Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 212 for “"CaCO₃"”.
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Development of in vitro Chylomicron Assay Using Caco-2 Cells
<p>Dietary fats are mainly transported by the intestine in lipoproteins: chylomicrons (CMs) and very low density lipoproteins (VLDLs). Unfortunately, studies of the intestinal absorption of dietary fat have been hampered by the lack of an adequate in vitro model system. As an <em>in vitro</em> …
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Mechanism(s) involved in the transport of Fenretinide across Caco-2 monolayers
<p>Femetinide is a synthetic retinoid with chemotherapeutic activity against various malignancies. After oral administration to animals, femetinide was found to be incompletely absorbed and excreted primarily in feces. The purpose of this study was to investigate the mechanism(s) responsible for …
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Einfluss des Flavonoids Quercetin auf die epitheliale Barrierefunktion der humanen Kolonkarzinom-Zelllinie Caco-2
Ein hoher Verzehr von Obst und Gemüse scheint das Risiko der Inzidenz verschiedener Erkrankungen zu reduzieren. Es wird vermutet, dass eine Gruppe sekundärer Pflanzeninhaltsstoffe, die Flavonoide, hierfür verantwortlich sind. Mögliche Effekte auf die intestinale Barrierefunktion dieser …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
Flavonoids are known to interact with a number of membrane transporters, influencing the rate of intestinal nutrient absorption. The transcriptional effects and consequences of such interactions remained to be fully elucidated. To address this we carried out gene expression microarray analysis on …
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Uptake and transport of orally-deliverable drugs across caco-2 cell monolayers:the effect of lipid formulations
The aim of this thesis is to investigate the physicochemical parameters which can influence drug loading within liposomes and to characterise the effect such formulations have on drug uptake and transport across in vitro epithelial barrier models. Liposomes composed of phosphatidylcholine (PC) or …
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Regulation of mTORC1 Signalling and Amino Acid Uptake by Iron Availability in Caco-2 Intestinal Epithelial Cells
Iron is an essential micronutrient in the human diet that plays a vital role in the control of cell growth and multiple other cellular processes. Iron deficiency is the most prevalent nutritional deficiency in the UK (WHO). The Scottish Government (RESAS division) has funded the current study in an …
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A comparison of durability and recruitment for reef mimics constructed from marine concrete and CaCO₃-enriched concrete
… but few studies have investigated the role of CaCO₃ as a concrete additive in increasing biodiversity, species recruitment, material strength and durability, and ion leaching. Textured reef mimics in both standard marine concrete and CaCO₃-enriched concrete were studied constructed and deployed …
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Polysaccharide controls on the kinetics and thermodynamics of CaCO₃ nucleation: Insights for biological crystallization and other biofunctions
… direct the heterogeneous nucleation of calcite (CaCO₃), an important marine biomineral. At many sites of CaCO₃ biomineralization, anionic polysaccharides are intimately associated with chitin. To establish a broader understanding of macromolecular controls on mineralization, this dissertation is …
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In vitro starch digestibility and ex-vivo glucose response studies of Vietnamese starchy foods using Caco-2 cells and 14C radioisotope
A systematic scientific investigation of starch digestibility and glucose response of the most commonly consumed Vietnamese rice varieties, rice and wheat products have not been studied yet. Starchy staples were investigated for their physicochemical properties, in vitro starch digestibility and …
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The intestinal absorption of n-3 and n-6 polyunsaturated fatty acids: proposed mechanisms from studies using human Caco-2 cells.
This thesis presents an innovative investigation of the process by which specific dietary fatty acids, the n-3 and n-6 polyunsaturated fatty acids (PUFAs), enter the intestinal absorptive cell. The intake of these particular fats and the ratio of n-6/n-3 PUFAs have been correlated with the …
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
Small proline-rich protein-2 (SPRR2) functions as a determinant of flexibility and permeability in the mature cornified envelope of the skin. SPRR2 is strongly upregulated by the commensal flora and may mediate signaling to differentiated epithelia of the small intestine and colon. Yet, SPRR2 …
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Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
Mediterranean diet is considered a model of healthy nutrition, able to prevent and/or slow down the progression of the most common degenerative diseases, such as Cardiovascular Disease (CVD) and Inflammatory Bowel Disease (IBD), characterized by a chronic inflammation state that alters structure …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
Background and aims: It has been reported that epithelial cells are involved in the process of inflammatory bowel disease (IBD) producing proinflammatory cytokines and chemokines. Glucocorticoids, being the most effective drugs for IBD patients, seem to have influence not only on the infiltrated …
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Interaction of peptides, peptidomimetics and other drug candidates with the DI/tripeptide transport system in intestinal epithelial cells, using the in vitro caco-2 cell culture system
An uptake system was developed using Caco-2 cell monolayers and the dipeptide, glycyl-[3H]L-proline, as a probe compound. Glycyl-[3H]L-proline uptake was via the di-/tripeptide transport system (DTS) and, exhibited concentration-, pH- and temperature-dependency. Dipeptides inhibited uptake of the …
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Phospholipid Transfer Protein (Pltp): Secretion, Gene Expression, and Functions in Cultured Cells
PLTP secretion was also investigated by using a human small intestine cell model, Caco-2. Properties of Caco-2 secreted-PLTP were similar to those of purified human plasma PLTP. Treatment of the cells with butyrate and propionate enhanced PLTP secretion and PLTP gene expression.
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Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
The passage number and origin of two populations of Caco-2 cells influence their enterocyte-like characteristics. Caco-2 cells of passage number >90 from Novartis pharmaceutical company possess higher levels of expression of alkaline phosphatase and P-glycoprotein and a greater cellular uptake of …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
Rotavirus (RV) is a leading cause of diarrhoea in young children. In 2016, rotavirus-related death was estimated around 128,500, with 258,173,300 episodes of diarrhoea in children below 5 years. Although extra-intestinal rotavirus infection is limited, the spread of the virus can cause seizures and …
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