Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Ca2+ signaling"”.
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Suppression of Ca2+ Signaling Enhances Melanoma Progression
Ca2+ is a ubiquitous and dynamic second messenger molecule that is induced by many factors including receptor activation, environmental factors, and voltage, leading to pleiotropic effects on cell function including changes in migration, metabolism and transcription. As such, it is not surprising …
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… resulting in sustained elevation of cytosolic Ca2+ concentration critical for T cell activation. Sustained Ca2+ signals are important for the activation of Nuclear Factor of Activated T cells (NFAT), which is a key regulator of T cell activation through its transcriptional control of genes in …
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Mechanically driven In vivo Osteocyte Ca2+ Signaling: Aging and Pharmacologic Effects
… mouse model with a genetically encoded calcium (Ca2+) indicator (GECI) targeted to osteocytes to allow measurement of osteocyte Ca2+ responses to loading in vivo and (2) novel in vivo bone loading-imaging approaches that allow real-time visualization of osteocyte responses. Using these …
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Novel methods for biological network inference: an application to circadian Ca2+ signaling network
Biological processes involve complex biochemical interactions among a large number of species like cells, RNA, proteins and metabolites. Learning these interactions is essential to interfering artificially with biological processes in order to, for example, improve crop yield, develop new …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… and agonist-mediated changes in cytosolic free Ca2+ concentration ([Ca2+]i). An increase in protein S-glutathionylation is a common response to oxidative stress; however, the role of glutathionylation in Ca2+ homeostasis and Ca2+ signaling processes is not well understood. Diamide, a …
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Plasticity of Adrenal Chromaffin Cell Function During Inflammation and Exposure to Microbe-Associated Molecular Patterns
… (GI) and systemic inflammation modulate ACC Ca2+ signaling, and that ACCs possess the ability to directly detect microbe-associated molecular patterns (MAMPs). Ca2+ signaling was assessed in single ACCs isolated from control mice and mice with GI or systemic inflammation using Ca2+ imaging …
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The Impact of Acetylcholine Receptors on Osteocytes and Bone Mechanoadaptation
… the resident tissue mechanotransducer. Calcium (Ca2+) signaling is a key second messenger in osteocyte mechanotransduction, however the details regarding Ca2+ signaling regulation in osteocytes in vivo are not well stratified. The nervous system is known to regulate bone. Osteocytes express …
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Retinal Ischemia in the In Vivo Rodent: Cellular and Vascular Characteristics
… to investigate retinal blood flow and glial Ca2+ signaling in health and disease. Retinal blood flow in the rat was examined by using an imaging technique known as laser speckle flowmetry (LSF) to generate two dimensional maps of blood flow changes. We demonstrated that the inner retinal and …
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Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset familial Alzheimer disease (AD), presenilin 1 and presenilin 2. Several studies …
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Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
… have been linked to abnormal calcium (Ca2+) signaling. Our laboratory recently discovered that presenilin holoproteins function as endoplasmic reticulum (ER) Ca2+ leak channels and that FAD mutations in presenilns affected this function. Our findings potentially provided an explanation …
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Crosstalk Between Calcium Signaling and Lipid Metabolism at Endoplasmic Reticulum-Plasma Membrane Junctions
Receptor-induced Ca2+ signaling is the key to many cellular functions, such as secretion, migration, differentiation, and proliferation. The increase in cytosolic Ca2+ signals is dependent on the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane (PM). To enable …
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Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
<p>Calcium ions (Ca2+) are essential signaling molecules and must be carefully regulated to preserve specificity in function. One indispensible Ca2+ signaling protein is the ryanodine receptor (RyR) calcium release channel. RyR1 is essential for muscle contraction, and RyR1mutations can lead to …
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Circadian rhythms of redox state and regulation of neuronal excitability in suprachiasmatic nucleus of rodents
… to entraining signals of light, by modulating Ca2+ signaling in response to excitatory neurotransmission, targeting on a ryanodine receptor–dependent intracellular Ca2+ store. Our study provides a novel pathway for the metabolic oscillator to engage in the organization with the central …
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LINOLEIC ACID UNLEASHES THE ANTI-TUMOR POTENTIAL OF CD8 T CELLS BY PROMOTING METABOLIC REPROGRAMMING
… (MAMs), which in turn promotes calcium (Ca2+) signaling, mitochondrial energetics, and CTL effector functions. As a result, LA-instructed CD8+ T cells mediate superior control towards different tumor types both in vitro and in vivo following ACT on mouse models, overcoming the hustle of a …
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Development and Testing of Pharmacological Tools to Evaluate the Role of Protease-Activated Receptor-2 in Allergic Asthma
… I report here that PAR2 antagonist C391 blocks signaling and symptoms caused by the asthma causing allergen Alternaria alternata. I show C391 effectively inhibits A. alternata-induced PAR2-MAPK and -Ca2+ signaling in vitro and attenuates asthma symptom development (e.g. airway …
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Structure-based development of novel chemical scaffolds as inhibitors of the store-operated calcium entry pathway
Calcium (Ca2+) is an intracellular messenger regulating various physiological activities. The ‘store-operated calcium entry’ (SOCE) is a significant, almost ubiquitous Ca2+ signaling pathway and is triggered when intracellular Ca2+ stores (e.g., endoplasmic reticulum, ER) are depleted, either …
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… These adaptations can be regulated by various Ca2+-dependent signaling processes. STIM1 is an important regulator of Ca2+ signaling in different cell types by sensing endoplasmic reticular Ca2+ levels and coupling to plasma membrane Orai channels. The role of STIM1 in heart is not well …
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Molecular genetic characterization of ataxic movement disorders in mouse and human
… add weight to a role for aberrant intracellular Ca2+ signaling in Purkinje cells in the pathogenesis of spinocerebellar ataxia.
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Molecular mechanisms of stress tolerance in plants
… are necessary to modulate early responses (e.g. Ca2+ signaling) to both stresses. Understanding these layers of cross-talk may lead to more sustainable methods to employ innate immunity to protect against both biotic and abiotic stress induced crop losses.
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Illuminating Organellar and Molecular Organization of the Endomembrane System
… mediate cellular activities ranging from Ca2+ signaling to lipid metabolism. I provide quantitative information on spatial organization of endoplasmic reticulum-plasma membrane junctions and show that it is in part regulated by F-actin. This gives clues about how cellular activities of …
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