Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Ca2+ sensitization"”.
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… (1) characterizing the basal expression level of Ca2+ sensitization proteins in unstimulated gastrointestinal (GI) smooth muscles from regionally and functionally distinct regions and (2) addressing a fundamental question in the smooth muscle field; does exogenously applied agonist in the myobath …
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Role of ROK and PKC in Permeabilized Rabbit Femoral Artery
… signaling; once the mechanisms of smooth muscle Ca2+ sensitization and desensitization are fully understood, then the development of advanced treatments for vascular disorders such as hypertension, cerebral and coronary vasospasm, and vascular hyporeactivity following hemorrhagic shock may be …
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Integration of signalling in smooth muscle caveolae
… the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase activity. Here I test whether protein kinase C and Rho-associated kinase-mediated Ca2+ sensitization depends on caveolae using gene disrupted (KO) mice. While …
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A role for focal adhesion kinase in the contraction of gastric fundus smooth muscle evoked by cholinergic neurotransmission
… (Chapter 2) and (2) characterizing the change in Ca2+ sensitization proteins distribution at focal adhesion sites under electric field stimulation induced cholinergic neurotransmission and FAK phosphorylation regulation (Chapter 4). In carrying out the first project, the contractile responses of …
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Haploinsufficiency of Cardiac Myosin Binding Protein-C in the Development of Hypertrophic Cardiomyopathy
… TAC and sham Het cardiomyocytes and significant Ca2+ sensitization is also observed. Finally, deficits in systolic function in vivo are evident in the Het TAC hearts compared to WT TAC.</p><p>These findings demonstrate that Het MYBPC3 truncation mutant mice have baseline dysfunction that leads to …
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ROCK2 Polymorphism in Patients with Vasospastic Angina
… of myosin light chain phosphorylation and Ca2+ sensitization. Expression of ROCK/Rho-kinase mRNA was significantly increased and up-regulated at the spastic coronary artery in a porcine model, and a specific inhibitor of ROCK/Rho-kinase inhibited coronary artery spasm in humans. We, …