Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CYP51"”.
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Capture and Characterization of Dioxygen Reactive Intermediates in CYP51 Catalysis
… the C-C bond cleaving enzymes and in particular CYP51 from Mycobacterium tuberculosis are though to be capable of utilizing multiple reactive oxygen intermediates. During the process of C-C bond cleavage, CYP51 catalyzes two classical hydroxylation reactions. The final reaction culminates in an …
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Comparative structural analysis of cytochrome P450 family CYP51 in the genus Cryptococcus
Cytochrome P450 monooxygenase CYP51 (sterol 14α-demethylase) is a well-known target of the azole drug fluconazole for treating cryptococcosis, a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance …
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Targeting CYP5122A1 and CYP51 for the Inhibition of Ergosterol Biosynthesis in Trypanosomatids
… for its potential as a therapeutic target. CYP5122A1, another CYP enzyme found in both Leishmania and Trypanosoma species, has been demonstrated to be essential for L. donovani survival and plays an important but unknown role in leishmanial ergosterol biosynthesis.In this study, an …
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Toxicological evaluation of azole fungicides in agriculture and food chemistry
… auf der Hemmung der Lanosterol-14α-Demethylase (CYP51), die die Demethylierung von Lanosterol zum „Follicular Fluid Meiosis Activating Steroid (FF-MAS)“ katalysiert. Für Pilze ist das später resultierende Ergosterol ein essentieller Bestandteil der Zellmembran. Exponierten Pilzen fehlt Ergosterol …
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Characterizing resistance of Erysiphe necator to fungicides belonging to the quinone outside inhibitors and demethylation inhibitors
… in E. necator included the Y136F mutation in CYP51 and cyp51 over-expression. The first mechanism was present in almost all isolates with substantial levels of resistance, and cyp51 expression level was correlated with resistance level. Three cyp51 genotypes were detected. Wildtype isolates …
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Characterization of Maize Cytochrome P450s
… encoded by other maize P450 clones (CYP71C1, CYP51, CYP73A7, CYP73A6, CYP92A1, CYP95A1, and the ESTs 6c06b11 and 7c02c12) were also characterized with regard to their induction response to naphthalic anhydride and triasulfuron treatment. In addition, maize seedlings were also subjected to the …
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Adaptive metabolic gene clusters as toolkits for chemical innovation: Investigation of the origin of the avenacin gene cluster for synthesis of defense compounds in oats
… the ancestral triterpene biosynthetic OSC/CYP51 gene pair found in the �-WGD event. Finally, the evolutionary model of the avenacin biosynthesis and the potential applications of the knowledge of gene clustering in systematic and synthetic biology are descibed in Chapter 7. *[N.B.: …
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FUSARIUM MUSAE AND FUSARIUM VERTICILLIOIDES CROSS-KINGDOM PATHOGENS: GENOMICS AND DIAGNOSTIC INNOVATION
… time. Structural and functional analyses of CYP51 paralogs revealed candidate genetic determinants linked to azole resistance, providing novel insights into antifungal adaptation mechanisms and highlighting evolutionary pathways relevant to both agricultural and clinical environments within …
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… (14α-lanosterol demethylase, also known as CYP51) are all primary mechanisms of azole resistance that arise in azole-resistant clinical isolates. These changes are known to be mediated through gain-of-function mutations in the genes of a fungal-specific transcription factor family known as …