines i.e., depression, fatigue, and appetite loss were all linked with increased levels of IL-6. These …
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The host response to cancer and cancer-associated cachexia
… that acute depletion of neutrophils in pre-cachectic mice impairs systemic glucose homeostasis secondary to altered hepatic lipid processing. Thus, changes in neutrophil number, distribution, and metabolism play an adaptive role in host metabolic homeostasis during cancer progression. These …
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The nature of cachexia in patients with heart failure and stable coronary artery disease
… that elevated circulating cytokines in cachectic heart failure patients would be associated with muscle inflammation, injury and impaired ability to repair. The aim of this doctoral work was to characterise the nature of cachexia in patients with heart failure (HF) and stable coronary …
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Moderators of respiratory muscle function in health, exercise and disease
… body composition and respiratory function in cachectic COPD patients, study four examined the effects of short-term high dose rhGH administration on body composition and respiratory function. Male subjects self administered 0.019 mg.kg<sup>-1</sup> .day<sup>-1</sup> for six days. After this …
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The role of Protein Degradation in Cancer Cachexia in Female Tumor Bearing Mice
<p>Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional …