Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Ca2+ sensing"”.
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Studies of calcium signalling mechanisms in human platelets
… and central to this role is cytosolic calcium (Ca2+) elevation. The two ways in which this can occur are release from intracellular Ca2+ stores and the entry of Ca2+ across the plasma membrane (PM). Changes in cytosolic Ca2+ are required to enable a variety of platelet responses. In platelets …
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Unraveling the Role of SNARE Interactions in Neurotransmitter Release
The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is tightly controlled by an intricate protein machinery. Essential components of this machinery are the synaptic vesicle protein synaptobrevin and the plasma membrane proteins syntaxin 1 and SNAP-25, which are …
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THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
… to the visinin-like (VSNL) subfamily of EF-hand Ca2+-sensing proteins. Evidence in literature alongside previous transcriptomic data from our laboratory, consistently reported a downregulation of this gene in RTT patients and mouse models. However, HPCAL4 functions remain fully undisclosed; …
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Structural and Functional Studies of SLO K+ Channels: Mechanisms of Gating by Intracellular Signaling
… molecular architecture of SLO1's Ca<sup>2+</sup>-sensing module: CTDs from the four subunits of a tetrameric SLO1 channel assemble in a so-called gating ring structure at the intracellular face of the membrane. In conjunction with other studies, these results describe how Ca<sup>2+</sup> binding …