Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"CYTOTOXIC NECROTIZING FACTOR"”.
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Distinguishing delivery and catalytic activity differences among G-protein deamidating protein toxins of the cytotoxic necrotizing factor (CNF) and Pasteurella multocida toxin (PMT) family through comparative analyses
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Comparative analysis of cytotoxic necrotizing factor (CNF) toxins: Compatibility of cargo with delivery vehicle and identification of amino acid residues that modulate pH-dependent cytosolic cargo delivery
… This thesis explores the suitability of the cytotoxic necrotizing factor (CNF) family as a model system for the development of Bacterial Toxin-Inspired Drug Delivery (BTIDD) platforms. The CNF family is notable among AB toxins in that there are nine full-length homologs and many CNF-like …
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Investigation of the intracellular trafficking pathways of the dermonecrotic toxin family
… (PMT) from Pasteurella multocida (P. multocida), cytotoxic necrotizing factors 1, 2, and 3 (CNF1, 2 and 3) from Escherichia coli (E. coli), the cytotoxic necrotizing factor Y (CNFY) from Yersinia pseudotuberculosis (Y. pseudotuberculosis), and the dermonecrotic toxin (DNT) from Bordetella species …
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Studies of Three Human Intestinal Opportunistic Pathogens
… and evaluation of the role of several virulence factors and environmental modulators in the pathogenesis of this strain. We used a newly developed lux gene reporter to evaluate gene expression in Bacteroides. We observed that there are barriers in both transcription and translation initiation …
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Studies on the mode of action of dermonecrotic toxins: Effects on adipogenic signaling pathways and delivery of c-terminal cargo into the cytosol
… toxin from Bordetella spp. (DNT), the cytotoxic necrotizing factors from Escherichia coli (CNF1, CNF2 and CNF3) and Yersinia pseudotuberculosis (CNFY), and the mitogenic toxin from Pasteurella multocida (PMT). These relatively large (100-160 kDa), single polypeptide protein toxins share …