Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"CaV1.3"”.
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… the expression, function and localisation of CaV1.3 using in vitro PCa cell models and during hormone therapy by utilising a range of laboratory techniques. CaV1.3 was overexpressed in AR-positive PCa cells but appeared to be localised within subcellular compartments. Treatment of LNCaP cells …
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The molecular and behavioral characterization of cav1.3 over-expressing mice
<p>Age-related cognitive decline refers to the memory impairment and difficulty learning new tasks that occurs during the normal process of aging. There are many possible changes that occur at the neuronal level that could account for age-related cognitive decline. One hypothesis suggests that a …
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Modulatory effects of Cav1.3 calcium channels on dopamine homeostasis and alpha synuclein expression in a mouse model of Parkinson’s disease
… voltage-gated calcium channels of subtype 1.3 (Cav1.3) on dopamine (DA) homeostasis and aSYN expression in Cav1.3 channel knockout mice under mitochondrial dysfunction induced by the neurotoxin 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP). Following chronic MPTP treatment, tissue samples …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… in wildtype (wt) compared to those developing in CaV1.3 subunit-deficient (CaV1.3-/- deaf) mice. The latter are deaf because of absence of glutamate release from IHC and degeneration of primary afferents and thus completely lack cochlea-driven nerve activity. Ca2+-channel properties, Ca2+ …
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Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… the a1 subunit of an L-type Ca2+ channel (LTCC), CaV1.3. Initial and several subsequent mutations cause electrophysiological gain-of-function with increased activation and/or slowed inactivation of CaV1.3. Prior to the discovery of these mutations, L-type Ca2+ channels were not considered …
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Struktur und Funktion der afferenten Synapse innerer Haarzellen der Cochlea
… nm besitzt. Auch das präsynaptische Cluster von Cav1.3-L-Typ-Calciumkanälen zeigte keine relevanten tonotopen Größenunterschiede. Simulationen lieferten eine Strukturabschätzung, die am ehesten mit einem ovalären Diskus mit einem Längsdurchmesser von etwa 420 nm vereinbar ist. Als weitere …
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
… Moreover, snapin preferentially modulated CaV1.3 channel by interacting with the I-II loop region but not on the other calcium channel of CaV1 families. In addition, voltage-gated calcium channels were modulated by anti-ganglioside antibodies. The antibodies against ganglioside are found in …
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Molecular Basis of Mechanosensitivity
… and calcium selective voltage gated channels, Cav1.2 and Cav1.3, were not found to display major mechanosensitive properties. In a complimentary approach, I performed a screen of 10 different cell lines using the poking assay to identify novel molecules involved in mechanical transduction. My …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… (Plb), L-type Ca2+ channel proteins (Cav1.2 and Cav1.3), calmodulin2 (Calm2) and Ca2+/calmodulin-dependant protein kinase II delta (CaMK2d) were significantly (p<0.05) altered in DM compared to age-matched control animals. The results showed LV and kidney remodelling in the T1DM rats …