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Showing 1 to 3 of 3 for “"CYP33"”.
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The Role of Cyp33 in MLL Mediated Gene Repression
… with MLL leukemias.</p><p>Cyclophilin33 (CYP33) has previously been shown to be a negative modulator of MLL gene transactivation activity (Fair, K 2001, Anderson, M 2002). It has been well established that for CYP33 to exert its repressive effects on MLL several events must occur. CYP33 …
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Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3
… "writer" with an embedded "reader" for H3K4Me3. Cyp33 is another known ligand of MLL PHD3. Over expression of Cyp33 results in transcriptional repression of MLL target genes.</p> <p>The aim of this study is to determine the biological function of MLL PHD3 binding to H3K4Me3 or Cyp33. Cyp33 …
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Role of Non-Coding RNA NC4 in MLL and CYP33 Mediated Regulation of HOXC8
… of transcription. A nuclear cyclophilin called CYP33 interacts with the third Plant Homeo Domain (PHD) of MLL via its N terminal RNA Recognition Motif (RRM) such that its overexpression switches the function of transcriptional activator protein MLL towards transcriptional repressor. This …