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Showing 1 to 20 of 55 for “"CaMKII"”.

  1. Autoregulatory and structural control of CaMKII substrate specificity

    Johnson, Derrick Ethan2016

    … (CaM)-dependent protein kinase II (CaMKII) is a multimeric holoenzyme composed of 8–14 subunits from four closely related isoforms (α, β, γ, δ). CaMKII plays a strategic, multifunctional role in coupling the universal second messenger calcium with diverse cellular processes including …

    iupui Repository record

  2. In vivo visualization of CaMKII activity in ocular dominance plasticity

    Kwok, Show MingMassachusetts Institute of Technology2009

    … Ca2+/calmodulin dependent protein kinase II (CaMKII) is a major component of the postsynaptic density. Activation of CaMKII is necessary and sufficient for LTP induction, is required for OD plasticity, and its expression pattern coincides with the site of rapid plasticity in the supragranular …

    mit Repository record

  3. Camkii-Mediated Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor at Serine-150 Results in Decreased Channel Activity

    Maxwell, Joshua Thomas2016

    … is Ca2+/calmodulin-dependent protein kinase II (CaMKII). CaMKII is a multifunctional Serine/Threonine protein kinase involved in many signaling pathways in various cell types including regulating cardiac gene expression. Recent results from our lab have shown that the predominant InsP3R isoform …

    loyola-thes Repository record

  4. Effects of Supplemented Zinc on Learning and Memory in Tau Mice (P310L/CaMKII) Using Contextual and Cued Fear Extinction

    Hernandez, Carlos M

    gmu

  5. The role of PLC, cPKC, L-type calcium channels and CAMKII in insulin stimulated glucose transport in skeletal muscle

    Wright, David C.2002

    There is no abstract available for this dissertation.

    ballstate-thes Repository record

  6. CaMKII at a central synapse : α-calcium/calmodium protien kinase II and synaptic plasticity at CA3 Schaffer collateral -- CA1 synapses in the mammalian hippocampus

    Hinds, Heather L., 1969-Massachusetts Institute of Technology2001

    … calcium/calmodulin protein kinase II (CaMKII) has been shown to block LTP, and a global knockout of the highly expressed a isoform of CaMKII caused an impairment in LTP and hippocampus dependent learning. We examined the role of CaMKII in CA3-CA1 LTP by selectively deleting …

    mit Repository record

  7. Induction and Maintenance of Synaptic Plasticity

    Graupner, MichaelTechnische Universität Dresden

    … calcium/calmodulin-dependent protein kinase II (CaMKII) and its regulating protein signaling cascade has been hypothesized to durably maintain the synaptic state in form of a bistable switch. Furthermore, it has been shown experimentally that CaMKII and associated proteins such as protein kinase …

    qucosa-diss

  8. Regulation of Myosin V-Cargo Interactions by Phosphorylation

    Roland, Joseph Thomas EdwardUniversity of Illinois at Urbana-Champaign2015

    … kinases, Calcium/calmodulin-dependent kinase II (CaMKII) and p21-activated kinase-1 (PAK1), are able to phosphorylate the globular tail of myosin V. Mutation analysis and mass spectrometry were used to determine the actual site of phosphorylation for each kinase. The target of CaMKII …

    uiuc Repository record

  9. Estudio del papel de CSPa/DNAJC5 en la función y mantenimiento de las sinapsis glutamatérgicas del hipocampo en ratones adultos

    Mesa Cruz, Cristina2023

    … (TMX) carentes de CSP /DNAJC5 (ratones CaMKII creERT2:Ai27D:Dnajc5flox/ ) y carentes de la proteína SNARE SNAP25 (CaMKII creERT2:Ai27D:Snap25flox/flox) específicamente en neuronas glutamatérgicas del prosencéfalo para el estudio de las sinapsis glutamatérgicas que forman las neuronas …

    sevilla Repository record

  10. The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury

    Huaiyu TanThe University of Texas Medical Branch2005

    … \r\n Calcium-calmodulin protein kinase II (CaMKII) has been shown to be responsible for enhancing ionotropic glutamate receptor mediated activity. CaMKII also has been shown to be a molecular intermediate in both long-term potentiation (LTP) and peripherally induced central sensitization. …

    utmb Repository record

  11. Metabolic Regulation of Cellular Signaling

    Darbandi, Rashid John2017

    … of Ca2+/calmodulin-dependent protein kinase II (CaMKII). We recently identified coenzyme A (CoA), derived from the breakdown of acetyl-CoA, as the key metabolic signal that mediates a novel mechanism of calmodulindependent activation of CaMKII. CoA binds directly to the calmodulin (CaM) binding …

    tenn-hsc Repository record

  12. The role of Substance P and its signaling pathways in central sensitization

    Jingyin YanThe University of Texas Medical Branch2007

    … calcium/calmodulin-dependent protein kinase II (CaMKII) and protein kinase C (PKC), to spinal cord pain mechanisms, following NK-1 activation. Spinothalamic tract (STT) cells in lumbar segments of the rat spinal cord were retrogradely labeled with fluorogold (FG). Colocalization of NK-1 receptors …

    utmb Repository record

  13. Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans

    Knight, Kaz, author, Hoerndli, Frederic, advisor, Chicco, Adam, committee member, Tsunoda, Susan, committee member, Markus, Steven, committee memberColorado State University. Libraries2026

    … transcription. Chapter 4 examines the role of CaMKII in ROS signaling using redox resistant rescues in CaMKII mutant backgrounds. Using a catalase mutant to increase ROS, we expose a difference in regulation in the soma and neurite, dependent on relevant regulatory residues and the environment. …

    colostate Repository record

  14. THE PROTECTIVE EFFECTS OF CHRONIC CAFFEINE TREATMENT ON THE COGNITIVE FUNCTION AND SYNAPTIC PLASTICITY IN ACUTE SLEEP DEPRIVATION

    Alhaider, IbrahimUniversity of Houston2010

    … protein kinase II (P-CaMKII) and brain-derived neurotrophic factor (BDNF). In addition, caffeine treatment of sleep-deprived rats increased the levels of P-CaMKII during the expression of E-LTP. The results also showed that chronic caffeine treatment prevented the …

    houston Repository record

  15. CHRONIC STRESS REVEALS COGNITIVE IMPAIRMENT IN A SUBTHRESHOLD AMYLOID-BETA MODEL OF ALZHEIMER’S DISEASE

    Tran, Trinh T. 1982-University of Houston2010

    … to stress have reduced basal levels of p-CaMKII, decreased p-CaMKII/CaMKII ratio, and increased basal levels of calcineurin. The infusion of subAβ into the cerebral ventricle of chronically stressed rats also decreased basal levels of p-CREB, total CREB and BDNF and increased basal levels …

    houston Repository record

  16. Spatiotemporal Dynamics of CaMKI During Structural Plasticity of Single Dendritic Spines

    Ramnath, Rohit2016

    … of activity. While the function and activity of CaMKII in synaptic plasticity has been extensively studied, that of CaMKI, another major class of CaMK required for LTP, still remain elusive. </p><p>Here, we develop a Förster’s Resonance Energy Transfer (FRET) based sensor to measure the …

    duke Repository record

  17. Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation

    Feng, YuqingUniversity of Cambridge2025

    … calcium/calmodulin-dependent protein kinase II (CaMKII), implicating the calcium/CaMKII pathway in regulating synaptic aSyn dynamics and potentially in modulating its physiological function via pS129. In summary, our findings uncover a dual role for oxysterols in neurodegeneration: they promote …

    cambridge Repository record

  18. The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency

    Carson, BrianDublin City University2010

    … activation of the signalling kinases AMPK and CaMKII than low intensity exercise (40% VO2peak), whereas the frequency of contraction (50 vs 80 RPM) had no effect on AMPK and CaMKII phosphorylation. PGC-1a mRNA was upregulated after exercise with a greater increase observed after high compared …

    dcu Repository record

  19. Mechanisms of Synapse Formation and Synaptic Plasticity

    Luk, Collin Chill-FoneGraduate Studies2015

    … of potentiation is calcium/calmodulin kinase II (CaMKII). Taken together, these studies demonstrate both intrinsic and extrinsic mechanisms of synapse formation and identify a novel role for CaMKII in a use-dependent form of synaptic plasticity.

    calgary Repository record

  20. CaMKIIbeta in Pain and Addiction

    Giokdjen Ilktach (19841195)2026

    … Ca2+/calmodulin dependent protein kinase II (CaMKII) represents a promising target as previous studies show the involvement of CaMKII and one of its four isoforms, CaMKIIα, in chronic pain. This study delves into understanding CaMKIIβ in pain and opioid addiction. Looking to reveal if CaMKIIβ …

    uic

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