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Showing 1 to 20 of 877 for “"Ca2+"”.
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Ca2+ dependant synaptic modification
It has been assumed that Ca2+ influx of different duration and amplitude would generate different level of potentiation. The conventional protocols of generating LTP have been 1. tetanic stimulation of presynaptic cell, 2. theta burst stimulation of presynaptic cell, and 3. correlated stimulation …
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Signalling to intracellular Ca2+ channels
Ryanodine receptors (RyR), expressed within the ER or plasma membrane (PM), may contribute to regulated insulin secretion from pancreatic β-cells. Amplification by RyR of the Ca$^{2+}$ signals evoked by voltage-gated Ca$^{2+}$ channels may contribute to the second phase of insulin release, but the …
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Suppression of Ca2+ Signaling Enhances Melanoma Progression
Ca2+ is a ubiquitous and dynamic second messenger molecule that is induced by many factors including receptor activation, environmental factors, and voltage, leading to pleiotropic effects on cell function including changes in migration, metabolism and transcription. As such, it is not surprising …
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… resulting in sustained elevation of cytosolic Ca2+ concentration critical for T cell activation. Sustained Ca2+ signals are important for the activation of Nuclear Factor of Activated T cells (NFAT), which is a key regulator of T cell activation through its transcriptional control of genes in …
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Die Bindung von Ca2+-Ionen an Zebrafisch-GCAP4
… dann verschiedene Experimente zur Bindung von Ca2+-Ionen an dieses durchgeführt werden. Zum einen wurde die elektrophoretische Mobilität von zGCAP4 untersucht, die wie bisher auch unter Ca2+-Einfluss höher, unter Mg2+-Einfluss aber wesentlich niedriger war. Zum anderen wurde ein …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
Ca2+ is a universal and versatile intracellular messenger, regulating a vast array of biological processes due to variations in the frequency, amplitude, spatial and temporal dynamics of Ca2+ signals. Increases in cytosolic free Ca2+ concentration ([Ca2+]c) are due to influx from either an infinite …
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Functional properties and Ca2+-dependent feedback modulation of voltage-gated Ca2+ channels in glutamatergic nerve terminals of the mammalian auditory brainstem
… Arbeit wurden funktionelle Eigenschaften sowie Ca2+-abhängige feedback -Modulation der präsynaptischen spannungsabhängigen Ca2+-Kanäle (VGCCs) untersucht. Zu diesem Zweck wurden patch-clamp-Messungen an zwei Typen von großen glutamatergen Nervendigungen im auditorischen Stammhirn der Maus den …
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Analysis of intracellular Ca2+ oscillations in a neuroendocrine cell
Contains fulltext : 147080.pdf (Publisher’s version ) (Open Access)
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Regulation of Ca2+-Activated K+ Channel: Changes with Development
<p>In ovine middle cerebral arteries, it has been shown that the [Ca<sup>2+</sup>]<sub>i</sub> change in response to iberiotoxin, a selective BK channel blocker, is significantly different between adult and fetal VSMCs. Our study of basilar VSMCs in whole-cell preparations showed that the total …
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Glutamatrezeptoren und Ca2+-Homöostase in Hirnstamm-Motoneuronen der Maus
… Bedeutung nimmt dabei ein Glutamat-vermitteltes Ca2+-Signal ein, da das Ca2+-Ion als zellulärer Botenstoff eine Reihe enzymatischer Reaktionen hervorrufen kann. Eine langfristig erhöhte freie zytoplasmatische Ca2+-Konzentration begünstigt letztlich die Aktivierung von Proteasen, Lipasen und …
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Endoplasmic Reticulum Morphoregulation Modulates Ca2+- Driven Brain Cell Functions
… of the ER is to store large amounts of calcium (Ca2+ ) and sequester the ion on low-affinity/high-capacity protein carriers. This enables the ER to rapidly release Ca2+ in response to specific signals, either globally or locally. This led me to investigate how the tubular ER structure supports …
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High-resolution optical analyses of IP3-evoked Ca2+ signals
Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they bind IP3 produced after activation of cell-surface receptors. Vertebrate …
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Messung der intrazellulären Ca2+-Konzentration in Gefäßendothelzellen unter rheologischer Beanspruchung
… kultivierten Endothelzellen nach Applikation von Ca2+-erhöhenden Agonisten, Calciumionophoren sowie während rheologischer Beanspruchung in Echtzeit zu dokumentieren. Die Eignung des verwendeten rheologischen Systems für Scherstressexperimente konnte durch die Beobachtung der für Endothelzellen …
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Regulation des Na+/Ca2+-Austauschers in kultivierten Podozyten der Maus
Der Na+/Ca2+-Austauscher ist an der zellulären Ca2+-Homöostase beteiligt. Er arbeitet in zweierlei Modi: dem Forward Mode und dem Reverse Mode. Letzterer dient dem Ca2+-Export nach einem transienten Anstieg der intrazellulären Ca2+-Konzentration, sei es im Rahmen physiologischer Vorgänge …
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The role of Ca2+ in photosystem 2 of anacystis nidulans
… nidulans and its subsequent reactivation with Ca2+ , it was found that 4 Ca2 were required for the complete stimulation of PS2. Through cooperative binding, these 4 Ca 2 join to their site, the affinity of which changes towards Ca2 according to the absence or presence of Mg2t These observed …
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SPCA and regucalcin: expression, activity and regulation in Ca2+ homeostasis
… activity can be inhibited without altering hSERCA2b activity by using bis-phenol and 2-APB; (3) TFP and TBBPA affect both hSPCA1d and hSERCA2b activities to the same degrees, while cADPR and NAADP have no effect on hSPCA1d (and possibly hSERCA2b in the case of cADPR) activity; (4) RGN mRNA …
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Endozytose des Ca2+-sensitiven hIK1-Kanals in migrierenden MDCK-F-Zellen
… Interaktion notwendig. Bei selektiver Blockade Ca2+-sensitiver K+-Kanäle (IK1) durch das Skorpiongift Charybdotoxin wird die Migrationsfähigkeit von Zellen erheblich gestört. Da dies ein möglicher thera-peutischer Ansatzpunkt zur Malignitätsreduzierung von Tumoren durch Hemmung der …
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Fluorescence Off-On Sensors for F-, K+, Fe3+, and Ca2+ Ions
… significant ions, including F-, K+, Fe3+, and Ca2+. All of these sensors demonstrate fluorescence "turn-on" response upon interacting with their respective ions, which makes them much more appealing than those based on fluorescence quenching mechanisms. In Chapter II, a novel highly selective …
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