Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Ca2+ homeostasis"”.
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SPCA and regucalcin: expression, activity and regulation in Ca2+ homeostasis
… of enzymes not involved in Ca\(^{2+}\) homeostasis, as well as have intrinsic enzymatic activity in itself as a gluconolactonase. It was of interest in the present studies to examine how SPCA can be regulated and how RGN can contribute to the regulation of Ca\(^{2+}\) homeostasis within …
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Uncovering Zn2+ and Ca2+ Homeostasis and Crosstalk in Primary Hippocampal Neurons
<p>Zn<sup>2+</sup> has been suggested to act as an intracellular signaling molecule due to its regulatory effects on numerous protein targets including enzymes, transcription factors, ion channels, neurotrophic factors, and postsynaptic scaffolding proteins. However, intracellular Zn<sup>2+</sup> …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
… acinar cell exocytosis requires precise calcium (Ca2+) signals. When cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and …
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Herp Reduces ER Calcium Content by Proteasomal Degradation of SERCA
… (ER) stress inducible protein, reduces ER Ca2+ content in neurons and prevents their apoptosis. An understanding of the mechanism by which Herp decreases ER Ca2+ content requires studies of Herp interacting proteins, which could be SERCA and the proteasome. Herp may recruit the proteasome …
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Mechanisms of monohalogenated acetic acid induced genomic DNA damage
… of GAPDH was known to disrupt cellular Ca2+ homeostasis and generate reactive oxygen species (ROS). The roles Ca2+ and ROS played in mode of genotoxic action for the monoHAAs were investigated. Each of the monoHAAs generated biomarkers of oxidative stress, measured both with …
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Investigating the role of mitochondrial Ca2+ in in vivo models of neurodegenerative diseases
… processes, including sequestering and releasing Ca2+. The dysregulation of mitochondrial Ca2+ homeostasis has recently been recognised as a key pathology of neurodegeneration, although the causes and impacts of mitochondrial Ca2+ dysregulations remain unclear. Mitochondrial Ca2+ homeostasis is …
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THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… models. Recent data suggest misregulation of Ca2+ homeostasis in a cardiomyocyte cell line after TCE exposure (Caldwell, Thorne et al. 2008). We hypothesized that misregulation of Ca2+ homeostasis alters myocyte function and leads to changes in embryonic blood flow. In turn, changes in cardiac …
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Embryonic Epithelial Development is Modulated by Extracellular Calcium
… culture medium above or below the physiological Ca2+ concentration of embryonic chick serum strongly influenced gastrointestinal development. Culture of 16- or 18-day embryonic intestine in high Ca2+ resulted in elevated activity of alkaline phosphatase, a brush border digestive enzyme, and an …
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PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
Abnormal homeostasis of intracellular Ca2+ plays a deleterious role in muscle pathologies by triggering processes that lead to dysfunction and necrotic or apoptotic cell death. One pathology where there is significant Ca2+ induced cell damage is ischemia, which initiates further damage (also …
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Inhibition of the Calcium Plateau Following In Vitro Status Epilepticus Prevents the Development of Spontaneous Recurrent Epileptiform Discharges
… It has been demonstrated in vivo that calcium (Ca2+) dynamics are severely altered during SE and that elevations in intracellular Ca2+ ([Ca2+]i) in hippocampal neurons are maintained well past the duration of the injury itself (Ca2+ plateau). Here we report that similar changes in [Ca2+]i are …
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ROS regulation of axonal mitochondrial transport
… including aerobic ATP production and calcium (Ca2+) homeostasis, but are also a major source of reactive oxygen species (ROS) production. To maintain cellular function and survival in neurons, mitochondria are transported along axons, and accumulate in regions with high demand for their …
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Investigating the effect of amyotrophic lateral sclerosis-associated mutant vesicle-associated membrane protein B on axonal transport
… acts as a sensor for cytosolic calcium levels ([Ca2]c); elevated [Ca2+]c disrupts mitochondrial transport via an effect on Miro1. To gain insight into the mechanism underlying the VAPBP56S effect on mitochondrial transport, I monitored [Ca2+]c levels in VAPBP56S expressing primary rat cortical …
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Ryanodine receptor expression in trophoblasts
… various cellular activities. Transcellular Ca2+ transport through trophoblasts is essential in fetal skeleton formation. Ryanodine receptors (RyRs) are high conductance cation channels that mediate Ca2+ release from intracellular stores to the cytoplasm. To date, the roles of RyRs in …
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Ion Transport in Chloroplasts with Role in Regulation of Photosynthesis
… ion transport across membranes and control ion homeostasis in chloroplasts. The work presented in this thesis addresses the role in regulation of photosynthesis of ion channels and transporters from the chloroplast inner envelope (Paper I), and the thylakoid membrane (Paper I to V) of …
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Contributions to the Analysis of Biochemical Reaction-Diffusion Networks Stability, Analysis, and Numerical Solutions
… IGF receptor; the core apoptosis pathway; and Ca2+ homeostasis in non-excitable cells.
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Structural And Mechanistic Elucidation Of The EF-hand In LETM1 Ca2+/H+ Antiporter Function
Mitochondrial calcium (Ca2+) is integral cellular energy production; however, excessive Ca2+ leads to cell death. Both these processes are crucial to cellular function, and thus Ca2+ homeostasis is tightly regulated. Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) is an essential …
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NESFATIN-1 AND NESFATIN-1-LIKE PEPTIDE: NUCLEOBINDIN-1/2-ENCODED INSULINOTROPIC AND ENTEROTROPIC PEPTIDES
… are a class of secreted, multi-domain Ca2+ binding proteins that interact with nucleic acids. Two nucleobindins, nucleobindin-1 (NUCB1) and nucleobindin-2 (NUCB2) have been identified so far. In 2006, nesfatin-1, an 82 amino acid peptide encoded in NUCB2 was discovered. Nesfatin-1 is an …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… and agonist-mediated changes in cytosolic free Ca2+ concentration ([Ca2+]i). An increase in protein S-glutathionylation is a common response to oxidative stress; however, the role of glutathionylation in Ca2+ homeostasis and Ca2+ signaling processes is not well understood. Diamide, a …
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Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… contraction, the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is also highly expressed in the brain and therefore is suspected to play a role in the regulation of neuronal Ca2+. Proper Ca2+ homeostasis is one of the most important factors of cognition, and dysfunctional SERCA has been …
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Reactive Oxygen Species-Induced Necrotic Cell Death
… dinucleotide (NAD), elevations in intracellular Ca2+ concentrations, loss of mitochondrial membrane potential, and subsequent necrotic cell death. Interestingly, PARP-1 hyperactivation was not accompanied by the translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus, a …
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